Results 71 to 80 of about 279,067 (313)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Elution profile of S-100 on poly (U)-cellulose column.
, 2012 Fractions 1–20 were eluted with buffer A. Fractions 21–30 eluted with buffer B. Absorbance at 280 nm for the fractions eluted with buffer A shows the release of non-specific proteins bound to the poly (U) column.
Usha kumari Garapati (172274) +1 more
core +1 more source
Distinct roles of non-canonical poly(A) polymerases in RNA metabolism [PDF]
, 2009 Trf4p and Trf5p are non-canonical poly(A) polymerases and are part of the heteromeric protein complexes TRAMP4 and TRAMP5 that promote the degradation of aberrant and short-lived RNA substrates by interacting with the nuclear exosome. To assess the level
Schenk, L. +27 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2013 The rheological behavior of a poly(styrene)-poly(L-lactide) (PS-PLLA) block copolymer was investigated in the viscoelastic linear and nonlinear regime.
Malek, A. +5 more
core +1 more source
Inhibiting the Thermal Gelation of Copolymer Stabilized Nonaqueous Dispersions and the Synthesis of Full Color PMMA Particles [PDF]
, 2016 Polymeric particle dispersions have numerous potential applications; currently one of the most relevant is their use as inks in electrophoretic displays.
Simon J. Holder (1866523) +7 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Mikrokapsle poly(methylmethakrylát – kopolymer) / kyseliny n-hexadekanové pro tepelný komfort textilií [PDF]
ACC Journal, 2014 Tepelný komfort získaný pomocí mikrokapsulovaných materiálů se změnou fází (MPCMs) u inovačních textilních výrobků je široce zkoumán pro svou vysokou přidanou hodnotou, a procesy spojené s aplikací mikrokapslí na textilie se rapidně zrychlují ve snaze ...
Ruhan Altun Anayurt +4 more
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source