Discovery of the first dual GSK3 beta inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease [PDF]
, 2017 The formation of neurofibrillary tangles (NFTs), oxidative stress and neuroinflammation have emerged as key targets for the treatment of Alzheimer’s disease (AD), the most prevalent neurodegenerative disorder.
Buendia, I +13 more
core
An overview of synthesis and biological activities of 2-pyridone derivatives over the last decade
Discover Applied Sciences2-Pyridone frameworks are a pervasive member of the N-heterocyclic family of both chemical and therapeutic interest. 2-Pyridones and their bridged analogues have wide occurrences in nature and the presence of both aromatic and amide groups in the ...
Lopamudra Das, Tista Sengupta
doaj +1 more source
The polyfunctionality of 'still' expressions
Expressions from the semasiological domain of phasal polarity (ʻstillʼ, ʻalreadyʼ, etc.) tend to be highly polyfunctional, with their various uses often extending into a wide range of other linguistic domains, both time-related and non-temporal. Yet these patterns have hitherto been investigated mostly for individual languages or smaller groups.
openaire +1 more source
Generation and validation of a novel multitarget small molecule in glioblastoma
Cell Death and DiseaseThe development of multitarget small molecules (MSMs) has emerged as a powerful strategy for the treatment of multifactorial diseases such as cancer. Glioblastoma is the most prevalent and malignant primary brain tumor in adults, which is characterized ...
Aizpea Artetxe-Zurutuza +16 more
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Polifunkcionalizált alifás és heterociklusos vegyületek új, alfa-azidoketonokból kiinduló szintézismódszereinek kifejlesztése = Development of new methodologies for the synthesis of polyfunctionalized aliphatic and heterocyclic compounds from alpha-azidoketones [PDF]
, 2008 További szintetikus bizonyítékokkal támasztottuk alá az alfa-azido-ketonokból nyerhető karbanionok és imid anionok alkalmazhatóságát több funkciós csoportot tartalmazó szintetikus építőkövek és különböző heterociklusos vegyületek előállítására.
Jekö, József +3 more
core
The development of imin-based tandem Michael-Mannich cyclocondensation through a single-electron transfer (SET)/energy transfer (EnT) pathway in the use of methylene blue (MB+) as a photo-redox catalyst. [PDF]
RSC Adv, 2022 Mohamadpour F.
europepmc +1 more source
Ylidic polyfunctionalized compounds with a diazinium skeleton
ARKIVOC, 2002 Maria C. Caprosu +4 more
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The polyfunctionality of which in Övdalian
, 2015 The Övdalian wh-word ukin has a variety of syntactic uses, spanning from the canonical use as personal pronoun (‘who’) to predicative property querying item (‘what … like’) and polarity item introducing both main and embedded clauses. In this paper the various uses will be described and discussed, and it will be argued that the polyfunctionality of ...
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Creating unimolecular multivalent diversity in protein conjugates via the Passerini multicomponent bioconjugation with isocyanoproteins. [PDF]
Commun ChemHumpierre AR +11 more
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