Results 121 to 130 of about 3,561,143 (397)

Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy. [PDF]

Natl Sci Rev, 2021
Dai J, Wu M, Wang Q, Ding S, Dong X, Xue L, Zhu Q, Zhou J, Xia F, Wang S, Hong Y.   +10 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Synthesis and Application of Poly(N-isopropylacrylamide-co-methacrylic Acid) Hydrogels as Sorbent Materials for Wastewater Treatment

Separations
N-isopropylacrylamide and methacrylic acid were copolymerized by a free radical polymerized mechanism. The obtained hydrogel poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels, poly(NIPAM-co-MAA), were utilized as sorbent material for removal Cr ...
Aleksandar Zdravković, Vesna Nikolić, Snežana Ilić-Stojanović, Sanja Stojanović, Ana Dinić, Maja Urošević, Ivana Gajić, Ljubiša Nikolić   +7 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Both-Sided TOPCon Solar Cells – Towards a Lean Process Flow for Silicon Bottom Solar Cells

SiliconPV Conference Proceedings
Silicon solar cells with both-side full-area passivating hole and electron contacts are viable candidates for application as bottom cells in tandem architectures.
Johannes Seif, Jana-Isabelle Polzin, Mathias Bories, Martin Hermle, Martin Bivour   +4 more
doaj   +1 more source

Molecular Evaluation of the Therapeutic Potential of DNA-Based Vaccines Against Experimentally Induced Lung Cancer [PDF]

Journal of Bioscience and Applied Research
Lung cancer, or lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in lung tissue. In Egypt, it has high morbidity and mortality rates.
S. Hassab El-Nabi, Abdel Aziz Zidan, Nourhan El. Ghayesh, Karolin Abdel Aziz, EL Hassan Mokhamer   +4 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

catena-Poly[[[(diethylenetriamine-κ³N,N′,N′′)copper(II)]-μ-cyanido-κ²C:N] perchlorate] [PDF]

, 2012
Peter W. R. Corfield, Sylvia C. Yang
openalex   +1 more source