Results 131 to 140 of about 462,629 (365)

Robot‐assisted vs open kidney transplantation from deceased donors

BJU International, EarlyView.
Objectives To test the hypothesis that the type of surgical approach, robot‐assisted kidney transplantation (RAKT) vs open kidney transplantation (OKT), impacts intra‐operative and postoperative surgical outcomes of patients receiving kidney transplantation from deceased donors.
Luca Afferi, Angelo Territo, Alessio Pecoraro, Lorenzo Masieri, Milla Ortved, Julia Abildgaard Dagnæs‐Hansen, Begonya Etcheverry, Andrea Gallioli, Donato Cannoletta, Joris Vangeneugden, Jeremy Mercier, Thomas Prudhomme, Isacco Donnini, Antonino Vazzana, Malene Rohrsted, Francesc Vigués, Nicolas Doumerc, Karel Decaestecker, Joan Palou, Riccardo Campi, Sergio Serni, Andreas Roder, Alberto Breda   +22 more
wiley   +1 more source

Hybrid Repair of a Thoraco-abdominal Aortic Aneurysm Associated with Polycystic Kidney Disease [PDF]

, 2012
IntroductionWe report an incidental finding of a 9.8 cm Crawford type III thoraco-abdominal aortic aneurysm associated with autosomal dominant polycystic kidney disease (ADPKD).Case reportCT imaging revealed a grossly enlarged polycystic liver and right ...
Courtois, N., Kashef, E., Perera, A.H., Wolfe, J.   +3 more
core   +1 more source

Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination

British Journal of Pharmacology, EarlyView.
▪ Background and Purpose NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product with multiple anti‐inflammatory activities, but a narrow therapeutic window ...
Mo‐Yu Ding, Chengqing Ning, Shao‐Ru Chen, Hao‐Ran Yin, Jing Xu, Ying Wang   +5 more
wiley   +1 more source

Food Restriction Ameliorates the Development of Polycystic Kidney Disease.

Journal of the American Society of Nephrology, 2016
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the accumulation of kidney cysts that ultimately leads to loss of renal function and kidney failure.
G. Warner, K. Hein, Verónica Nin, M. Edwards, Claudia C S Chini, K. Hopp, P. Harris, V. Torres, E. Chini   +8 more
semanticscholar   +1 more source

Defining the polycystin pharmacophore through high‐throughput screening and computational biophysics

British Journal of Pharmacology, EarlyView.
An unbiased high throughput electrophysiology screen identifies potent PKD2L1 channel inhibitors with divergent chemical composition that bind to pore fenestration receptors and stabilise their inactivated state. Abstract Background and Purpose Polycystins (PKD2, PKD2L1) are voltage‐gated and Ca2+‐modulated members of the TRP family of ion channels ...
Eduardo Guadarrama, Carlos G. Vanoye, Paul G. DeCaen   +2 more
wiley   +1 more source

Effect of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease by CKD Stage: Results from the TEMPO 3:4 Trial.

American Society of Nephrology. Clinical Journal, 2016
BACKGROUND and objectives The Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes 3:4 study demonstrated a significant beneficial effect of the vasopressin V2 receptor antagonist tolvaptan on rates
V. Torres, E. Higashihara, O. Devuyst, A. Chapman, R. Gansevoort, J. Grantham, R. Perrone, J. Ouyang, J. Blais, F. Czerwiec   +9 more
semanticscholar   +1 more source

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women

Clinical Endocrinology, EarlyView.
ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan, James M. Hawley, Leanne Cussen, Ali Abbara, Sophie A. Clarke, Punith Kempegowda, Rima K. Dhillon‐Smith, Puja Thadani, Maureen Busby, Lucy Owusu‐Darkwah, Rachel Marrington, W. Colin Duncan, Robert K. Semple, Richard Quinton, Michael W. O'Reilly   +14 more
wiley   +1 more source

Fetal polycystic kidney disease: Pathological overview

Journal of the Scientific Society, 2013
Polycystic kidney disease is a rare developmental anomaly inherited as autosomal dominant or autosomal recessive. It is characterized by cystic dilatation of the collecting ducts frequently associated with hepatic involvement and progression to renal ...
Sunita B Patil, Madhura D Paricharak, Deepak G Paricharak, S S More   +3 more
doaj   +1 more source

Refining Genotype-Phenotype Correlation in Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology, 2016
Renal disease variability in autosomal dominant polycystic kidney disease (ADPKD) is strongly influenced by the gene locus (PKD1 versus PKD2). Recent studies identified nontruncating PKD1 mutations in approximately 30% of patients who underwent ...
Y. Hwang, J. Conklin, W. Chan, N. Roslin, Jannel Liu, N. He, Kairong Wang, J. L. Sundsbak, C. M. Heyer, M. Haider, A. Paterson, P. Harris, Y. Pei   +12 more
semanticscholar   +1 more source

Nonobstructing Colonic Dilatation and Colon Perforations Following Renal Transplantation [PDF]

, 1990
Nonobstructing colonic dilatation has not been commonly reported following renal transplantation, and colon perforations carry a high morbidity and mortality in this population.
Hakala, TR, Koneru, B, O'hair, DP, Selby, R, Starzl, TE, Tzakis, AG   +5 more
core   +1 more source