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Alternative Polyadenylation in Human Diseases
Endocrinology and Metabolism, 2017 Varying length of messenger RNA (mRNA) 3'-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing. It is prevalent through all eukaryotes and has emerged as a key mechanism for controlling gene expression.
Jae-Woong Chang +2 more
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Mechanisms and Consequences of Alternative Polyadenylation [PDF]
Molecular Cell, 2011 Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control gene expression. Like alternative splicing, usage of alternative poly(A) sites allows a single gene to encode multiple mRNA transcripts. In some cases, this changes the mRNA coding potential; in other cases, the code remains unchanged but the 3' UTR length is ...
James L. Manley +2 more
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mBio, 2019 Positive-sense RNA viruses in the Tombusviridae family have genomes lacking a 5′ cap structure and prototypical 3′ polyadenylation sequence. Instead, these viruses utilize an extensive network of intramolecular RNA-RNA interactions to direct viral ...
Jesse D. Pyle +2 more
doaj +1 more source
Analysis of circadian pattern reveals tissue-specific alternative transcription in leptin signaling pathway [PDF]
, 2007 *Background* It has been previously reported that most mammalian genes display a circadian oscillation in their baseline expression. Consequently, the phase and amplitude of each component of a signal transduction cascade has downstream ...
A Savitzky +17 more
core +3 more sources
Advanced Science, EarlyView.Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou +15 more
wiley +1 more source
Comprehensive Characterization of Alternative Polyadenylation in Human Cancer.
Journal of the National Cancer Institute, 2018 Background Alternative polyadenylation (APA) is emerging as a major post-transcriptional mechanism for gene regulation, and dysregulation of APA contributes to several human diseases.
Yu Xiang +19 more
semanticscholar +1 more source
Analysis Polyadenylation Signal Usage in Sus scrofa
Animals, 2022 RNA polyadenylation is an important step in the messenger RNA (mRNA) maturation process, and the first step is recognizing the polyadenylation signal (PAS).
Yuting Zhang +3 more
doaj +1 more source
EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways
Advanced Science, EarlyView.EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen +12 more
wiley +1 more source
Cytoplasmic Polyadenylation in Development and Beyond [PDF]
Microbiology and Molecular Biology Reviews, 1999 SUMMARY Maternal mRNA translation is regulated in large part by cytoplasmic polyadenylation. This process, which occurs in both vertebrates and invertebrates, is essential for meiosis and body patterning. In spite of the evolutionary conservation of cytoplasmic polyadenylation, many of the cis elements and trans-acting factors ...
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Scientific Reports, 2021 Transposable elements cause alternative splicing (AS) in different ways, contributing to transcript diversification. Alternative polyadenylation (APA), one of the AS events, is related to the generation of mRNA isoforms in 70% of human genes.
Hyeon-Mu Cho +7 more
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