Results 11 to 20 of about 86,323 (286)

RNA Regulation by Poly(ADP-Ribose) Polymerases [PDF]

Molecular Cell, 2015
Posttranscriptional regulation of RNA facilitates the fine-tuning of gene expression. It occurs through multiple pathways that include the nuclear processing of mRNA and its precursors, mRNA silencing, regulation of mRNA decay, and regulation of translation. Poly(ADP-ribose) polymerases (PARPs), enzymes that modify target proteins with ADP-ribose, play
Bock, Florian J., Todorova, Tanya T., Chang, Paul   +2 more
openaire   +2 more sources

Chromosomal instability syndromes are sensitive to poly ADP-ribose polymerase inhibitors

Haematologica, 2008
Poly ADP-ribose polymerase inhibitors have been shown to target cells with homologous recombination DNA repair defects. We report that poly ADP-ribose polymerase inhibitors induces apoptosis in cells deficient in other key DNA repair components ...
Terry J. Gaymes, Sydney Shall, Farzin Farzaneh, Ghulam J. Mufti   +3 more
doaj   +1 more source

Neurological and histological consequences induced by in vivo cerebral oxidative stress: evidence for beneficial effects of SRT1720, a sirtuin 1 activator, and sirtuin 1-mediated neuroprotective effects of poly(ADP-ribose) polymerase inhibition.

PLoS ONE, 2014
Poly(ADP-ribose)polymerase and sirtuin 1 are both NAD(+)-dependent enzymes. In vitro oxidative stress activates poly(ADP-ribose)polymerase, decreases NAD(+) level, sirtuin 1 activity and finally leads to cell death.
Cindy Gueguen, Bruno Palmier, Michel Plotkine, Catherine Marchand-Leroux, Valérie C Besson   +4 more
doaj   +1 more source

Automodified Poly(ADP-Ribose) Polymerase Analysisto Monitor DNA Damagein Peripheral Lymphocytes of Floriculturists Occupationally Exposed to Pesticides

Cells, 2019
Increased DNA damage and the propension to cancer development, depend on the modulation of the mechanisms to control and maintain genomic integrity. Poly(ADP-Ribose)Polymerase activation and automodification are early responses to genotoxic stress.
Serena Imperato, Carmela Mistretta, Maria Marone, Ilaria Migliaccio, Ilaria Pulcinelli, Maria Rosaria Faraone Mennella   +5 more
doaj   +1 more source

PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment

BMC Cancer, 2022
Chemokines are highly expressed in tumor microenvironment and play a critical role in all aspects of tumorigenesis, including the recruitment of tumor-promoting immune cells, activation of cancer-associated fibroblasts, angiogenesis, metastasis, and ...
Sarah Johnson, Yaroslava Karpova, Danping Guo, Atreyi Ghatak, Dmitriy A. Markov, Alexei V. Tulin   +5 more
doaj   +1 more source

Chromatin composition is changed by poly(ADP-ribosyl)ation during chromatin immunoprecipitation. [PDF]

PLoS ONE, 2012
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which is followed by isolation of specific protein-DNA complexes and subsequent PCR testing, to analyze DNA-protein interactions.
Sascha Beneke, Kirstin Meyer, Anja Holtz, Katharina Hüttner, Alexander Bürkle   +4 more
doaj   +1 more source

Structural modeling of NAD+ binding modes to PARP-1

Вавиловский журнал генетики и селекции, 2017
The nuclear protein poly (ADP-ribose) polymerase-1 (PARP-1) plays an important role in the signaling and repair of DNA. PARP-1 catalyses covalent binding of poly (ADP-ribose) polymers with itself as well as with other acceptor proteins using NAD+ as a ...
N. V. Ivanisenko, D. A. Zhechev, V. A. Ivanisenko   +2 more
doaj   +1 more source

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.

Cancer Research, 2006
Deficiency in either of the breast cancer susceptibility proteins BRCA1 or BRCA2 induces profound cellular sensitivity to the inhibition of poly(ADP-ribose) polymerase (PARP) activity.
N. Mccabe, N. Turner, C. Lord, Katarzyna Kluzek, A. Białkowska, S. Swift, Sabrina Giavara, M. O’Connor, A. Tutt, M. Zdzienicka, G. Smith, A. Ashworth   +11 more
semanticscholar   +1 more source

Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization

Cell Reports, 2019
Summary: Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization of bone and the vasculature has devastating effects on patient health, yet an integrated understanding of the chemical and cell ...
Karin H. Müller, Robert Hayward, Rakesh Rajan, Meredith Whitehead, Andrew M. Cobb, Sadia Ahmad, Mengxi Sun, Ieva Goldberga, Rui Li, Uliana Bashtanova, Anna M. Puszkarska, David G. Reid, Roger A. Brooks, Jeremy N. Skepper, Jayanta Bordoloi, Wing Ying Chow, Hartmut Oschkinat, Alex Groombridge, Oren A. Scherman, James A. Harrison, Anja Verhulst, Patrick C. D’Haese, Ellen Neven, Lisa-Maria Needham, Steven F. Lee, Catherine M. Shanahan, Melinda J. Duer   +26 more
doaj   +1 more source

Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome

JACC: Basic to Translational Science, 2018
Summary: Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress.
Sven Y. Surikow, BHlthSc (Hons), Thanh H. Nguyen, MD, MMedSci, PhD, Irene Stafford, BSc, Matthew Chapman, BSc, MClinSci, DMU, CEPIA, Sujith Chacko, MBBS, Kuljit Singh, MBBS, PhD, Giovanni Licari, BSc, PhD, Betty Raman, MBBS, Darren J. Kelly, PhD, Yuan Zhang, MBBS, PhD, Mark T. Waddingham, BSc (Hons), PhD, Doan T. Ngo, BPharm, PhD, Alexander P. Bate, Su Jen Chua, MBBS, Michael P. Frenneaux, MD, John D. Horowitz, MBBS, BMedSci(Hons), PhD   +15 more
doaj   +1 more source