Results 41 to 50 of about 21,689 (140)

Pathological Role of Interleukin-17 in Poly I:C-Induced Hepatitis

PLoS ONE, 2013
Immune-mediated responses were the main causes of liver damage during viral hepatitis, and recently viral RNA mimetic Poly I:C was used to induce a NK cell-dominated acute hepatitis. Interleukin-17A (IL-17A), the cytokine tightly associated with various autoimmune diseases, was known to play protective or pathological roles in LPS and ConA-induced ...
Jianqin He, Guanjing Lang, Shiping Ding, Lanjuan Li   +3 more
openaire   +4 more sources

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang, Siwen Wu, Yusi Wang, Die Hu, Li Yang   +4 more
wiley   +1 more source

Myo1g Mediates NKR‐P1C Expression in Primary Mouse NK Cells and Participates in Cytotoxicity

Immunology, Volume 179, Issue 3, Page 516-524, November 2026.
In this study we analysed the participation of Myosin 1g in the development and functions of murine natural killer (NK) cells; we found that Myosin 1g is expressed in murine‐activated primary NK cells from the spleen. Additionally, in the absence of Myosin 1g, correlates with a reduced expression of NKR‐P1C but not of CD49b or NKp46.
Héctor Romero‐Ramírez, Vania Aminta Zuleica López‐Esparza, Mariana Flores‐Castelán, Leopoldo Santos‐Argumedo   +3 more
wiley   +1 more source

Therapy of Herpetic Keratitis with a Combination of Poly I:C and Idoxuridine

Ophthalmic Research, 2009
Poly I:C-IDU treatment was given to 26 eyes with superficial, and 20 eyes with stromal herpetic keratitis. In superficial keratitis the results were not superior to those of conventional IDU treatment. The favourable results observed in stromal keratitis were attributed to penetration of poly I:C into the corneal stroma, which also can explain the ...
J.A. Oosterhuis, S.H. Sie, W.A. Nolen, J. Versteeg, I.G. Jeltes   +4 more
openaire   +1 more source

Skin‐Protective Effects of Marinophyll, a Carotenoid From Marine Erythrobacter sp. SDW2

Skin Research and Technology, Volume 32, Issue 11, November 2026.
ABSTRACT Background Previous studies have highlighted that marine organisms, such as microalgae and marine bacteria, exhibit significantly higher and more sustainable biosynthetic yields of unique carotenoids compared to terrestrial sources. These advantages in production efficiency have sparked significant interest in developing materials derived from
Hyeyoun Kim, Seoyeon Kyung, Kyung Eun Lee, Youn‐Hwa Nho, Jeoungjin Ryu, Minsun Park, Yong Jun Choi, Seunghyun Kang   +7 more
wiley   +1 more source

Effect of Poli I:C in murine model of autoimmune thyroiditis [PDF]

, 2015
ABSTRACT Hashimoto’s thyroiditis is one of the most common autoimmune diseases in humans and, similar to other autoimmune diseases, is multifactorial in nature. Moreover, the expression of TLRs has been implicated in the pathogenesis of autoimmune and inflammatory diseases, such as diabetes and insulinitis.
Vera Sepulveda, Carolina Loreto, Barria Maldonado, MIguel   +1 more
openaire   +1 more source

Immunomodulatory role of paliperidone in the poly(I:C) model of schizophrenia

European Psychiatry, 2016
IntroductionAlterations on the innate inflammatory response may underlie the pathophysiology of psychiatric diseases, but the mechanisms implicated remain elusive. Current antipsychotics modulate pro/anti-inflammatory pathways, but the specific mechanisms involved remain elusive.
K. MacDowell, E. Munarriz-Cuezva, D. Martín-Hernández, A. Sayd, B. García-Bueno, J. Meana   +5 more
openaire   +1 more source

poly I:C

Citation: 'poly I:C' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13588 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source