Results 221 to 230 of about 29,556 (259)
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Essays in Biochemistry, 2009
The polyamines are essential for a variety of functions in the mammalian cell. Although their specific effects have not been fully elucidated, it is clear that the cellular polyamines have to be kept within certain levels for normal cell function.
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The polyamines are essential for a variety of functions in the mammalian cell. Although their specific effects have not been fully elucidated, it is clear that the cellular polyamines have to be kept within certain levels for normal cell function.
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Polyamines and Polyamine Biosynthesis in Cells Exposed to Hyperthermia
Radiation Research, 1983The issue of how polyamines act to sensitize cultured cells to the lethal effects of hyperthermia was investigated using Chinese hamster cells which were induced to express thermotolerance. Intracellular levels of these naturally occurring polycations were manipulated in certain situations by treating whole cells with methylglyoxal bis-(guanylhydrazone)
E W, Gerner +3 more
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Polyamines and polyamine amides from wasps and spiders
Biochemical Society Transactions, 1994Introduction One of the aims of our research programme is to determine the molecular architecture of the ion channel buried deep within certain subtypes of glutamic acid-gated receptor (GluR), i.e. ionotropic not metabotropic GluR. This will require an interdisciplinary approach, but selective pharmacological tools are now available with which to begin
I S, Blagbrough, E, Moya, S, Taylor
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1987
PAs are intracellular regulators of growth and anabolic processes. Toxic properties of PAs are conferred according to the increasing number of cationic charges. In uremia, PA accumulation occurs both in and outside the cell. Decreased PA synthesis and blunted PA pathway responses suggest PAs may participate in cellular down regulation.
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PAs are intracellular regulators of growth and anabolic processes. Toxic properties of PAs are conferred according to the increasing number of cationic charges. In uremia, PA accumulation occurs both in and outside the cell. Decreased PA synthesis and blunted PA pathway responses suggest PAs may participate in cellular down regulation.
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Inhibition of polyamine and spermine oxidases by polyamine analogues
The FEBS Journal, 2006Polyamine oxidase (PAO) and spermine oxidase (SMO) are involved in the catabolism of polyamines – basic regulators of cell growth and proliferation. The discovery of selective inhibitors of PAO and SMO represents an important tool in studying the involvement of these enzymes in polyamine homeostasis and a starting point for the development of novel ...
Bianchi, M. +6 more
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2011
Polyamines are organic cations shown to control gene expression at the transcriptional, posttranscriptional, and translational levels. Multiple cellular oncogenic pathways are involved in regulation of transcription and translation of polyamine-metabolizing enzymes.
Edwin A, Paz +2 more
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Polyamines are organic cations shown to control gene expression at the transcriptional, posttranscriptional, and translational levels. Multiple cellular oncogenic pathways are involved in regulation of transcription and translation of polyamine-metabolizing enzymes.
Edwin A, Paz +2 more
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Archives of Dermatology, 1979
In this issue of theArchives(page 945), Proctor et al report additional data that strongly support the proposition that polyamines may be of importance in the pathophysiology of psoriasis. Since polyamines play a key role in cell proliferation, a potentially productive approach to psoriasis therapy may be the inhibition of polyamine production in ...
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In this issue of theArchives(page 945), Proctor et al report additional data that strongly support the proposition that polyamines may be of importance in the pathophysiology of psoriasis. Since polyamines play a key role in cell proliferation, a potentially productive approach to psoriasis therapy may be the inhibition of polyamine production in ...
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Biochemistry of the polyamines
Cell Biochemistry and Function, 1983AbstractThe naturally‐occurring polyamines exist in the free form, as N‐acetyl derivatives and bound to protein. Their biosynthesis is subject to sensitive control, particularly of ornithine decarboxylase. This enzyme may be multifunctional and a key regulatory protein.
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Dietary Polyamine Intake and Polyamines Measured in Urine
Nutrition and Cancer, 2014Dietary polyamines have recently been associated with increased risk of pre-malignant colorectal lesions. Because polyamines are synthesized in cells and taken up from dietary sources, development of a biomarker of exposure is challenging. Excess polyamines are primarily excreted in the urine.
Ashley J, Vargas +4 more
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Digestion, 2009
Currently, two major pathways are distinguished along which the polyamines are metabolized: the interconversion pathway and the so-called terminal polyamine catabolism. In vertebrates, the interconversion pathway is a cyclic process which controls polyamine turnover.
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Currently, two major pathways are distinguished along which the polyamines are metabolized: the interconversion pathway and the so-called terminal polyamine catabolism. In vertebrates, the interconversion pathway is a cyclic process which controls polyamine turnover.
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