Results 241 to 250 of about 86,323 (286)

Interaction of poly(ADP-ribose)polymerase with DNA polymerase ?

Molecular and Cellular Biochemistry, 1994
Homogeneously purified poly(ADP-ribose) polymerase (PARP) specifically stimulated the activity of immunoaffinity-purified calf or human DNA polymerase alpha by about 6 to 60-fold. Apparently, poly(ADP-ribosyl)ation of DNA polymerase alpha was not necessary for the stimulation.
S, Yoshida, C M, Simbulan
openaire   +2 more sources

Activity Assays for Poly-ADP Ribose Polymerase

2004
Poly(ADP-ribose) polymerase (PARP-1) is a nuclear enzyme that has traditionally been thought to require discontinuous or "damaged" DNA (dcDNA) as a coenzyme, a preconception that has limited research mainly to its role in cell pathology, i.e., DNA repair and apoptosis.
Eva, Kirsten, Ernest, Kun, Jerome, Mendeleyev, Charles P, Ordahl   +3 more
openaire   +2 more sources

Detection of poly(ADP-ribose) polymerase and its reaction product poly(ADP-ribose) by immunocytochemistry

The Histochemical Journal, 1996
Poly(ADP-ribose) polymerase catalyses the formation of ADP-ribose polymers covalently attached to various nuclear proteins, using NAD+ as substrate. The activity of this enzyme is strongly stimulated upon binding to DNA single or double strand breaks. Poly(ADP-ribosyl)ation is an immediate cellular response to DNA damage and is thought to be involved ...
J H, Küpper, L, van Gool, M, Müller, A, Bürkle   +3 more
openaire   +2 more sources

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Nature, 2005
H. Bryant, N. Schultz, H. Thomas, Kayan M. Parker, Dan Flower, Elena Lopez, S. Kyle, M. Meuth, N. Curtin, T. Helleday   +9 more
semanticscholar   +1 more source

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

Nature, 1994
Y. Lazebnik, S. Kaufmann, S. Desnoyers, G. Poirier, W. Earnshaw   +4 more
semanticscholar   +1 more source

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

Science, 2002
Seong-Woon Yu, Hongmin Wang, M. F. Poitras, C. Coombs, W. Bowers, H. Federoff, G. Poirier, T. Dawson, V. Dawson   +8 more
semanticscholar   +1 more source

The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

Pharmacological Reviews, 2002
L. Virág, C. Szabó
semanticscholar   +1 more source

Poly(ADP-ribose) polymerase and aging

2001
Publisher Summary Poly(ADP-ribose) polymerase (PARP) is a major nuclear protein associated with chromatin that contains zinc fingers and binds to either double- or single-strand DNA breaks. Upon binding to DNA, PARP is activated and forms covalent homopolymers of poly(ADP-ribose) (PAR) attached to a number of nuclear proteins, including itself and ...
Dean S. Rosenthal, Cynthia M. Simbulan-Rosenthal, Wen Fang Liu, Mark E. Smulson   +3 more
openaire   +1 more source

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.

Science, 1998
Susan Smith, Izabela Giriat, A. Schmitt, T. Lange   +3 more
semanticscholar   +1 more source

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

The Lancet, 2010
M. Audeh, J. Carmichael, R. Penson, M. Friedlander, B. Powell, K. Bell-McGuinn, C. Scott, J. Weitzel, A. Oaknin, N. Loman, K. Lu, R. Schmutzler, U. Matulonis, M. Wickens, A. Tutt   +14 more
semanticscholar   +1 more source