Results 241 to 250 of about 44,703 (290)
Some of the next articles are maybe not open access.
Chromatin remodeling by polyamines and polyamine analogs
Amino Acids, 2013Natural polyamines are involved in many molecular processes, including maintenance of DNA structure and RNA processing and translation. Our aim here is to present an overview of the literature concerning the significance of polyamines in the modulation of chromatin arrangement and the transcriptional regulation of gene expression.
PASINI, ALICE +2 more
openaire +3 more sources
Polyamines and Their Role in Virus Infection
Microbiology and Molecular Biology Reviews, 2017 SUMMARY Polyamines are small, abundant, aliphatic molecules present in all mammalian cells. Within the context of the cell, they play a myriad of roles, from modulating nucleic acid conformation to promoting cellular ...
Marco Vignuzzi +2 more
exaly +2 more sources
Journal of Chromatography B: Biomedical Sciences and Applications, 1982
Putrescine, spermidine, spermine and their derivatives are considered to be potential markers of certain diseases. Routine methods have, therefore, been developed in the course of the last decade. Several automated liquid chromatographic and gas chromatographic methods are presently at our disposal, which meet the practical requirements of sensitivity ...
openaire +2 more sources
Putrescine, spermidine, spermine and their derivatives are considered to be potential markers of certain diseases. Routine methods have, therefore, been developed in the course of the last decade. Several automated liquid chromatographic and gas chromatographic methods are presently at our disposal, which meet the practical requirements of sensitivity ...
openaire +2 more sources
Development of Polyamine Lassos as Polyamine Transport Inhibitors
ACS Medicinal Chemistry Letters, 2022Nine- and twelve-membered triaza-macrocycles were appended to one end of homospermidine to make polyamine lassos. These compounds were shown to be potent polyamine transport inhibitors (PTIs) using pancreatic ductal adenocarcinoma L3.6pl cells, which have high polyamine transport activity. The smaller triazacyclononane-based lasso significantly reduced
Aiste Dobrovolskaite +3 more
openaire +2 more sources
Molecular Biotechnology, 1999
The polyamines spermine, spermidine, and putrescine are small organic molecules one or more of which are present in all living organisms. Many natural products contain polyamine residues. Polyamines are synthesized by a highly regulated pathway from arginine or ornithine and also can be transported in and out of cells.
openaire +2 more sources
The polyamines spermine, spermidine, and putrescine are small organic molecules one or more of which are present in all living organisms. Many natural products contain polyamine residues. Polyamines are synthesized by a highly regulated pathway from arginine or ornithine and also can be transported in and out of cells.
openaire +2 more sources
Biosynthesis of polyamines and polyamine-containing molecules
Biochemical Journal, 2016Polyamines are evolutionarily ancient polycations derived from amino acids and are pervasive in all domains of life. They are essential for cell growth and proliferation in eukaryotes and are essential, important or dispensable for growth in bacteria.
openaire +2 more sources
Recueil des Travaux Chimiques des Pays-Bas, 1936
AbstractThe high boiling amines, obtained by the interaction of 1: 3‐dibromo‐propane and 1: 2‐diamino‐ethane hydrate, have been investigated. The lower terms contain straight chains of dimethylene and trimethylene groups separated by nitrogen atoms but in the higher boiling fractions cyclic amines are present.
openaire +1 more source
AbstractThe high boiling amines, obtained by the interaction of 1: 3‐dibromo‐propane and 1: 2‐diamino‐ethane hydrate, have been investigated. The lower terms contain straight chains of dimethylene and trimethylene groups separated by nitrogen atoms but in the higher boiling fractions cyclic amines are present.
openaire +1 more source
Essays in Biochemistry, 2009
The polyamines are essential for a variety of functions in the mammalian cell. Although their specific effects have not been fully elucidated, it is clear that the cellular polyamines have to be kept within certain levels for normal cell function.
openaire +2 more sources
The polyamines are essential for a variety of functions in the mammalian cell. Although their specific effects have not been fully elucidated, it is clear that the cellular polyamines have to be kept within certain levels for normal cell function.
openaire +2 more sources
Polyamine Oxidases and Oxidized Polyamines
2021Polyamine oxidases that act at the secondary amino group would be further subdivided according to whether diaminopropane or aminopropionaldehyde were among the products. The highest specific activity was found in the peroxisomal fraction, where its presence has been confirmed histochemically in both rat liver and kidney, although polyamine oxidase was ...
openaire +1 more source
Journal of Bacteriology, 1977
Polyamines were determined by n-butanol extraction and thin-layer chromatography in four trypanosomatids: Trypanosoma brucei (rat infection) and cultures of Crithidia fasciculata, Leptomonas sp., and Trypanosoma mega. All had putrescine and spermidine but no detectable spermine.
C J, Bacchi, G Y, Lipschik, H C, Nathan
openaire +2 more sources
Polyamines were determined by n-butanol extraction and thin-layer chromatography in four trypanosomatids: Trypanosoma brucei (rat infection) and cultures of Crithidia fasciculata, Leptomonas sp., and Trypanosoma mega. All had putrescine and spermidine but no detectable spermine.
C J, Bacchi, G Y, Lipschik, H C, Nathan
openaire +2 more sources