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The isolation of polyadenylate with unreacted cellulose
Biochemical and Biophysical Research Communications, 1972Abstract Cellulose, unesterified with polydeoxythymidylate, polyuridylate or acetate selectively binds polyadenylate (poly [A]) and poly [A]- containing RNAs in high salt solution or in low salt solution at pH values of 5.5 or less. It does not bind heteropolymeric RNA but does have some affinity for DNA, particularly in its single-stranded form ...
P.A. Kitos, G. Saxon, Harold Amos
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In Vivo Analysis of Polyadenylation in Prokaryotes [PDF]
, 2014 Polyadenylation at the 3' ends of mRNAs, tRNAs, rRNAs, and sRNAs plays important roles in RNA metabolism in both prokaryotes and eukaryotes. However, the nature of poly(A) tails in prokaryotes is distinct compared to their eukaryotic counterparts. Specifically, depending on the organism, eukaryotic poly(A) tails average between 50 and >200 nt and can ...
Sidney R. Kushner, Bijoy K. Mohanty
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Assaying the Polyadenylation State of mRNAs
Methods, 1999The poly(A) tail present at the 3' end of most eukaryotic mRNAs can play a critical role in message translation and stability. Therefore, identifying alterations in poly(A) tail length can yield important insights into an mRNA's function and subsequent physiological impact.
William G. Richards +2 more
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Alternative polyadenylation by sequential activation of distal and proximal PolyA sites
Nature Structural & Molecular Biology, 2022Peng Tang +12 more
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Cations and the binding of polyadenylate to cellulose
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1974Abstract At neutral pH polyadenylate (poly(A)) binds to unmodified cellulose in high salt solution and is released in low salt solution. The salt effect is due principally to the cation, not to the ionic strength of the solution. Monovalent cations are not equally supportive of binding.
T. Fuller +3 more
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Bacteriophage T7 mRNA is polyadenylated
Molecular Microbiology, 1998To determine whether the RNA of bacterial viruses is polyadenylated like bacterial mRNAs, pulse‐labelled as well as the steady‐state population of bacteriophage T7‐specific transcripts were examined for the presence of poly(A) tracts by binding to oligo(dT) cellulose followed by hybridization with specific gene probes. Representatives of all classes of
J. Popowski +6 more
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Alternative cleavage and polyadenylation in health and disease
Nature reviews genetics, 2019Andreas J. Gruber, M. Zavolan
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