Results 51 to 60 of about 112,263 (200)

Headaches and polygenic scores [PDF]

Neurology Genetics, 2019
Polygenic risk scores are en vogue. This ubiquitous statistic quantifies disease liability for an individual by aggregating risk contributions from a large number of genetic variants into a single score. Recent publications have argued that risk models currently used in clinical settings for coronary artery disease can be improved by including ...
Vilhjálmsson, Bjarni J., Privé, Florian   +1 more
openaire   +2 more sources

Validation of GenProb‐T1D and its clinical utility for differentiating types of diabetes in a biobank from a US healthcare system

Journal of Diabetes Investigation
Atypical diabetes with overlapping clinical features of type 1 (T1D) and type 2 (T2D) is common and challenging diagnostically and for implementing effective treatment. Here, we validate a recently reported genetic probability of type 1 diabetes (GenProb‐
Liana K. Billings, Zhuqing Shi, Ashley J. Mulford, Jun Wei, Huy Tran, Annabelle Ashworth, S. Lilly Zheng, Henry M. Dunnenberger, Peter J. Hulick, Alan R. Sanders, Jianfeng Xu   +10 more
doaj   +1 more source

Common polygenic variation contributes to risk of migraine in the Norfolk Island population [PDF]

, 2015
Migraine has been defined as a common disabling primary headache disorder. Epidemiology studies have provided with the undeniable evidence of genetic components as active players in the development of the disease under a polygenic model in which
Benton, Miles C., Goring, Harald H. H., Curran, Joanne E, Curran, Joanne E., Carless, Melanie A., Göring, Harald H., Rodriguez-Acevedo, A. J., Griffiths, L. R., Ferreira, Manuel A., Rodriguez-Acevedo, Astrid J., Lea, R. A., Griffiths, Lyn R., Blangero, John, Lea, Rod A., Ferreira, M. A.   +14 more
core   +1 more source

Detailed assessment of rare and common TERT variation in a family with a telomere biology disorder

HGG Advances
Summary: Telomere biology disorders (TBDs) are caused by rare pathogenic variants in telomere maintenance genes and often present with variable penetrance of multi-organ system manifestations.
Logan P. Zeigler, Oscar Florez-Vargas, Burak Altintas, Marena R. Niewisch, Weiyin Zhou, Neelam Giri, Maryam Rafati, Michael Poeschla, Vijay G. Sankaran, Tsung-Po Lai, Abraham Aviv, Kristine Jones, Wen Luo, Jia Liu, Lisa J. McReynolds, Tianna Zhao, Ludmila Prokunina-Olsson, Sharon A. Savage   +17 more
doaj   +1 more source

Interpreting polygenic scores, polygenic adaptation, and human phenotypic differences [PDF]

Evolution, Medicine, and Public Health, 2018
Abstract Recent analyses of polygenic scores have opened new discussions concerning the genetic basis and evolutionary significance of differences among populations in distributions of phenotypes. Here, we highlight limitations in research on polygenic scores, polygenic adaptation and population differences.
Rosenberg, Noah A, Edge, Michael D, Pritchard, Jonathan K, Feldman, Marcus W   +3 more
openaire   +2 more sources

Genetic variation in gut microbe as a key regulator of host social behavior in C. elegans

Gut Microbes
Gut microbiota have been shown to influence the social behaviors of their hosts, while variations in host genetics can affect the composition of the microbiome.
Ying Li, Ruijie Bai, Yao Zhu, Peng Shi, Tao Wang, Dianshuang Zhou, Jianteng Zhou, Tao Zhu, Xinrong Zhang, Rongrong Gu, Xiaoyue Ding, Hao Chen, Xiangming Wang, Zuobin Zhu   +13 more
doaj   +1 more source

Genes and molecules related to obesity and lifestyle-related disease and exercise

Journal of Physical Fitness and Sports Medicine, 2013
In 2006, Rankinen et al. reported 127 candidate obesity-related genes, and since then more have been identified (http://www.genome.gov/gwastudies/). A lot of mutations in more than 7 genes, especially in the MC4-R gene, were reported as monogenic obesity
Masaki Kimura
doaj   +1 more source

Polygenic Risk for Externalizing Disorders [PDF]

, 2015
In this project, we aimed to bring large-scale gene identification findings into a developmental psychopathology framework. Using a family-based sample, we tested whether polygenic scores for externalizing disorders-based on single nucleotide ...
Hesselbrock, Michie, Salvatore, Jessica E, Kuperman, Samuel, Dick, Danielle M, Aliev, Fazil, Edenberg, Howard J, Agrawal, Arpana, Hesselbrock, Victor, Bucholz, Kathleen, Bauer, Lance, Schuckit, Marc A, Foroud, Tatiana M, Kramer, John R   +12 more
core   +1 more source

Microbial genetic composition regulates host social behavior

Gut Microbes
The co-evolutionary relationship between gut microbiota and their hosts is influenced by microbial genetic variation, which enables adaptation to host environmental changes, modifies metabolic processes, and refines host–microbiota interactions ...
Ruijie Bai, Tao Wang, Rongrong Gu, Yawei Cai, Juntao Chen, Wen Cai, Dianshuang Zhou, Ying Li, Jixun Luo, Xiangming Wang, Zuobin Zhu   +10 more
doaj   +1 more source

Selection and Polygenic Characters [PDF]

Proceedings of the National Academy of Sciences, 1970
A mathematical model is developed which describes the effect of selection on polygenic or continuously varying phenotypic characters. For the simplest case the standard deviation of a phenotypic character in a population cannot be greater than √2β where β is the expected deviation of the offspring from the average of the parents' types.
openaire   +2 more sources