Results 31 to 40 of about 86,323 (286)

Poly(ADP-ribosyl)ation of p53 In Vitro and In Vivo Modulates Binding to its DNA Consensus Sequence

Neoplasia: An International Journal for Oncology Research, 2001
The tumor-suppresser p53 undergoes extensive poly(ADP-ribosyl)ation early during apoptosis in human osteosarcoma cells, and degradation of poly(ADP-ribose) (PAR) attached to p53 coincides with poly(ADP-ribose)polymerase-1, (PARP-1) cleavage, and ...
Cynthia M. Simbulan-Rosenthal, Dean S. Rosenthal, RuiBai Luo, Raed Samara, Mira Jung, Anatoly Dritschilo, Alexander Spoonde, Mark E. Smulson   +7 more
doaj   +1 more source

HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones

Nature Communications, 2021
Once DNA breaks occur, poly(ADP-ribose) polymerase 1 (PARP1) ADP-ribosylates itself and other DNA repair factors to initiate the repair process. Here, the authors resolve the crystal structures of mouse and human HPF1, and human HPF1/PARP1 complex ...
Fa-Hui Sun, Peng Zhao, Nan Zhang, Lu-Lu Kong, Catherine C. L. Wong, Cai-Hong Yun   +5 more
doaj   +1 more source

Pyridazine Based Compounds with PARP-1 Inhibitory Activity

Archives of Pharmaceutical Sciences Ain Shams University, 2023
Pyridazine-containing compounds have been identified as potent PARP1 inhibitors. The PARP is a family of enzymes essential for many cellular processes such as DNA repair, genomic stability, and apoptosis, also known as poly(ADP-ribose) synthetases and ...
Norhan A. Abdelrahman, Mai Y. Jaballah, Ahmed A. Al-Karmalawy , Khaled A. M. Abouzid   +3 more
doaj   +1 more source

Poly(ADP-ribose)polymerase inhibition decreases angiogenesis [PDF]

Biochemical and Biophysical Research Communications, 2006
Inhibitors of poly(ADP-ribose)polymerase (PARP), a nuclear enzyme involved in regulating cell death and cellular responses to DNA repair, show considerable promise in the treatment of cancer both in monotherapy as well as in combination with chemotherapeutic agents and radiation.
Rajesh, M., Mukhopadhyay, P., Godlewski, G., Batkai, S., Hasko, G., Liaudet, L., Pacher, P.   +6 more
openaire   +3 more sources

PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment

Communications Biology, 2023
The poly (ADP-ribose) polymerase (PARP1) interacts with the telomere factor TRF1 and loss of PARP1 results in telomere fragility and impairment of helicases -TRF1 complex assembly.
C. Maresca, A. Dello Stritto, C. D’Angelo, E. Petti, A. Rizzo, E. Vertecchi, F. Berardinelli, L. Bonanni, A. Sgura, A. Antoccia, G. Graziani, A. Biroccio, E. Salvati   +12 more
doaj   +1 more source

Kynurenine–PARP-1 Link Mediated by MicroRNA 210 May Be Dysregulated in Pulmonary Hypertension

Anatolian Journal of Cardiology, 2022
Background: Dysregulation of microRNAs is associated with pulmonary hypertension. The present study aimed to determine the alterations in microRNA and microRNA expressions and their role in signaling pathways and investigate the relationship with serum ...
Alperen Emre Akgun, Yalın Tolga Yaylalı, Mücahit Seçme, Yavuz Dodurga, Hande Şenol   +4 more
doaj   +1 more source

PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase*

Journal of Biological Chemistry, 1999
Poly(ADP-ribosylation) is a post-translational modification of nuclear proteins in response to DNA damage that activates the base excision repair machinery. Poly(ADP-ribose) polymerase which we will now call PARP-1, has been the only known enzyme of this
J. Amé, V. Rolli, V. Schreiber, C. Niedergang, F. Apiou, P. Decker, S. Muller, T. Höger, J. M. Murcia, G. de Murcia   +9 more
semanticscholar   +1 more source

Metabolic roles of poly(ADP-ribose) polymerases [PDF]

Seminars in Cell & Developmental Biology, 2017
Poly(ADP-ribosyl)ation (PARylation) is an evolutionarily conserved reaction that had been associated with numerous cellular processes such as DNA repair, protein turnover, inflammatory regulation, aging or metabolic regulation. The metabolic regulatory tasks of poly(ADP-ribose) polymerases (PARPs) are complex, it is based on the regulation of metabolic
Vida, András, Márton, Judit, Mikó, Edit, Bay, Péter   +3 more
openaire   +3 more sources

Involvement of Poly(ADP-ribose) Polymerase-1 and XRCC1/DNA Ligase III in an Alternative Route for DNA Double-strand Breaks Rejoining*

Journal of Biological Chemistry, 2004
The efficient repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genomic integrity. In mammalian cells, the nonhomologous end-joining process that represents the predominant repair pathway relies on the DNA-dependent protein ...
M. Audebert, B. Salles, P. Calsou
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source