Results 41 to 50 of about 44,703 (290)

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Physiological importance of polyamines [PDF]

, 2017
Polyamines are polycationic molecules that contain two or more amino groups (-NH3 +) and are present in all eukaryotic and prokaryotic cells. Polyamines are synthesized from arginine, ornithine, and proline, and from methionine as the methyl-group donor.
Lenis, Yasser Y., Fuller W. Bazer, Bazer, Fuller W., Elmetwally, Mohammed A., Yasser Y. Lenis, Maldonado-Estrada, Juan G., Mohammed A. Elmetwally, Juan G. Maldonado-Estrada   +7 more
core   +1 more source

Process for producing polyamines

, 2009
The present invention relates to a process for the production of a polyamine involving the use of enzymes; in particular to a process performed in aqueous environment; to the polyamines produced by said method; as well as the use of said polyamines for ...
Hauer, Bernhard, Berglund, Per,, Engelmark Cassimjee, David Karim,   +2 more
core   +7 more sources

Accelerating Phosphate Transport Across Membranes via Synergistic Chemical‐Electrochemical Carriers

Angewandte Chemie, EarlyView.
A new membrane design principle based on synergistic chemical and electrochemical carriers is proposed to construct an electro‐driven carrier‐conducting membrane for high‐throughput phosphate transport. Monodispersed ferrihydrite nanoparticles embedded within the membrane act as built‐in phosphate carriers, enabling accelerated phosphate migration via ...
Lei Xia, Yangbo Qiu, Qingzhi Liu, Mengjiao Guan, Xi Zhang, Raf Dewil, Jin Shang, Yan Zhao, Bart Van der Bruggen, Chuyang Tang   +9 more
wiley   +2 more sources

Efficient Adsorption‐Based Direct Air Capture Via Triply Periodic Minimal Surface Architectures

Advanced Science, EarlyView.
Architected triply periodic minimal surface (TPMS) contactors reshape direct air capture by replacing straight‐channel diffusion limits with convection‐enhanced CO2 transport. Chaotic advection thins boundary layers and exposes fast adsorption sites, enabling 70%–75% more fast sites, 114% higher productivity, and 51.8% lower energy consumption than ...
Qingyang Shao, Zhuozhen Gan, Chengcheng Long, Man Zhang, Yihe Miao, Yuehui Li, Xuancan Zhu   +6 more
wiley   +1 more source

Polyamines and Cancer

, 2017
This chapter provides an overview of how the polyamine pathway has been exploited as a target for the treatment and prevention of multiple forms of cancer, since this pathway is disrupted in all cancers. It is divided into three main sections. The first explores how the polyamine pathway has been targeted for chemotherapy, starting from the first drug ...
Elisabetta, Damiani, Heather M, Wallace
openaire   +2 more sources

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

The effect of polyamines on the expression of olfactory related genes in the diamondback moth, Plutella xylostella (Lepidoptera: Yponomeutidae)

European Journal of Entomology, 2015
Polyamines are nitrogenous compounds that alter the odour sensitivity of insects. The objective of this study was to determine the effects of polyamines on the expression levels of olfactory-related genes in male/female adult diamondback moths, Plutella ...
Zhichun ZHANG, Manqun WANG, Guanghua LUO, Gufeng ZHANG, Jichao FANG   +4 more
doaj   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Nucleosome destabilization by polyamines

, 2022
The roles and molecular interactions of polyamines (PAs) in the nucleus are not fully understood. Here their effect on nucleosome stability, a key regulatory factor in eukaryotic gene control, is reported, as measured in agarose embedded nuclei of H2B ...
Bosire, Rosevalentine, Szabo, Gabor, Nanasi Jr., Peter, Niaki, Erfaneh Firouzi, Jordan, Albert, Bacso, Zsolt, Pommier, Yves, Hamidova, Nubar, Imre, Laszlo, Nagy, Peter, Nánási, Péter Pál ifj., Firouzi Niaki, Erfaneh   +11 more
core   +1 more source