Results 31 to 40 of about 104,090 (284)
Tumor Biology, 2017 Glioma is an aggressive malignancy with limited effective treatment and poor prognosis. Cytoplasmic polyadenylation element binding protein 4 is a regulator of gene transcription and has been reported to be associated with biological malignancy in ...
Liu Zhijun +5 more
doaj +1 more source
Frontiers in Genetics, 2019 The length of untranslated regions at the 3′ end of transcripts (3′UTRs) is regulated by alternate polyadenylation (APA). 3′UTRs contain regions that harbor binding motifs for regulatory molecules. However, the mechanisms that coordinate the 3′UTR length
Benjamin J. Harrison +14 more
doaj +1 more source
Virulence- and signaling-associated genes display a preference for long 3′UTRs during rice infection and metabolic stress in the rice blast fungus [PDF]
, 2019 Generation of mRNA isoforms by alternative polyadenylation (APA) and their involvement in regulation of fungal cellular processes, including virulence, remains elusive.
Demuez, Marie +5 more
core +1 more source
Insects, 2022 During the messenger RNA (mRNA) maturation process, RNA polyadenylation is a key step, and is coupled to the termination of transcription. Various cis-acting elements near the cleavage site and their binding factors would affect the process of ...
Liying Fang +4 more
doaj +1 more source
PLoS Genetics, 2018 The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3’ UTRs.
Seth D. Kasowitz +8 more
semanticscholar +1 more source
RNA binding protein Caprin-2 is a pivotal regulator of the central osmotic defense response
eLife, 2015 In response to an osmotic challenge, the synthesis of the antidiuretic hormone arginine vasopressin (AVP) increases in the hypothalamus, and this is accompanied by extension of the 3′ poly(A) tail of the AVP mRNA, and the up-regulation of the expression ...
Agnieszka Konopacka +4 more
doaj +1 more source
Sequence Determinants for Nuclear Retention and Cytoplasmic Export of mRNAs and lncRNAs
Frontiers in Genetics, 2018 Eukaryotes are divided into two major compartments: the nucleus where RNA is synthesized and processed, and the cytoplasm, where mRNA is translated into proteins.
Alexander F. Palazzo, Eliza S. Lee
doaj +1 more source
Components required for in vitro cleavage and polyadenylation of eukaryotic mRNA [PDF]
, 1988 We have studied in vitro cleavage/polyadenylation of precursor RNA containing herpes simplex virus type 2 poly A site sequences and have analysed four RNA/protein complexes which form during in vitro reactions.
Clements, J.B. +3 more
core +1 more source
APAlyzer: a bioinformatics package for analysis of alternative polyadenylation isoforms
Bioinform., 2020 SUMMARY Most eukaryotic genes produce alternative polyadenylation (APA) isoforms. APA is dynamically regulated under different growth and differentiation conditions.
Ruijia Wang, Bin Tian
semanticscholar +1 more source
The transcriptional elongation rate regulates alternative polyadenylation in yeast
eLife, 2020 Yeast cells undergoing the diauxic response show a striking upstream shift in poly(A) site utilization, with increased use of ORF-proximal poly(A) sites resulting in shorter 3’ mRNA isoforms for most genes.
Joseph V Geisberg +2 more
doaj +1 more source