Results 101 to 110 of about 65,820 (278)
Cytoplasmic polyadenylation by TENT5A is required for proper bone formation
Cell Reports, 2021 Summary: Osteoblasts orchestrate bone formation through the secretion of type I collagen and other constituents of the matrix on which hydroxyapatite crystals mineralize.
Olga Gewartowska +16 more
doaj
A compendium of conserved cleavage and polyadenylation events in mammalian genes
Genome Research, 2018 Cleavage and polyadenylation is essential for 3' end processing of almost all eukaryotic mRNAs. Recent studies have shown widespread alternative cleavage and polyadenylation (APA) events leading to mRNA isoforms with different 3' UTRs and/or coding ...
Ruijia Wang +3 more
semanticscholar +1 more source
Unravelling the dynamics of seed‐stored mRNAs during seed priming
New Phytologist, EarlyView.Summary Seed priming is a pre‐sowing treatment that enables more efficient and uniform seed germination; however, it negatively affects seed longevity. In this work, the mRNA dynamics underlying a hydropriming treatment have been investigated. Polysome profiling was performed on seeds during different stages of hydropriming.
Patricija Gran +7 more
wiley +1 more source
BIO-PROTOCOL, 2012 Polyadenylation is a post-transcriptional modification of RNA occurring in prokaryotes, eukaryotes and organelles. However, the function and extent of bacterial polyadenylation are in marked contrast to those of eukaryotic poly(A) tails. In fact, the long poly(A) tails of eukaryotic mRNAs play an important role in their exportation to the cytoplasm and
openaire +3 more sources
Exploring the untapped potential of single‐cell and spatial omics in plant biology
New Phytologist, EarlyView.Summary Advances in single‐cell and spatial omics technologies have revolutionised biology by revealing the diverse molecular states of individual cells and their spatial organization within tissues. The field of plant biology has widely adopted single‐cell transcriptome and chromatin accessibility profiling and spatial transcriptomics, which extend ...
Tatsuya Nobori
wiley +1 more source
New Phytologist, EarlyView.Summary Alternative splicing is essential for plants, enabling a single gene to produce multiple transcript variants to boost functional diversity and fine‐tune responses to environmental and developmental cues. Arabidopsis thaliana At‐RS31, a plant‐specific splicing factor in the Serine/Arginine‐rich (SR) protein family, responds to light and the ...
Tino Köster +18 more
wiley +1 more source
Scientific Reports, 2017 Pre-mRNA alternative splicing and alternative polyadenylation have been implicated to play important roles during eukaryotic gene expression. However, much remains unknown regarding the regulatory mechanisms and the interactions of these two processes in
Qingshun Q. Li +3 more
doaj +1 more source
Viruses, 2019 Human bocavirus 1 (HBoV1) infects well-differentiated (polarized) human airway epithelium (HAE) cultured at an air-liquid interface (ALI). In the present study, we applied next-generation RNA sequencing to investigate the genome-wide transcription ...
Wei Zou +5 more
doaj +1 more source
“Misuse” of RNA‐seq data in microbiome studies: A cautionary tale of poly(A)
mLife, EarlyView.
John Maringa Githaka
wiley +1 more source
Alternative Splicing Regulation in Metabolic Disorders
Obesity Reviews, EarlyView.ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
wiley +1 more source