Results 11 to 20 of about 20,290 (148)

Immunotherapeutic effects of intratumoral nanoplexed poly I:C [PDF]

Journal for ImmunoTherapy of Cancer, 2019
Poly I:C is a powerful immune adjuvant as a result of its agonist activities on TLR-3, MDA5 and RIG-I. BO-112 is a nanoplexed formulation of Poly I:C complexed with polyethylenimine that causes tumor cell apoptosis showing immunogenic cell death features and which upon intratumoral release results in more prominent tumor infiltration by T lymphocytes ...
M. Angela Aznar, Lourdes Planelles, Mercedes Perez-Olivares, Carmen Molina, Saray Garasa, Iñaki Etxeberría, Guiomar Perez, Inmaculada Rodriguez, Elixabet Bolaños, Pedro Lopez-Casas, Maria E. Rodriguez-Ruiz, Jose L. Perez-Gracia, Ivan Marquez-Rodas, Alvaro Teijeira, Marisol Quintero, Ignacio Melero   +15 more
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Immunostimulatory activity of polysaccharide–poly(I:C) nanoparticles [PDF]

Biomaterials, 2011
Immunostimulatory properties of mushroom derived polysaccharides (PS) as stand-alone agents were tested. Next, PS were nanocomplexed with polyI:C (pIC) to yield stable nanoparticles around 200 nm in size evidenced by atomic force microscopy and dynamic light scattering analyses.
Tincer G., Yerlikaya, S., Yagci F.C., Kahraman, T., Atanur O.M., Erbatur O., Gursel I.   +6 more
openaire   +7 more sources

Exploiting poly(I:C) to induce cancer cell apoptosis [PDF]

Cancer Biology & Therapy, 2017
TLR3 belong to the Toll-like receptors family, it is mainly expressed on immune cells where it senses pathogen-associated molecular patterns and initiates innate immune response. TLR3 agonist poly(I:C) was developed to mimic pathogens infection and boost immune system activation to promote anti-cancer therapy. Accordingly, TLR agonists were included in
Francesca Bianchi, Samantha Pretto, Elda Tagliabue, Andrea Balsari, Lucia Sfondrini   +4 more
openaire   +3 more sources

Activation of the NLRP3 inflammasome by intracellular poly I:C [PDF]

FEBS Letters, 2010
Several RNA viruses can be detected by the inflammasome, which promotes IL‐1β and IL‐18 secretion, but the underlying mechanisms of detection remain unclear. Cytosolic dsRNA is a replication intermediate of many RNA viruses. We show here that transfection of the dsRNA analogue poly I:C activates the NLRP3 inflammasome via a pathway requiring endosomal ...
Rajan, Jayant V., Warren, Sarah E., Miao, Edward A., Aderem, Alan   +3 more
openaire   +2 more sources

Are physiological oscillations physiological?

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley   +1 more source

LPS vs. Poly I:C Model

American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 2021
A prominent health issue nowadays is the COVID-19 pandemic, which poses acute risks to human health. However, the long-term health consequences are largely unknown and cannot be neglected. An especially vulnerable period for infection is pregnancy, when infections could have long-term health effect on the child.
Bao, Mian, Hofsink, Naomi, Plösch, Torsten   +2 more
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ORMDL3 regulates poly I:C induced inflammatory responses in airway epithelial cells [PDF]

BMC Pulmonary Medicine, 2021
Abstract Background Oroscomucoid 3 (ORMDL3) has been linked to susceptibility of childhood asthma and respiratory viral infection. Polyinosinic-polycytidylic acid (poly I:C) is a synthetic analog of viral double-stranded RNA, a toll-like receptor 3 (TLR3) ligand and mimic of viral infection.
Laura, G, Liu, Y, Fernandes, K, Willis-Owen, SAG, Ito, K, Cookson, WO, Moffatt, MF, Zhang, Y   +7 more
openaire   +5 more sources

Antigenicity of Double-Stranded Ribonucleic Acids Including Poly I:C

Experimental Biology and Medicine, 1972
SummaryRabbits repeatedly injected intravenously with poly I:C developed antibodies reactive with poly I:C. However, oral or nasal administration of poly I:C to rabbits failed to stimulate detectable circulating antibodies. Intravenous injection of ICR mice, guinea pigs, and grivet monkeys also failed to stimulate a detectable circulating antibody ...
A K, Field, A A, Tytell, G P, Lampson, M R, Hilleman   +3 more
openaire   +2 more sources

Induction of Interferon in Human Subjects by Poly I:C

Experimental Biology and Medicine, 1971
SummaryPoly I:C (rIn:rCn), a synthetic double-stranded polynucleotide previously demonstrated to be a potent inducer of interferon and host resistance to viral infection in cell culture and in animals, has been successfully used to induce interferon in human beings.
A K, Field, C W, Young, I H, Krakoff, A A, Tytell, G P, Lampson, M M, Nemes, M R, Hilleman   +6 more
openaire   +2 more sources

Short-term effects of Poly(I:C) on gut permeability

Pharmacological Research, 2015
The intestinal barrier function depends on an adequate response to pathogens by the epithelium. Toll-like receptor 3 (TLR-3) recognizes double-stranded RNA, a virus-associated molecular pattern. Activation of TLR-3 with Poly(I:C), a synthetic agonist, modulates tissue repair and permeability in other epithelia; however, the effects of local luminal TLR-
Valentina, Moyano-Porcile, Loreto, Olavarría-Ramírez, Camila, González-Arancibia, Javier A, Bravo, Marcela, Julio-Pieper   +4 more
openaire   +2 more sources