Results 111 to 120 of about 68,313 (291)

Study on the relationship between the changes in polyamine content and seedless grapes embryo rescue breeding

Frontiers in Plant Science
This study was envisaged to investigate the physiological reasons affecting the embryo development and abortion of seedless grapes on the basis of the previous embryo rescue breeding techniques of seedless grapes.
Guirong Li, Guirong Li, Kaiwei Li, Feifei Han, Huanchao Gao, Ling Wang, Ling Wang   +6 more
doaj   +1 more source

Exploring polyamines: Functions in embryo/fetal development

Animal Nutrition, 2017
Polyamines such as putrescine, spermidine, spermine and agmatine are aliphatic polycationic compounds present in all living cells, and are derived from amino acids, intestinal bacteria, exfoliated enterocytes and supported from diet.
Tarique Hussain, Bi'e Tan, Wenkai Ren, Najma Rahu, Dildar Hussain Kalhoro, Yulong Yin   +5 more
doaj   +1 more source

Putrescine alleviates cold injury in peach fruit via elevating the conjugated polyamines in tonoplast and thereby maintaining vacuole conformation

Horticultural Science
Exogenous polyamines can elevate postharvest fruit cold resistance and alleviate cold injury. However, the mechanism, by which polyamines mediate cold tolerance, is still to be explored.
Huaipan Liu, Dongxiao Liu
doaj   +1 more source

Role of Polyamines in Immune Cell Functions

Medical Sciences, 2018
The immune system is remarkably responsive to a myriad of invading microorganisms and provides continuous surveillance against tissue damage and developing tumor cells.
Rebecca S. Hesterberg, John L. Cleveland, Pearlie K. Epling-Burnette   +2 more
doaj   +1 more source

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, EarlyView.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source

The influence of chemical polyamines analogs, decarboxylated ornithine and s-(adenosyl)-methionine on the polyamine synthsis velocity in test-systems from tissues with high proliferation

RUDN Journal of Medicine, 2010
The aliphatic (amino)- and (oxy)-derivatives of polyamines effect on the rate of polyamines (Putrescine, Spermidine and Spermine) synthesis in cell-free test-systems from rat's regenerating liver and Hepatoma tissues was examined.
S P Siatkin, Т Т Berezov, T V Fedoronchuk, N Yа Gridina, E A Neborakh, N A Shevkhun, N A Sokueva, E V Ustinova, R I Sokuev   +8 more
doaj  

Increased polyamines alter chromatin and stabilize autoantigens in autoimmune diseases

Frontiers in Immunology, 2013
Polyamines are small cations with unique combinations of charge and length that give them many putative interactions in cells. Polyamines are essential since they are involved in replication, transcription, translation, and stabilization of macro ...
Wesley H. Brooks
doaj   +1 more source

Inositol and Berberine Synergistically Reprogram Endocrine and Ovarian Metabolism in Polycystic Ovary Syndrome

Cell Proliferation, EarlyView.
In a DHEA+HFD‐induced mouse model, Ins/BBR alleviated mitochondrial defects and broadly reprogrammed metabolic landscape in granulosa cells, in specific, restoring nucleotide pools and amino acid turnover, and preventing abnormal long‐chain fatty acid accumulation.
Juan Ge, Chenxiang Zhang, Yilong Zhao, Haiyang Zhao, Shuai Zhu, Tao Tang, Guorui Zhang, Qiang Wang, Hui Wang   +8 more
wiley   +1 more source

Interactions Between Spermine-Derivatized Tentacle Porphyrins And The Human Telomeric DNA G-Quadruplex [PDF]

, 2018
G-rich DNA sequences have the potential to fold into non-canonical G-Quadruplex (GQ) structures implicated in aging and human diseases, notably cancers.
Chen, Jessica, , \u2717, D\u27Urso, A., Gangemi, C. M. A., Lee, Joo Hyun, , \u2717, Sabharwal, Navin C., , \u2714, Yatsunyk, Liliya A.   +5 more
core   +1 more source

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, EarlyView.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source