Results 31 to 40 of about 65,820 (278)
Specificity factors in cytoplasmic polyadenylation [PDF]
WIREs RNA, 2013 Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development. In recent years, however, has been implicated in many other processes, including synaptic plasticity and mitosis.
Charlesworth, A. +2 more
openaire +6 more sources
Advanced Science, 2021 The CCR4‐NOT complex is a major mRNA deadenylase in eukaryotes, comprising the catalytic subunits CNOT6/6L and CNOT7/8, as well as CNOT4, a regulatory subunit with previously undetermined functions.
Xing‐Xing Dai +11 more
doaj +1 more source
Inference of the human polyadenylation code [PDF]
Bioinformatics, 2017 Abstract Motivation Processing of transcripts at the 3′-end involves cleavage at a polyadenylation site followed by the addition of a poly(A)-tail. By selecting which site is cleaved, the process of alternative polyadenylation enables genes to produce transcript isoforms with different 3′-ends.
Leung, Michael K. K. +2 more
openaire +4 more sources
Frontiers in Cellular Neuroscience, 2019 Alternative polyadenylation (APA) is a widespread mechanism involving about half of the expressed genes, resulting in varying lengths of the 3′ untranslated region (3′UTR).
Elena Grassi +13 more
doaj +1 more source
eLife, 2020 Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Matthew T Parker +8 more
doaj +1 more source
A multispecies polyadenylation site model [PDF]
BMC Bioinformatics, 2013 Polyadenylation is present in all three domains of life, making it the most conserved post-transcriptional process compared with splicing and 5'-capping. Even though most mammalian poly(A) sites contain a highly conserved hexanucleotide in the upstream region and a far less conserved U/GU-rich sequence in the downstream region, there are many ...
Samuel I. Gunderson +2 more
openaire +3 more sources
Alternative Polyadenylation: a new frontier in post transcriptional regulation
Biomarker Research, 2020 Polyadenylation of pre-messenger RNA (pre-mRNA) specific sites and termination of their downstream transcriptions are signaled by unique sequence motif structures such as AAUAAA and its auxiliary elements.
F. Ren +4 more
semanticscholar +1 more source
Intragenic CpG Islands and Their Impact on Gene Regulation
Frontiers in Cell and Developmental Biology, 2022 The mammalian genome is depleted in CG dinucleotides, except at protected regions where they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as transcription initiation sites and are as expected, associated with gene promoters ...
James A. Cain +2 more
doaj +1 more source
Alterations in polyadenylation and its implications for endocrine disease
Frontiers in Endocrinology, 2013 IntroductionPolyadenylation is the process in which the pre-mRNA is cleaved at the poly(A) site and a poly(A) tail is added - a process necessary for normal mRNA formation.
Anders eRehfeld +3 more
doaj +1 more source
Birth of a poly(A) tail: mechanisms and control of mRNA polyadenylation
FEBS Open Bio, 2023 During their synthesis in the cell nucleus, most eukaryotic mRNAs undergo a two‐step 3′‐end processing reaction in which the pre‐mRNA is cleaved and released from the transcribing RNA polymerase II and a polyadenosine (poly(A)) tail is added to the newly
Juan B. Rodríguez‐Molina +1 more
doaj +1 more source