Results 41 to 50 of about 40,055 (282)

Polyamines mediate cellular energetics and lipid metabolism through mitochondrial respiration to facilitate virus replication.

PLoS Pathogens
Polyamines are critical cellular components that regulate a variety of processes, including translation, cell cycling, and nucleic acid metabolism. The polyamines, putrescine, spermidine, and spermine, are found abundantly within cells and are positively-
Yazmin E Cruz-Pulido, Natalie J LoMascolo, Delaina May, Jomana Hatahet, Caroline E Thomas, Andrea K W Chu, Samantha P Stacey, Maria Del Mar Villanueva Guzman, Gregory Aubert, Bryan C Mounce   +9 more
doaj   +1 more source

Novel Insight into the Multiple Biological Characteristics of Polyamines in the Gut: From Structure to Function

Frontiers in Bioscience-Landmark
This review explores the structure of polyamines, including putrescine, spermidine, and spermine, and their crucial roles in immune cell functions. Polyamines are active compounds derived from ornithine that regulate signaling pathways by interacting ...
Xinyi Yu, Shuzi Xin, Xiaohui Liu, Luming Pan, Weikai Shi, Yize Li, Hongli Wang, Xin Lu, Han Gao, Jingdong Xu   +9 more
doaj   +1 more source

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source

Natural polyamines stimulate G-proteins [PDF]

, 1992
peer reviewedThe natural polyamines spermine and spermidine, the biosynthetic precursor putrescine and their analogues cadaverine and tyramine stimulate the GTPase activity of purified GTP-binding proteins (Go/Gi) from calf brain reconstituted into ...
Mousli, M., BUEB, Jean-Luc, Da Silva, A., Landry, Y.   +3 more
core   +1 more source

Beyond the Fixed Charge: A New On‐Tissue Derivatisation Strategy Employing Photoionisable Chromophores for Mass Spectrometry Imaging of Amino‐Containing Metabolites

Angewandte Chemie, EarlyView.
We introduce a novel chemical derivatisation strategy for the UV‐activated detection of elusive metabolites. Incorporation of a tocopherol‐active chromophore allows for the detection of tagged analytes as photoionised radical cations, selectively induced by a 266 nm laser.
Sofia R. McGowan, Andrew J. Tague, Ashna A. Kumar, Marie Ranson, Christopher J. T. Hyland, Shane R. Ellis   +5 more
wiley   +2 more sources

Effects of polyamines on Vibrio cholerae virulence properties. [PDF]

PLoS ONE, 2013
Vibrio cholerae is the causative agent of the severe enteric disease cholera. To cause cholera the bacterium must be able to synthesize both cholera toxin (CT) and toxin-coregulated pilus (TCP) which mediates autoagglutination and is required for ...
John Bradley Goforth, Nicholas Emmanuel Walter, Ece Karatan   +2 more
doaj   +1 more source

Improvement of plant regeneration efficiency using polyamines for double haploid production in wheat (Triticum aestivum)

The Indian Journal of Agricultural Sciences, 2022
Polyamines are low molecular weight nitrogen containing compounds present in all living organisms. These are considered to be a new class of plant hormones, and play a positive role in plant growth and developmental processes including cell division, in
PRINKA GOYAL, S K THIND, PUJA SRIVASTAVA, ACHLA SHARMA   +3 more
doaj   +1 more source

Polyamine-Based Nanostructures Share Polyamine Transport Mechanisms with Native Polyamines and Their Analogues: Significance for Polyamine-Targeted Therapy

Medical Sciences, 2022
Polyamines are small polycationic alkylamines involved in many fundamental cellular processes, including cell proliferation, survival, and protection from oxidative stress. Polyamine homeostasis is tightly regulated through coordinated biosynthesis, catabolism, and transport.
Cassandra E. Holbert, Jackson R. Foley, Ao Yu, Tracy Murray Stewart, Otto Phanstiel, David Oupicky, Robert A. Casero   +6 more
openaire   +3 more sources

Water Permeates and Plasticizes Amorphous Carbon Dots: Unraveling the Inner Accessibility of the Nanoparticles by Glass Transition Studies

Advanced Materials, EarlyView.
The water permeability of amorphous carbon dots (CDs) is demonstrated by investigating their plasticization. Novel polyamide‐based and amorphous nanoparticles are synthesized by controlling their inner packing density. Water plasticization is evidenced by the decrease of the CDs glass transition temperature with increasing the hydration degree.
Elisa Sturabotti, Valerio Di Lisio, Lucia Cardo, Alessandro Camilli, Estela Moretón Alfonsín, Daniele Cangialosi, Amaia Iturrospe Ibarra, Arantxa Arbe, Maurizio Prato   +8 more
wiley   +1 more source

Novel asymmetric naphthalenediimide-polyamines conjugates as anticancer agents. [PDF]

, 2012
As the number of cases of cancer increases worldwide there is a need to develop better and more selective anticancer agents. Naphtalenediimide (NDI) scaffold is present in a wide number of anticancer agents which interact with DNA preferentially as ...
V Tumiatti, Huanzhou, A Milelli, ML Greco, C Sissi, H M Wallace, Minarini A   +6 more
core