Results 31 to 40 of about 112,263 (200)

Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans

Frontiers in Immunology, 2022
Most B cells produced in the bone marrow have some level of autoreactivity. Despite efforts of central tolerance to eliminate these cells, many escape to periphery, where in healthy individuals, they are rendered functionally non-responsive to ...
Isaac T. W. Harley, Isaac T. W. Harley, Isaac T. W. Harley, Kristen Allison, Kristen Allison, R. Hal Scofield, R. Hal Scofield, R. Hal Scofield   +7 more
doaj   +1 more source

Polygenic sex determination [PDF]

Current Biology, 2013
What is sex determination? Sex determination is the mechanism by which sexual organisms direct gonad development towards distinct but reproductively compatible outcomes. Molecular signaling cascades in the developing gonad provide instructions to the tissue to develop as male or female (or in some cases hermaphrodite), and these signals can be ...
Moore, Emily C., Roberts, Reade B.
openaire   +2 more sources

GWAS reveals novel loci and identifies a pentatricopeptide repeat-containing protein (CsPPR) that improves low temperature germination in cucumber

Frontiers in Plant Science, 2023
Low temperatures (LTs) negatively affect the percentage and rate of cucumber (Cucumis sativus L.) seed germination, which has deleterious effects on yield.
Caixia Li, Shaoyun Dong, Diane M. Beckles, Xiaoping Liu, Jiantao Guan, Xingfang Gu, Han Miao, Shengping Zhang   +7 more
doaj   +1 more source

Assessing the performance of genetic risk score for stratifying risk of post-sepsis cardiovascular complications

Frontiers in Cardiovascular Medicine, 2023
BackgroundPatients with sepsis are at increased risk for cardiovascular complications, including myocardial infarction (MI), ischemic stroke (IS), and venous thromboembolism (VTE).
Brian McElligott, Zhuqing Shi, Andrew S. Rifkin, Jun Wei, S. Lilly Zheng, Brian T. Helfand, Brian T. Helfand, Brian T. Helfand, Jonathan S. H. Woo, Jianfeng Xu, Jianfeng Xu, Jianfeng Xu, Jianfeng Xu   +12 more
doaj   +1 more source

Genomic saturation mutagenesis and polygenic analysis identify novel yeast genes affecting ethyl acetate production, a non-selectable polygenic trait

, 2016
Isolation of mutants in populations of microorganisms has been a valuable tool in experimental genetics for decades. The main disadvantage, however, is the inability of isolating mutants in non-selectable polygenic traits.
Ben Souffriau, Johan M. Thevelein, Foulquié Moreno, Maria R., Abt, Tom den, Tom Den Abt, Jorge Duitama, Duitama, Jorge, Thevelein, Johan, Souffriau, Ben, Maria R. Foulquié-Moreno   +9 more
core   +1 more source

Polygenic Risk Scores in Alzheimer's Disease: Current Applications and Future Directions

Frontiers in Digital Health, 2020
Genome-wide association studies have identified nearly 40 genome-wide significant single nucleotide polymorphisms (SNPs) which are associated with Alzheimer's Disease (AD).
Emily Baker, Valentina Escott-Price, Valentina Escott-Price   +2 more
doaj   +1 more source

A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin [PDF]

Molecular Genetics & Genomic Medicine, 2020
AbstractBackgroundSevere hypercholesterolemia (HC, LDL‐C > 4.9 mmol/L) affects over 30 million people worldwide. In this study, we validated a new polygenic risk score (PRS) for LDL‐C.MethodsSummary statistics from the Global Lipid Genome Consortium and genotype data from two large populations were used.ResultsA 36‐SNP PRS was generated using data ...
Luis G. Leal, Clive Hoggart, Marjo‐Riitta Jarvelin, Karl‐Heinz Herzig, Michael J. E. Sternberg, Alessia David   +5 more
openaire   +5 more sources

Serum MGP and ECP are commonly elevated in first-onset and recurrent ischemic stroke: a two-phase DIA proteomic study in a Chinese cold-region cohort

Frontiers in Neurology
BackgroundIschemic stroke (IS) has a high recurrence rate, yet effective biomarkers for distinguishing first-onset from recurrent IS remain limited.
Ningning Wang, Zhengguang Guo, Ming Jin, Nan Wu, Zhi Zheng, Wei Sun, Zaihua Zhang, Changchun Qiu, Changchun Qiu, Keyong Zhang   +9 more
doaj   +1 more source

Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries. PTRS training code repository.

, 2021
This is a release for zenodo containing the PTRS training code for paper "Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries." (https://www.biorxiv.org/content/10.1101/2020.11.12 ...
Yanyu Liang
core   +1 more source

Microbial genetic screen identifies bacterial genes that compromise Caenorhabditis elegans reproductive fitness

mSystems
The mechanisms by which microbial genetic variation governs host reproductive fitness remain to be determined. Defining the causal relationship between specific microbial genes and host reproduction not only facilitates understanding of the microbe–host ...
Ziling Yang, Huigui Guo, Yudong Zhang, Xinzhou Jia, Yalun Wu, Tao Zhu, Ying Li, Jinyue Wang, Dianshuang Zhou, Zuobin Zhu   +9 more
doaj   +1 more source