Results 51 to 60 of about 22,066 (186)

Rutaceae Zanthoxylum–Derived 7‐Demethylsuberosin Alleviates the Rheumatoid Arthritis Through Inhibiting the Maturation of Dendritic Cells via Targeting MAPK14 Functional Food‐Based 7‐Demethylsuberosin

Food Frontiers, Volume 7, Issue 2, March 2026.
This study revealed that 7‐demethylsuberosin exhibits immunosuppressive effects both in vivo and in vitro. Furthermore, it inhibits the phosphorylation of MAPK14 by targeting it, thereby modulating dendritic cell (DC) maturation and function and reducing inflammation across various in vivo models.
Peng Han, Bo Wang, Luyang Han, Yanbo Zhu, Jiawei Dong, Yuekang Xu, Xiaoying Liu, Jinyao Li   +7 more
wiley   +1 more source

Repeated Episodes of GPP Induced by Respiratory Infections Are Mediated by Loss‐of‐Function IFIH1

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
ABSTRACT Background Generalized pustular psoriasis (GPP) is a severe and recurrent autoinflammatory disease that can be induced by a variety of factors. At present, its etiology and pathogenesis have not yet been fully elucidated. Upper respiratory tract infections are the main predisposing factor in children with GPP, and the MDA5 protein encoded by ...
Yaqin Liu, Yanan Sun, Juan Yang, Hongmei Li, Weihui Zhou, Shasha Meng   +5 more
wiley   +1 more source

poly I:C

Citation: 'poly I:C' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13588 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Drug Delivery Systems for Resiquimod to Control Myeloid‐Derived Suppressor Cells in Cancer Immunotherapy

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Myeloid‐derived suppressor cells (MDSCs) are key contributors to cancer immunotherapy failure and major targets in new therapeutic strategies. We highlight therapeutic approaches to counteract their immunosuppressive functions and discuss recent efforts to optimize drug delivery for controlling MDSCs, focusing on resiquimod as a representative drug ...
Yanying He, Yoon Yeo
wiley   +1 more source

Development of hyaluronic acid-based nanogel platform for improved stability and polyvalent ligand display of poly(I:C) as an effective immunostimulatory adjuvant in cancer immunotherapy [PDF]

, 2020
Nararat Kotcharat
openalex   +1 more source

Early Development of Ocadusertib, a Selective Receptor‐Interacting Serine/Threonine‐Protein Kinase 1 Inhibitor

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Receptor‐interacting serine/threonine‐protein kinase 1 (RIPK1) inhibitors are being investigated for chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. Ocadusertib is a potent and selective allosteric inhibitor of RIPK1 and is currently being studied in clinical trials.
Simon J. Shaw, Vanessa C. Taylor, Jonathan T. Sims, Stephen Ho, Chrystelle Lamagna, Lucy Yan, Nicholas C. Reising, Andrew Chow, Eric P. Hanson, Andrew C. Vendel, Daniel J. Dairaghi, Esteban S. Masuda   +11 more
wiley   +1 more source

Dataset related to article "Poly(I:C) stimulation is superior than Imiquimod to induce the antitumoral functional profile of tumor-conditioned macrophages."

, 2020
Akihiro Maeda, Elisabeth Digifico, Andon FT, Alberto Mantovani, Paola Allavena   +4 more
openalex   +1 more source

Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections [PDF]

, 2021
Xun Gao, Paul K.S. Chan, Grace Lui, David S.C. Hui, Ida Miu‐Ting Chu, Xiaoyu Sun, Miranda Sin‐Man Tsang, Ben Chung-Lap Chan, Christopher Wai-Kei Lam, Chun Kwok Wong   +9 more
openalex   +1 more source

Orally administered Lactobacillus rhamnosus modulates the respiratory immune response triggered by the viral pathogen-associated molecular pattern poly(I:C) [PDF]

, 2012
Julio Villena, Eriko Chiba, Yohsuke Tomosada, Susana Salva, Gabriela Marranzino, Haruki Kitazawa, Susana Alvarez   +6 more
openalex   +1 more source

Investigation of P2X7R involvement in maternal poly(i:C) exposure evoked autistic features in mice [PDF]

, 2015
Gergely Horváth, Lilla Otrokocsi, Ágnes Kittel, Mária Baranyi, Beáta Sperlágh   +4 more
openalex   +1 more source