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Polycystic kidney disease [PDF]

Nature Reviews Disease Primers, 2018
Cystic kidneys are common causes of end-stage renal disease, both in children and in adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are cilia-related disorders and the two main forms of monogenic cystic kidney diseases.
Peter C Harris, Shigeo HORIE, Dorien J M Peters   +2 more
exaly   +9 more sources

Polycystic liver and kidney diseases

Annals of Medicine, 2005
There have been remarkable advances in research on polycystic liver and kidney diseases recently, covering cloning of new genes, refining disease classifications, and advances in understanding more about the molecular pathology of these diseases. Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary disease affecting ...
Helena Kääriäinen, Krister Höckerstedt   +1 more
exaly   +3 more sources

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Kynurenines in polycystic kidney disease

Journal of Nephrology, 2022
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary disorder, characterized by kidney cyst formation. A major pathological feature of ADPKD is the development of interstitial inflammation.
Jost, Klawitter, Matthew J, Jackson, Peter H, Smith, Katharina, Hopp, Michel, Chonchol, Berenice Y, Gitomer, Melissa A, Cadnapaphornchai, Uwe, Christians, Jelena, Klawitter   +8 more
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Polycystic Kidney/Liver Disease

Clinics in Liver Disease, 2022
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder that leads to chronic kidney disease and end-stage kidney disease (ESKD). Polycystic liver disease (PCLD) is the most common extrarenal manifestation of ADPKD. Though isolated PCLD and PCLD due to ADPKD are genetically distinct, they follow a similar clinical course of ...
Rebecca, Roediger, Douglas, Dieterich, Pramodh, Chanumolu, Priya, Deshpande   +3 more
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Polycystic Kidney Disease

Comprehensive Physiology, 2017
ABSTRACT Renal cysts, which arise from renal tubules, can be seen in a variety of hereditary and nonhereditary entities. Common mechanisms associated with renal cyst formation include increased cell proliferation, epithelial fluid secretion, and extracellular matrix remodeling. Hereditary polycystic kidney disease
Joseph, Ghata, Benjamin D, Cowley
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Cilia and polycystic kidney disease

Seminars in Cell & Developmental Biology, 2021
Polycystic kidney disease (PKD), comprising autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD), is characterized by incessant cyst formation in the kidney and liver. ADPKD and ARPKD represent the leading genetic causes of renal disease in adults and children, respectively.
openaire   +2 more sources

Polycystic Kidney Disease

New England Journal of Medicine, 2004
Polycystic kidney diseases are inherited renal disorders due mainly to mutations in genes that regulate the development and function of cells that line renal tubules. This review outlines the clinical importance of polycystic kidney diseases and discusses the cell biology and molecular mechanisms that cause the formation of hundreds of cystic lesions ...
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Polycystic kidney disease in a cat

Journal of Small Animal Practice, 1977
ABSTRACTBilateral polycystic kidney disease was diagnosed in a 3‐year‐old female Persian cat. An elevation of blood urea nitrogen, serum creatinine levels, and serum phosphorus were the only abnormalities found with serial serum chemical and urine analyses. Intravenous urography showed radiolucent areas in both kidneys.
J W, Northington, M M, Juliana
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