Results 91 to 100 of about 65,820 (278)
Brain Pathology, EarlyView.Default mode network (DMN) consists, in part, of the frontal (FC), precuneus (PreC), and posterior cingulate cortex (PCC), which plays a critical role in episodic memory and retrieval of autobiographical memories, displays spatiotemporal differences in the onset of amyloid and hypometabolism that reflects tau neurodegeneration and loss of connectivity ...
Sylvia E. Perez +8 more
wiley +1 more source
Characterization of mRNA polyadenylation in the apicomplexa
PLOS ONE, 2018 Messenger RNA polyadenylation is a universal aspect of gene expression in eukaryotes. In well-established model organisms, this process is mediated by a conserved complex of 15-20 subunits. To better understand this process in apicomplexans, a group of unicellular parasites that causes serious disease in humans and livestock, a computational and high ...
Ashley T. Stevens +2 more
openaire +5 more sources
A Study of Methylated Polyadenylic Acid [PDF]
European Journal of Biochemistry, 1971 Copolymers with different contents of adenine and N1‐methyl adenine residues have been studied, polyadenylic acid being methylated by dimethylsulfate. Thermal stability, circular dichroism and light scattering measurements are in favor of a two‐strand structure at neutral pH.
Claude Thrierr, Marc Leng
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Diversity of U1 Small Nuclear RNAs and Diagnostic Methods for Their Mutations
Cancer Science, EarlyView.Complex interindividual U1 snRNA diversity was unveiled. Mutations in such complex loci were precisely detected with a pangenome graph reference, which enhances the possibility of the human pangenome reference in cancer genomics. ABSTRACT U1 small nuclear RNA (snRNA) mutations are recurrent non‐coding alterations found in various malignancies, yet ...
Takuma Nakashima +15 more
wiley +1 more source
Tissue‐specific mechanisms of alternative polyadenylation: Testis, brain, and beyond (2018 update)
Wiley Interdisciplinary Reviews - RNA, 2019 Alternative polyadenylation (APA) is how genes choose different sites for 3′ end formation for mRNAs during transcription. APA often occurs in a tissue‐ or developmental stage‐specific manner that can significantly affect gene activity by changing the ...
C. MacDonald
semanticscholar +1 more source
Preferential superficial cortical layer activation during seizure propagation
Epilepsia, Volume 66, Issue 3, Page 929-941, March 2025.Abstract Objective Focal cortical seizures travel long distances from the onset zone, but the long‐distance propagation pathways are uncertain. In vitro and in vivo imaging techniques have investigated the local spread of seizures but did not elucidate long‐distance spread. Furthermore, classical studies in slices suggested seizure spread locally along
Anastasia Brodovskaya +4 more
wiley +1 more source
APAatlas: decoding alternative polyadenylation across human tissues
Nucleic Acids Res., 2019 Alternative polyadenylation (APA) is an RNA-processing mechanism on the 3′ terminus that generates distinct isoforms of mRNAs and/or other RNA polymerase II transcripts with different 3′UTR lengths.
Wei Hong +10 more
semanticscholar +1 more source
Past, present, and future strategies for detecting and quantifying circular RNA variants
The FEBS Journal, EarlyView.Originally considered artifact of RNA splicing, over 3 million circular RNAs have been found in humans alone through a combination of ultrasensitive detection methods and bespoke bioinformatics tools. This review covers past, present, and future strategies for detecting and quantifying circular RNAs and how they are illuminating novel circular RNA ...
He Lin, Vanessa M. Conn, Simon J. Conn
wiley +1 more source
Editorial: Alternative Polyadenylation in Development and Disease
Frontiers in Genetics, 2022 Athma A. Pai, Yang I. Li, Paolo Provero
doaj +1 more source
The TP53 tumor suppressor gene: From molecular biology to clinical investigations
Journal of Internal Medicine, EarlyView.Abstract Extensively studied over the past four decades, the TP53 gene has emerged as a pivotal watchman in cellular defense and a key factor in cancer biology. TP53 is the most frequently mutated gene in human malignancies, 50% of which carry alterations to it.
Panagiotis Baliakas, Thierry Soussi
wiley +1 more source