Baseline characteristics of the Korean genetic cohort of inherited cystic kidney disease [PDF]
Kidney Research and Clinical Practice, 2023 Background Identifying genetic mutations in individuals with inherited cystic kidney disease is necessary for precise treatment. We aimed to elucidate the genetic characteristics of cystic kidney disease in the Korean population. Methods We conducted a 3-
Jeong Min Cho +17 more
doaj +1 more source
p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels. [PDF]
, 2007 BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease with few treatment options other than renal replacement therapy. p21, a cyclin kinase inhibitor which has pleiotropic effects on the cell cycle, in many cases acts
Anderson, Sharon +6 more
core +3 more sources
Polycystic kidney diseases: From molecular discoveries to targeted therapeutic strategies
Cellular and Molecular Life Sciences, 2007 .Polycystic kidney diseases (PKDs) represent a large group of progressive renal disorders characterized by the development of renal cysts leading to end-stage renal disease.
O. Ibraghimov-Beskrovnaya, N. Bukanov
semanticscholar +1 more source
Magnetic resonance imaging 3t and total fibrotic volume in autosomal dominant polycystic kidney disease [PDF]
, 2018 INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal hereditary disorder. Several authors have attempted to identify a kidney damage marker for predicting the prognosis and the effectiveness of therapy in ADPKD ...
Ciccariello, Mauro +9 more
core +1 more source
PeptiCKDdb-peptide- and protein-centric database for the investigation of genesis and progression of chronic kidney disease [PDF]
, 2016 The peptiCKDdb is a publicly available database platform dedicated to support research in the field of chronic kidney disease (CKD) through identification of novel biomarkers and molecular features of this complex pathology.
Fernandes, Marco +8 more
core +8 more sources
MicroRNAs and Polycystic Kidney Disease [PDF]
Drug Discovery Today: Disease Models, 2013 Polycystic kidney disease (PKD), the most common genetic cause of chronic renal failure, is characterized by the presence of numerous fluid-filled cysts in renal parenchyma. Despite recent progress, no FDA-approved therapy is available to retard cyst growth.
Ronak Lakhia +2 more
openaire +4 more sources
Embracing Sex-specific Differences in Engineered Kidney Models for Enhanced Biological Understanding [PDF]
, 2023 In vitro models play a crucial role in advancing our understanding of biological processes, disease mechanisms, and developing screening platforms for drug discovery. Kidneys play an instrumental role in transport and elimination of drugs and toxins.
arxiv +1 more source
Journal of the American Society of Nephrology, 2005 A key feature of the polycystic kidney diseases is aberrant cell proliferation, a consequence of dysfunctional ciliary signaling. The NIMA-related kinases (Nek) Nek1 and Nek8 carry the causal mutations of two of the eight established mouse models of ...
M. Mahjoub, Melissa L Trapp, L. Quarmby
semanticscholar +1 more source
ADAMs family in kidney physiology and pathology
EBioMedicine, 2021 A disintegrin and metalloproteinases (ADAMs) family are proteolytic transmembrane proteases that modulate diverse cell functions and coordinate intercellular communication.
Huanhuan Zhu +4 more
doaj
Diagnosis of pathological conditions of kidney by two-dimensional and three-dimensional ultrasonographic imaging in dogs [PDF]
Veterinary World, 2016 Aim: The objective of the study was to obtain and compare two-dimensional (2D) and three-dimensional (3D) ultrasonographic images of the kidney in different disease conditions.
Dinesh Dehmiwal +5 more
doaj +1 more source