Results 81 to 90 of about 112,263 (200)

Clines in polygenic traits

Genetical Research, 1999
This article outlines theoretical models of clines in additive polygenic traits, which are maintained by stabilizing selection towards a spatially varying optimum. Clines in the trait mean can be accurately predicted, given knowledge of the genetic variance.
openaire   +2 more sources

Polygenic selection on educational attainment

, 2016
The genetic variants identified by two large GWAS of educational attainment were used to test a polygenic selection model.Average frequencies of alleles with positive (Beta) effect on the phenotype (polygenic scores) were compared across populations and ...
Davide Piffer (630526)
core   +1 more source

Personality and polygenic vulnerability for psychopathology

, 2019
Assessing associations between Big 5 personality traits and polygenic vulnerability for ...
Danielle Boisvert, Nicholas Kavish, Jaime Anderson, Brian Boutwell   +3 more
core   +1 more source

Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function.

PLoS ONE, 2018
Neurodegenerative disorders are associated with impaired cognitive function and worse physical health outcomes. This study aims to test whether polygenic risk for Alzheimer's disease, Amyotrophic Lateral Sclerosis (ALS), or frontotemporal dementia (FTD ...
Saskia P Hagenaars, Ratko Radaković, Christopher Crockford, Chloe Fawns-Ritchie, International FTD-Genomics Consortium (IFGC), Sarah E Harris, Catharine R Gale, Ian J Deary   +7 more
doaj   +1 more source

Δlpp mutant E. coli reduces lipid content in Caenorhabditis elegans via phosphatidylglycerol-mediated inhibition of fatty acid biosynthesis

mSystems
Although the gut microbiota is known to influence host metabolism, how specific bacterial genetic mutations modulate lipid metabolism remains unclear.
Dianshuang Zhou, Liwei Tang, Mengdie Ni, Wen Yang, Xiangming Wang, Ying Li, Zuobin Zhu   +6 more
doaj   +1 more source

Prenatal PM

Ecotoxicology and Environmental Safety
Prenatal exposure to fine particulate matter (PM 2.5 ) is a critical risk factor for neurodevelopmental impairment in male offspring; however, its effects on synaptic development and the underlying transcription factor (TF) regulatory networks remain ...
Xueyi Cai, Yuetong Liu, Jiayi Wang, Xinyi Pan, Mingyu Wu, Nannan Chen, Xinru Jiang, Senlin Xue, Yudong Zhang, Wei Yan   +9 more
doaj   +1 more source

Longitudinal profiles, predictors and brain maintenance of Betula Superagers

Translational Neuroscience
Episodic memory is typically declining in older age but some Superagers have high performance levels. A superager level of performance may be preceded by different trajectories.
Nyberg Lars, Lundquist Anders
doaj   +1 more source

Interplay between lifestyle factors and polygenic risk for incident coronary heart disease in a large multiethnic cohort

International Journal of Cardiology. Cardiovascular Risk and Prevention
Introduction: The objective of this study was to examine the interplay of polygenic risk and individual lifestyle factors (and a composite score of lifestyle) as antecedents of CHD in a large multiethnic cohort.
Carlos Iribarren, Meng Lu, Martha Gulati, Nathan D. Wong, Roberto Elosua, Jamal S. Rana   +5 more
doaj   +1 more source

Patient Perspectives on Personalized Risk Communication Using Polygenic Risk Scores to Inform Colorectal Cancer Screening Decisions

AJPM Focus
Introduction: Colorectal cancer is increasingly diagnosed in people aged
Shauna R. Goldberg, MPH, Linda K. Ko, PhD, Li Hsu, PhD, Hang Yin, MS, Charles Kooperberg, PhD, Ulrike Peters, PhD, MPH, Andrea N. Burnett-Hartman, PhD, MPH   +6 more
doaj   +1 more source

Epistasis in Polygenic Traits and the Evolution of Genetic Architecture under Stabilizing Selection

, 2003
EPISTASIS IN POLYGENIC TRAITS AND THE EVOLUTION OF GENETIC ARCHITECTURE UNDER STABILIZING SELECTION Epistasis in Polygenic Traits and the Evolution of Genetic Architecture under Stabilizing Selection (161) (-
Hermisson, Joachim Thomas F. Hansen Gunter P. Wagner
core   +2 more sources