Results 61 to 70 of about 57,483 (236)
5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng +14 more
wiley +1 more source
Life and Death of mRNA Molecules in Entamoeba histolytica
Frontiers in Cellular and Infection Microbiology, 2018 In eukaryotic cells, the life cycle of mRNA molecules is modulated in response to environmental signals and cell-cell communication in order to support cellular homeostasis.
Jesús Valdés-Flores +5 more
doaj +1 more source
Scientific Reports, 2021 Transposable elements cause alternative splicing (AS) in different ways, contributing to transcript diversification. Alternative polyadenylation (APA), one of the AS events, is related to the generation of mRNA isoforms in 70% of human genes.
Hyeon-Mu Cho +7 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon +12 more
wiley +1 more source
Deciphering the impact of genetic variation on human polyadenylation using APARENT2
Genome Biology, 2022 Background 3′-end processing by cleavage and polyadenylation is an important and finely tuned regulatory process during mRNA maturation. Numerous genetic variants are known to cause or contribute to human disorders by disrupting the cis-regulatory code ...
Johannes Linder +3 more
doaj +1 more source
Patterns of Polyadenylation Site Selection in Gene Constructs Containing Multiple Polyadenylation Signals [PDF]
Molecular and Cellular Biology, 1988 We have constructed a series of plasmids containing multiple polyadenylation signals downstream of the herpes simplex virus type 1 (HSV) thymidine kinase (tk)-coding region. The signals used were from the simian virus 40 (SV40) late gene, the HSV tk gene, and an AATAAA-containing segment of the SV40 early region.
R M, Denome, C N, Cole
openaire +2 more sources
Developmental Dynamics, EarlyView.Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff +6 more
wiley +1 more source
Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology
Developmental Dynamics, EarlyView.Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley +1 more source
Coordination of alternative splicing and alternative polyadenylation revealed by targeted long read sequencing [PDF]
, 2023 Zhiping Zhang +3 more
openalex +1 more source
Pest Management Science, EarlyView.RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden +3 more
wiley +1 more source