Results 81 to 90 of about 106,568 (297)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

The Role of PARPs in Inflammation—And Metabolic—Related Diseases: Molecular Mechanisms and Beyond

Cells, 2019
Poly(ADP-ribosyl)ation (PARylation) is an essential post-translational modification catalyzed by poly(ADP-ribose) polymerase (PARP) enzymes. Poly(ADP-ribose) polymerase 1 (PARP1) is a well-characterized member of the PARP family.
Yueshuang Ke, Chenxin Wang, Jiaqi Zhang, Xiyue Zhong, Ruoxi Wang, Xianlu Zeng, Xueqing Ba   +6 more
doaj   +1 more source

TIPARP is involved in the regulation of intraocular pressure

Communications Biology, 2022
TIPARP, an inducible poly-ADP-ribose polymerase, is identified as a novel regulator of intraocular pressure through modulation of extracellular matrix and cell cytoskeleton proteins in trabecular meshwork cells.
Youjia Zhang, Maomao Song, Yingwen Bi, Yuan Lei, Xinghuai Sun, Yuhong Chen   +5 more
doaj   +1 more source

Inhibition of Poly ADP-Ribose Glycohydrolase Sensitizes Ovarian Cancer Cells to Poly ADP-Ribose Polymerase Inhibitors and Platinum Agents

Frontiers in Oncology, 2021
BackgroundPoly ADP-ribose glycohydrolase (PARG) is responsible for the catabolism of PARP-synthesized PAR to free ADP-ribose. Inhibition of PARG leads to DNA repair interruption and consequently induces cell death.
Emad Matanes, Emad Matanes, Vanessa M. López-Ozuna, David Octeau, Tahira Baloch, Florentin Racovitan, Amandeep Kaur Dhillon, Roy Kessous, Roy Kessous, Oded Raban, Oded Raban, Liron Kogan, Liron Kogan, Shannon Salvador, Shannon Salvador, Susie Lau, Susie Lau, Walter H. Gotlieb, Walter H. Gotlieb, Amber Yasmeen   +19 more
doaj   +1 more source

Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes. [PDF]

, 2019
Poly(ADP-ribose) polymerase 1 (PARP-1) is a multidomain multifunctional nuclear enzyme involved in the regulation of the chromatin structure and transcription.
Ampofo, Michelle, Boyle, Cody, Currie, Michelle, Datz, Haily, Harbin, Jonathan, Ji, Yingbiao, Johnson, Sarah J., Lodhi, Niraj, MacLeod, Brett, Patel, Shri, Pechenkina, Kate, Thomas, MD, Colin, Tulin, Alexei V., Wu, Chao   +13 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy

Frontiers in Pharmacology, 2020
Poly(ADP-ribose)polymerase-1 (PARP1) is a DNA repair enzyme highly expressed in the nuclei of mammalian cells, with a structure and function that have attracted interest since its discovery.
Stephen A. Jannetti, Stephen A. Jannetti, Stephen A. Jannetti, Brian M. Zeglis, Brian M. Zeglis, Brian M. Zeglis, Brian M. Zeglis, Michael R. Zalutsky, Thomas Reiner, Thomas Reiner, Thomas Reiner   +10 more
doaj   +1 more source

Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib [PDF]

, 2018
Upon DNA binding the poly(ADP-ribose) polymerase family of enzymes (PARPs) add multiple ADP-ribose subunits to themselves and other acceptor proteins.
Albert, Ali, Ame, Amit Nathubhai, Audebert, Barkauskaite, Beck, Benhur, Benjamin, Blenn, Boehler, Boulton, Braun, Bridges, Brochu, Bryant, Bryant, Bryant, Calabrese, Chalmers, Chang, Chang, Chang, Chow, Cortes, deMurcia, Ding, Dominic I. James, Donawho, Drean, Dungey, Dungey, Efimova, El-Khamisy, Emma Grant, Erdelyi, Fabbro, Fathers, Feng, Feng, Feng, Fisher, Godon, Gravells, Ha, Helen E. Bryant, Huang, Illuzzi, James, James Neale, Kate M. Smith, Khan, Kim, Le Page, Lee, Lomax, Martin, Medvedeva, Min, Miwa, Morrison, Mueller, Nakadate, Nathubhai, Noel, Okano, Oplustil O'Connor, Ozaki, Polly Gravells, Ray Chaudhuri, Rothkamm, Rulten, Rulten, Saleh-Gohari, Schlicker, Schreiber, Senra, Shall, Shelton, Shirai, Shirai, Slade, Strom, Sugimura, Tripathi, Trucco, Venere, Wang, Wang, Wang, Wieler, Yang, Yeh, Yoshikawa, Zhu   +94 more
core   +2 more sources

Proteomic Investigation of Phosphorylation Sites in Poly(ADP-ribose) Polymerase-1 and Poly(ADP-ribose) Glycohydrolase [PDF]

Journal of Proteome Research, 2008
Phosphorylation is a very common post-translational modification event known to modulate a wide range of biological responses. Beyond the regulation of protein activity, the interrelation of phosphorylation with other post-translational mechanisms is responsible for the control of diverse signaling pathways.
Gagné, Jean-Philippe, Moreel, Xavier, Gagné, Pierre, Labelle, Yves, Droit, Arnaud, Chevalier-Paré, Mélissa, Bourassa, Sylvie, Mcdonald, Darin, Hendzel, Michael, Prigent, Claude, Poirier, Guy   +10 more
openaire   +3 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source