First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide [PDF]
Current Issues in Molecular BiologyPolydeoxyribonucleotide (PDRN) has emerged as a potent bioactive compound with proven efficacy in wound healing, tissue regeneration, and anti-inflammatory applications and is predominantly derived from salmonid gonads.
Jong-Sung Lee, Wonsang Seo
exaly +5 more sources
Adenosine A2A Receptor Agonist, Polydeoxyribonucleotide Treatment Improves Locomotor Function and Thermal Hyperalgesia Following Neuropathic Pain in Rats [PDF]
International Neurourology Journal, 2023 Purpose Lithotomy position has been widely used in the various urologic surgery. Occasionally sensory and motor problems of the lower extremities are occurred due to the lithotomy position and these deficits may be related with sciatic nerve injury (SNI).
Ye Chan Joo +3 more
doaj +4 more sources
Polydeoxyribonucleotide: A promising skin anti-aging agent
Chinese Journal of Plastic and Reconstructive Surgery, 2022 Polydeoxyribonucleotide (PDRN) consists of DNA fragments with molecular weights ranging from 50 to 1 500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon.
Feng Zhou, Haiyan Cui
exaly +4 more sources
Comparison of the effectiveness of extensor muscle strengthening exercise by itself, exercise with polydeoxyribonucleotide injection, and exercise with extracorporeal shockwave therapy in lateral epicondylitis: a randomized controlled trial [PDF]
Clinics in Shoulder and Elbow, 2021 Background Extensor muscle strengthening exercises with counterforce braces (EX) is a conventional conservative treatment for lateral epicondylitis (LE) of the elbow.
Bum Jin Shim +6 more
doaj +3 more sources
Beneficial Effects of Polydeoxyribonucleotide (PDRN) in an In Vitro Model of Fuchs Endothelial Corneal Dystrophy [PDF]
Pharmaceuticals, 2022 Fuchs endothelial corneal dystrophy (FECD) is a bilateral, hereditary syndrome characterized by progressive irreversible injury in the corneal endothelium; it is the most frequent cause for corneal transplantation worldwide.
Ida Ceravolo +9 more
doaj +3 more sources
Polydeoxyribonucleotides Pre-Clinical Findings in Bone Healing: A Scoping Review [PDF]
Dentistry Journal, 2023 Aim: Polydeoxyribonucleotide (PDRN) is a chain-like polymer derived from DNA. Recent in vitro and animal studies have showcased the beneficial impacts of PDRN on the process of bone mending, whether used on its own or in conjunction with other substances
Mattia Manfredini +5 more
doaj +3 more sources
Molecules, 2022 It is well-known that increased oxidative stress caused by ultraviolet B (UV-B) radiation induces melanogenesis and activates metalloproteinases (MMPs), which degrade collagen and elastin fibers, leading to decreased skin elasticity.
Hyoung-Moon Kim, Kyung-A Byun, Seyeon Oh
exaly +3 more sources
Polydeoxyribonucleotide (PDRN) Selectively Promotes Osteoblast Differentiation Without Affecting Osteoclastogenesis [PDF]
Marine DrugsDeveloping novel anabolic agents for bone regeneration remains a clinical priority. Polydeoxyribonucleotide (PDRN) exhibits tissue-regenerative properties, but its direct cellular effects on bone remodeling remain unclear.
Younghoon Jeon +9 more
doaj +2 more sources
Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing
Pharmaceuticals, 2021 The normal wound healing process is characterized by a complex, highly integrated cascade of events, requiring the interactions of many cell types, including inflammatory cells, fibroblasts, keratinocytes and endothelial cells, as well as the involvement
Giovanni Pallio +2 more
exaly +3 more sources
Salvage of Unilateral Complete Ear Amputation with Continuous Local Hyperbaric Oxygen, Platelet-Rich Plasma and Polydeoxyribonucleotide without Micro-Revascularization [PDF]
Archives of Plastic Surgery, 2017 In many cases of complete ear amputation, microvascular surgery is required for tissue perfusion and organ survival. However, microvascular reconstruction is not always feasible in the absence of suitable vessels.
Sang Keon Lee +3 more
doaj +3 more sources