Results 81 to 90 of about 311,496 (336)

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

Raised serum transaminases during treatment with pegylated interferon for chronic hepatiti C [PDF]

, 2016
Introduction : Serum transaminases rose significantly in 7 patients with chronic hepatitis C, genotypes 2 and 3, who were treated with pegylated interferon and ribavirin. Methods : 219 patients with chronic hepatitis C, genotypes 2 and 3, were treated
Datta, S., Mandalou, P., Mills, P.R., Spence, E.   +3 more
core   +1 more source

Synthesis of Silicon Dioxide (SiO₂) Nanowires via a Polyethylene Glycol-Based Emulsion Template Method in Isopropanol. [PDF]

Nanomaterials (Basel)
Typical wet-chemical methods for the preparation of silica nanowires use polyvinylpyrrolidone and n-pentanol. This study presents a polyethylene glycol-based emulsion template method for the synthesis of SiO2 nanowires (SiO2NWs) in isopropanol.
Liu J, Sun Y, Yang T.
europepmc   +2 more sources

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Preparation of Fe₃O₄Spherical Nanoporous Particles Facilitated by Polyethylene Glycol 4000

Nanoscale Research Letters, 2009
Much interest has been attracted to the magnetic materials with porous structure because of their unique properties and potential applications. In this report, Fe3O4nanoporous particles assembled from small Fe3O4nanoparticles have been prepared by ...
Wang Li-Li, Jiang Ji-Sen
doaj   +1 more source

Bowel Preparation for Colonoscopy: A Randomized Controlled Trial Comparing Polyethylene Glycol Solution, One Dose and Two Doses of Oral Sodium Phosphate Solution

Asian Journal of Surgery, 2004
To compare three bowel preparation regimens for colonoscopy in terms of the quality of preparation, the side effects and patient acceptance. Methods: A total of 299 patients who underwent colonoscopy were randomized to three bowel preparation regimens ...
Wai-Lun Law, Hok-Kwok Choi, Kin-Wah Chu, Judy W.C. Ho, Lucia Wong   +4 more
doaj   +1 more source

Characterization of heterogeneity and spatial distribution of phases in complex solid dispersions by thermal analysis by structural characterization and X-ray micro computed tomography [PDF]

, 2016
Purpose: This study investigated the effect of drug-excipient miscibility on the heterogeneity and spatial distribution of phase separation in pharmaceutical solid dispersions at a micron-scale using two novel and complementary characterization ...
Alhijjaj, Muqdad, Belton, Peter, Qi, Sheng, Reading, Mike, Yassin, Samy, Zeitler, J. Axel   +5 more
core   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

A new crystal form of penicillin acylase from Escherichia coli [PDF]

, 1997
A new crystal form of penicillin acylase (penicillin amidohydrolase, E.C. 3.5.1.11) from Escherichia coli W (ATCC 11105) is reported. The crystals were grown using a combination of hanging-drop and streak-seeding methods.
Brannigan, J.A., Done, S.H., McVey, C.E., Tolley, S.P., Wilson, K.S.   +4 more
core   +2 more sources

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source