Results 71 to 80 of about 35,820 (275)

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

All‐Solution‐Processed Top‐Emitting InP Quantum Dot Light‐Emitting Diode with Polyethylenimine Interfacial Layer

Advanced Electronic Materials
Recent studies on top‐emitting structure, which is designed to enhance the color purity and outcoupling efficiency of quantum‐dot light‐emitting diodes (QLEDs), employ commercially unviable methods owing to limited options for applying the hole injection
Youngwoo Jeon, Soobin Sim, Doyoon Shin, Wan Ki Bae, Hyunkoo Lee, Hyunho Lee   +5 more
doaj   +1 more source

Electrochemical Study of Enzymatic Glucose Sensors Biocatalyst: Thermal Degradation after Long-Term Storage

Chemosensors, 2018
The thermal degradation related to stability in long-term storage of a carbon nanotube-based biosensor has been investigated. The effect of storage temperature on detachment and denaturation of glucose oxidase (GOx) biocatalyst has been proved.
Marcelinus Christwardana, Domenico Frattini   +1 more
doaj   +1 more source

Carbon dioxide-modified polyethylenimine as a novel gene delivery vector and its in vitro validation

, 2017
In this work, the CO2-modified polyethylenimine, as a novel delivery vector, has been validated by combining with the plasmid DNA to form plasmid DNA/CO2-modified polyethylenimine complexes.
Hua Wu, Jing Quan, Fawei Shen, Hanbing Wu, Dongjie Shao, Quan J, Shao D, Wu H, Shen F   +8 more
core   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Performance of Pyridylthiourea‐Polyethylenimine Polyplex for siRNA‐Mediated Liver Cancer Therapy in Cell Monolayer, Spheroid, and Tumor Xenograft Models

Global Challenges, 2017
Medical application of siRNAs relies on methods for delivering nucleic acids into the cytosol. Synthetic carriers, which assemble with nucleic acids into delivery systems, show promises for cancer therapy but efficiency remains to be improved.
Jean Baptiste Gossart, Etienne Pascal, Florent Meyer, Emilie Heuillard, Mathieu Gonçalves, Francine Gossé, Eric Robinet, Benoît Frisch, Cendrine Seguin, Guy Zuber   +9 more
doaj   +1 more source

Polyethylenimine-Modified Graphene Oxide as a Novel Antibacterial Agent and Its Synergistic Effect with Daptomycin for Methicillin-Resistant Staphylococcus aureus

, 2018
An aqueous dispersion of polyethylenimine-modified graphene oxide (PEI-GO) was prepared via a one-step synthesis through an epoxy ring-opening reaction. PEI-GO exhibited bacterial growth inhibition activity on methicillin-resistant Staphylococcus aureus (
Zetan Fan (1835437), Shu Ping Lau (1423771), Kathy Hiu Laam Po (5100104), Sheng Chen (21971), Ka Kit Wong (5100101)   +4 more
core   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Investigation of the Adsorption of Dioleoyl-L-α-phosphatidic Acid Mono- and Bilayers from Vesicle Solution onto Polyethylenimine-Covered Substrates [PDF]

, 1996
The formation of monolayers and bilayers of dioleoyl-L-α-phosphatidic acid from solutions of small unilamellar vesicles onto polyethylenimine-treated substrates was investigated by means of small angle X-ray scattering and X-ray photoelectron ...
Sohling, Ulrich, Schouten, AJ, Schouten, Arend Jan, Sohling, U, Arend Jan Schouten, Ulrich Sohling   +5 more
core   +1 more source