Results 221 to 230 of about 35,820 (275)
Journal of Nanoscience and Nanotechnology, 2004 For non-viral gene delivery, the carriers for DNA transfer into cells must be vastly improved. The branched cationic polymer polyethylenimine has been described as an efficient gene carrier. However, polyethylenimine was demonstrated to mediate substantial cytotoxicity.
Miriam Breunig +2 more
exaly +4 more sources
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Journal of Controlled Release, 2006
Here a simple in vitro assay was used to investigate the disassembly of nanoparticles of polyethylenimine (PEI) and DNA. Particles were formed with various PEIs, allowed to mature for 10 min, and then exposed to different competitors (RNA, DNA, BSA or heparin) or to different conditions of pH or osmolarity.
Florian Maria Wurm +2 more
exaly +4 more sources
Here a simple in vitro assay was used to investigate the disassembly of nanoparticles of polyethylenimine (PEI) and DNA. Particles were formed with various PEIs, allowed to mature for 10 min, and then exposed to different competitors (RNA, DNA, BSA or heparin) or to different conditions of pH or osmolarity.
Florian Maria Wurm +2 more
exaly +4 more sources
2005
Since the first edition of this book in 1999 the field of gene therapy has been the arena both for major advances that justified the early hopes placed in the concept, and for ever-present impatience with the slowness of overall progress. On the positive side, gene therapy obtained its first brilliant success, though not where most efforts were ...
Barbara, Demeneix, Jean-Paul, Behr
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Since the first edition of this book in 1999 the field of gene therapy has been the arena both for major advances that justified the early hopes placed in the concept, and for ever-present impatience with the slowness of overall progress. On the positive side, gene therapy obtained its first brilliant success, though not where most efforts were ...
Barbara, Demeneix, Jean-Paul, Behr
openaire +6 more sources
Journal of Polymer Science Part A-1: Polymer Chemistry, 1972
AbstractPolyethylenimine (PEI) has been oxidized with aqueous hydrogen peroxide to yield a hygroscopic, water‐soluble, slightly basic, yellow polymeric solid (OPEI) containing about 25% oxygen. Some chain degradation accompanies oxidation. The nature of the product varies somewhat with preparative conditions.
Howard C. Haas +2 more
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AbstractPolyethylenimine (PEI) has been oxidized with aqueous hydrogen peroxide to yield a hygroscopic, water‐soluble, slightly basic, yellow polymeric solid (OPEI) containing about 25% oxygen. Some chain degradation accompanies oxidation. The nature of the product varies somewhat with preparative conditions.
Howard C. Haas +2 more
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Characterization of Polyethylenimine
Journal of Macromolecular Science: Part A - Chemistry, 1970Abstract Polymerization of anhydrous ethylenimine proceeds to completion with destruction of the terminal 1-aziridinyl group at relatively low molecular weight. In the absence of evidence for end groups, it is suggested that the chain terminating process is the formation of large rings composed of repeating CzHs N units.
C. R. Dick, G. E. Ham
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Protonation of Polyethylenimine
Journal of Macromolecular Science: Part A - Chemistry, 1986Abstract Protonation of polyethylenimine (PEI) has been studied by various investigators [1–41. Most studies involved potentiometric titrations with hydrochloric acid and the effect of added salts. Liu [51 has reported the specific influence of chloride, bromide, and nitrate ions on the viscosity of solutions of protonated PEL It has been noticed that,
Do Ren Chang, Sara Harden, Nick Loverro
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Gene transfer with lipospermines and polyethylenimines
Advanced Drug Delivery Reviews, 1998It is an obvious and basic principle that to be efficient, gene therapy requires effective gene transfer followed by adequate gene expression. However, getting DNA, a pro-drug, into the cell and into the nucleus, remains a crucially limiting factor. Even recombinant viral methods still show poor performances in clinical situations and non-viral methods
Remy, Jean-Serge +5 more
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Enhanced Gene Transfection Efficiency by Low-Dose 25 kDa Polyethylenimine by the Assistance of 1.8 kDa Polyethylenimine [PDF]
Drug Delivery, 2018 Gene therapy is a promising strategy for treatments of various diseases. Efficient and safe introduction of therapeutic genes into targeted cells is essential to realize functions of the genes. High-molecular-weight polyethylenimines (HMW PEIs) including 25 kDa branched PEI and 22 kDa linear PEI are widely used for in vitro gene transfection.
Meng Du, Zhiyi Chen, Yuhao Chen
exaly +4 more sources
Uptake and Intracellular Fate of Polyethylenimine in Vivo
Biochemical and Biophysical Research Communications, 2000Branched polyamines are extensively used as nonviral vectors for plasmid DNA in transfection experiments. Moreover, recently it has been shown that these compounds are able to eliminate prions from infected cells in cultures. It has been proposed that in both cases endosomes or lysosomes are the site of action.
Lecocq, Michèle +4 more
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Polyethylenimine adsorption by cellulose
Journal of Applied Polymer Science, 1976The behavior of cellulose materials in aqueous solutions of polyethylenimine was investigated. Sulfite-bleached cellulose, sulfite unbleached, sulfate unbleached, and monocarboxylcellulose were used. The adsorption kinetics of polyethylenimine by monocarboxylcellulose were studied in detail.
Margarita Petkova Nedelcheva +1 more
openaire +1 more source