Results 61 to 70 of about 20,290 (148)

Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Bufalin is one main component of the dried venom from Bufo gargarizans Cantor, which has anti‐tumor, cardiotonic, anti‐inflammatory and other physiological activities. However, in recent years, researchers have mainly paid attention to its anti‐tumor effect and neglected its anti‐inflammatory effect.
Xixi Liu, Chencheng Li, Jing Yang, Weiguang Zhang, Zhongxiao Hu, Xiaoli Zhang, Reaila Jianati, Fang Tian, Xingbin Dai, Zuqiong Xu, Biqing Chen, Xuejun Zhu   +11 more
wiley   +1 more source

First‐in‐Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP1617, a Cathepsin‐S Inhibitor, in Healthy Adult Subjects

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT ASP1617 is a novel, highly selective inhibitor of cathepsin‐S, an important protease for antigen peptide loading onto major histocompatibility complex class II molecules. Preclinically, ASP1617 prevented progression of lupus‐like glomerulonephritis in an NZB/W F1 mouse model of systemic lupus erythematosus.
Tomoki Kojima, Wei Chen, Ronald Smulders, Stephen Stanhope, Donna Kowalski, Nakyo Heo, Selina Moy, Amanda Goldston, David Han, Tong Zhu   +9 more
wiley   +1 more source

Stimulation von humanen gamma delta T-Lymphozyten durch Poly-Inosin-: Poly-Cytidyl-Säure (Poly (I:C)) [PDF]

, 2006
Human gamma delta T cells are a subset of T lymphocytes, belonging to lymphatic effector cells of innate immunity beside NKT cells and NK cells. After stimulation they contribute in analogy of NK cells to rapid unspecific immune responses. This work investigated for the first time the effect of a double-stranded RNA (mimicked by poly (I:C)) to human ...
openaire  

Prenatal Poly I:C exposure affects tryptophan-kynurenine metabolism associated with intestinal microbiome in female juvenile rats. [PDF]

Front Immunol
Yang L, Chen H, Zeng M, Lu Y, Xu C, Cao Z, Zhong F, Yang X, Shen A, Su Y, Deng C, Cao H.   +11 more
europepmc   +1 more source

Interaction of Selected Anthracycline and Tetracycline Chemotherapeutics with Poly(I:C) Molecules. [PDF]

ACS Omega
Skaličková M, Abramenko N, Charnavets T, Vellieux F, Leischner Fialová J, Kučnirová K, Kejík Z, Masařík M, Martásek P, Pacak K, Pacák T, Jakubek M.   +11 more
europepmc   +1 more source

A co-culture system to study the effects of Poly I:C-activated microglia on the differentiation of murine primary neural stem cells. [PDF]

In Vitro Cell Dev Biol Anim
Manitz MP, Violou K, Hedstück M, Bösing K, Kottmann M, Freund N, Juckel G.   +6 more
europepmc   +1 more source

Targeting Trichloroethylene-Induced Renal Endothelial Cell Injuries: A Role of Poly I:C in Amplification of HMGB1 Acetylation. [PDF]

J Toxicol
Wang F, Hong Y, Gao J, Cheng R, Chen M, Zang D, Zhang J, Zhu Q.   +7 more
europepmc   +1 more source

Correction to: Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I:C) for enhanced tumoral photodynamic-immunotherapy. [PDF]

Natl Sci Rev
Dai J, Wu M, Wang Q, Ding S, Dong X, Xue L, Zhu Q, Zhou J, Xia F, Wang S, Hong Y.   +10 more
europepmc   +1 more source

Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors. [PDF]

Front Immunol, 2023
Anfray C, Varela CF, Ummarino A, Maeda A, Sironi M, Gandoy S, Brea J, Loza MI, León S, Calvo A, Correa J, Fernandez-Megia E, Alonso MJ, Allavena P, Crecente-Campo J, Andón FT.   +15 more
europepmc   +1 more source

The selective ERβ agonist AC 186 reduces polyinosinic:polycytidylic acid (poly I:C)-induced inflammatory responses in BEAS-2B lung epithelial cells. [PDF]

Front Pharmacol
Olajide OA, Ogiogio HA.
europepmc   +1 more source