Results 51 to 60 of about 35,820 (275)

Analysis of Polymer/siRNA Nanoparticle Efficacy and Biocompatibility in 3D Air–Liquid Interface Culture Compared to 2D Cell Culture

Pharmaceutics
Background: Polymeric nanoparticles have been explored as efficient tools for siRNA delivery to induce RNAi-mediated gene knockdown. Chemical modifications of polyethylenimines (PEI) enhance nanoparticle efficacy and biocompatibility.
Sandra Noske, Martin Krueger, Alexander Ewe, Achim Aigner   +3 more
doaj   +1 more source

Polyethylenimine-Modified Membranes for CO₂ Capture and in Situ Hydrogenation

, 2018
Enzymatic CO2 reduction can provide value-added chemicals from greenhouse gases at ambient temperature and pressure. However, poor solubility of CO2 results in a low conversion rate.
Yongzhen Chen (2901503), Jing Sun (141206), Yongzhen Chen, Jing Sun, Caihong Wang (535816), Wenfang Liu, Zhiping Zhao (779373), Yanzi Wang, Caihong Wang, Zhiping Zhao, Wenfang Liu (1857946), Yanzi Wang (285196)   +11 more
core   +1 more source

Aerosolized BC-819 inhibits primary but not secondary lung cancer growth. [PDF]

, 2011
Despite numerous efforts, drug based treatments for patients suffering from lung cancer remains poor. As a promising alternative, we investigated the therapeutic potential of BC-819 for the treatment of lung cancer in mouse tumor models.
Corinna Pfeifer, Patricia Ohana, Wagner Kai, Carsten Rudolph, Aneja, Manish Kumar, Gilon, Michal, Hochberg, Avraham, Pfeifer, Corinna, Ohana, Patricia, Hasenpusch, Günther, Kai Wagner, Günther Hasenpusch, Gilon Michal, Ohana Patricia, Rudolph, Carsten, Michal Gilon, Hasenpusch Günther, Manish Kumar Aneja, Pfeifer Corinna, Avraham Hochberg, Reinhardt Dietrich, Wagner, Kai, Reinhardt, Dietrich, Aneja Manish Kumar, Hochberg Avraham, Rudolph Carsten, Dietrich Reinhardt   +26 more
core   +2 more sources

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

Preparation of Hydrocortisone Conjugated Polyethylenimine Nanocarriers and its Characterizations for Potential Application in Targeted Gene Delivery [PDF]

Journal of Advanced Biomedical Sciences, 2019
Background & objective: nowadays, gene therapy has been considered as a novel therapeutic approach. Particularly, following the introduction of immunotherapy and gene editing using CRISPR/Cas9 platform great attention has been directed to gene therapy ...
Hossein Sadeghpour, Elaheh Sabet, Ali Dehshahri   +2 more
doaj  

Biodegradable Carriers for Delivery of VEGF Plasmid DNA for the Treatment of Critical Limb Ischemia

Frontiers in Pharmacology, 2017
The safe and efficient delivery of therapeutic nucleic acid is a prerequisite for an effective DNA therapy. In this study, we condensed the low molecular weight polyethylenimine (PEI, 1.8k Da) with 2,6-pyridinedicarboxaldehyde (PDA), both of which are ...
Guang Liu, Zhiwei Fang, Minglu Yuan, Weimin Li, Yunqi Yang, Mier Jiang, Yuanming Ouyang, Weien Yuan   +7 more
doaj   +1 more source

Evaluation of the Cytotoxicity of Cationic Polymers on Glioblastoma Cancer Stem Cells

Journal of Functional Biomaterials, 2022
Cationic polymers such as polyethylenimine (PEI) have found a pervasive place in laboratories across the world as gene delivery agents. However, their applications are not limited to this role, having found a place as delivery agents for drugs, in ...
Conor McCartin, Juliette Blumberger, Candice Dussouillez, Patricia Fernandez de Larrinoa, Monique Dontenwill, Christel Herold-Mende, Philippe Lavalle, Béatrice Heurtault, Stéphane Bellemin-Laponnaz, Sylvie Fournel, Antoine Kichler   +10 more
doaj   +1 more source

Polyethylenimine-Modified Zeolite 13X for CO₂ Capture: Adsorption and Kinetic Studies

, 2019
A class of high molecular weight polyethylenimine (PEI)-modified zeolite 13X adsorbents were synthesized by varying the concentration of imines and screened for preliminary investigation of CO2 capture studies.
Ujjwal Pal (1534174), Sudarshan Kodukula (7430678), Swetha Karka (7430675), Satyanarayana V. Nandury (7430681)   +3 more
core   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Polyethylenimine-based iron oxide nanoparticles enhance cisplatin toxicity in ovarian cancer cells in the presence of a static magnetic field

Frontiers in Oncology, 2023
BackgroundDrug resistance in cancer cells is a major concern in chemotherapy. Cisplatin (CIS) is one of the most effective chemotherapeutics for ovarian cancer. Here, we investigated an experimental approach to increase CIS cytotoxicity and overcome cell
Faranak Ashoori, Behnam Hajipour-Verdom, Mohammad Satari, Parviz Abdolmaleki   +3 more
doaj   +1 more source