Results 51 to 60 of about 104,144 (317)

PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3′ end sequencing

Nucleic Acids Res., 2019
Generated by 3′ end cleavage and polyadenylation at alternative polyadenylation (poly(A)) sites, alternative terminal exons account for much of the variation between human transcript isoforms.
Christina J. Herrmann, Ralf Schmidt, A. Kanitz, Panu Artimo, Andreas J. Gruber, M. Zavolan   +5 more
semanticscholar   +1 more source

Birth of a poly(A) tail: mechanisms and control of mRNA polyadenylation

FEBS Open Bio, 2023
During their synthesis in the cell nucleus, most eukaryotic mRNAs undergo a two‐step 3′‐end processing reaction in which the pre‐mRNA is cleaved and released from the transcribing RNA polymerase II and a polyadenosine (poly(A)) tail is added to the newly
Juan B. Rodríguez‐Molina, Matti Turtola   +1 more
doaj   +1 more source

Alternative poladenylation of tumor suppressor genes in small intestinal neuroendocrine tumors

Frontiers in Endocrinology, 2014
The tumorigenesis of small intestinal neuroendocrine tumors is poorly understood. Recent studies have associated alternative polyadenylation with proliferation, cell transformation and cancer.
Anders eRehfeld, Mireya ePlass, Kristina eDøssing, Ulrich eKnigge, Andreas eKjaer, Anders eKrogh, Lennart eFriis-Hansen   +6 more
doaj   +1 more source

APAlyzer: a bioinformatics package for analysis of alternative polyadenylation isoforms

Bioinform., 2020
SUMMARY Most eukaryotic genes produce alternative polyadenylation (APA) isoforms. APA is dynamically regulated under different growth and differentiation conditions.
Ruijia Wang, B. Tian
semanticscholar   +1 more source

Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1 [PDF]

, 1994
A gene (X33) localized on human chromosome 1 has been detected by crossreaction of its fusion protein with a monospecific antiserum directed against human vitamin-D-binding protein (hDBP; group-specific component).
Chirgwin, Church, Estaller, Feinberg, Hoffmann, Johnson, Kozak, Manley, McLeod, Meissner, Proudfood, Proudfood, Prunier, Sambrook, Sanger, Sheets, Smith, Tabor, Yanisch-Perron   +18 more
core   +1 more source

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

Nature Communications, 2018
Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects the expression of genes involved in the DNA damage response (DDR) and mRNA processing.
M. Krajewska, Ruben Dries, A. Grassetti, S. Dust, Yang Gao, Hao Huang, Bandana Sharma, Daniel S. Day, Nicholas Kwiatkowski, Monica Pomaville, Oliver Dodd, E. Chipumuro, Tinghu Zhang, A. Greenleaf, Guocheng Yuan, N. Gray, R. Young, M. Geyer, S. Gerber, R. George   +19 more
semanticscholar   +1 more source

Emerging Roles of RNA 3′-end Cleavage and Polyadenylation in Pathogenesis, Diagnosis and Therapy of Human Disorders

Biomolecules, 2020
A crucial feature of gene expression involves RNA processing to produce 3′ ends through a process termed 3′ end cleavage and polyadenylation (CPA). This ensures the nascent RNA molecule can exit the nucleus and be translated to ultimately give rise to a ...
J. Nourse, S. Spada, S. Danckwardt
semanticscholar   +1 more source

Upregulation of Functional Kv11.1 Isoform Expression by Inhibition of Intronic Polyadenylation with Antisense Morpholino Oligonucleotides

, 2012
The KCNH2 gene encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA undergoes alternative processing; intron 9 splicing leads to the formation of a functional, full-length Kv11 ...
Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng   +2 more
core   +2 more sources

The Exosome Subunit Rrp44 Plays a Direct Role in RNA Substrate Recognition [PDF]

, 2007
The exosome plays key roles in RNA maturation and surveillance, but it is unclear how target RNAs are identified. We report the functional characterization of the yeast exosome component Rrp44, a member of the RNase II family.
Anderson, James T., Schneider, Claudia, Tollervey, David   +2 more
core   +2 more sources

Recognition of polyadenylation sites in yeast pre-mRNAs by cleavage and polyadenylation factor [PDF]

The EMBO Journal, 2001
Recognition of poly(A) sites in yeast pre-mRNAs is poorly understood. Employing an in vitro cleavage system with cleavage and polyadenylation factor (CPF) and cleavage factor IA we show that the efficiency and positioning elements are dispensable for poly(A)-site recognition within a short CYC1 substrate in vitro.
Dichtl, B., Keller, W.
openaire   +4 more sources