Results 91 to 100 of about 112,263 (200)
Phenome-wide and genome-wide analyses of quality of life in schizophrenia – ERRATUM
BJPsych Open, 2021 Raha Pazoki +6 more
doaj +1 more source
Characteristics of published polygenic risk scores.
Characteristics of published polygenic risk scores.
Zhengming Chen (385056) +6 more
core +1 more source
Editorial: Current advances in genetic dementia and aging
Frontiers in Aging Neuroscience, 2022 Yuzhen Xu +5 more
doaj +1 more source
Admixture-informed polygenic risk reporting using the ePRS framework
Nature CommunicationsPolygenic risk score values vary with genetic ancestry due to differences in population-specific allele frequencies and linkage disequilibrium patterns. We present a framework to calibrate polygenic risk scores based on ancestral makeup.
Yu-Jyun Huang +32 more
doaj +1 more source
A pre-train and fine-tune framework for adaptive boosting of pre-trained polygenic risk scores
Nature CommunicationsPolygenic risk scores are widely used for predicting genetic risk across complex diseases and traits, and several pre-trained models have been developed.
Jie Hu +18 more
doaj +1 more source
Leveraging haplotype information in heritability estimation and polygenic prediction
Nature CommunicationsPolygenic prediction has yet to make a major clinical breakthrough in precision medicine and psychiatry, where the application of polygenic risk scores is expected to improve clinical decision-making.
Jonas Meisner +2 more
doaj +1 more source
Prediction of Polygenic Risks by Screening Thousands of Polygenic Scores
Abstract Rationale A polygenic score (PGS) summarizes a person’s genetic information in a single number for a trait, and its utility in genomic medicine is well-recognized. Although PGS models have been generated for many traits, they are not broadly available for certain traits ...
Wei-Min Chen +4 more
openaire +1 more source
Calculating polygenic scores with the Polygenic Score Catalog Calculator
Polygenic scores (PGS) are a measurement which represents genetic predisposition for a heritable trait or phenotype by aggregating the effects of hundreds-to-millions of genetic variants into a single number. The PGS Catalog is the world’s largest FAIR (finable, accessible, interoperable, and reusable) repository of PGS along with the relevant metadata
Samuel Lambert, Benjamin Wingfield
openaire +1 more source
Atrial Fibrillation in Valvular Heart Disease: Assessing the Impact of Genetics in the UK Biobank. [PDF]
JACC AdvCristin L +6 more
europepmc +1 more source