Results 11 to 20 of about 112,263 (200)

Polygenic Epidemiology [PDF]

Genetic Epidemiology, 2016
ABSTRACTMuch of the genetic basis of complex traits is present on current genotyping products, but the individual variants that affect the traits have largely not been identified. Several traditional problems in genetic epidemiology have recently been addressed by assuming a polygenic basis for disease and treating it as a single entity. Here I briefly
Frank Dudbridge (102283)
core   +8 more sources

Polygenic diseases [PDF]

Journal of Education, Health and Sport
Background: Recent advances in molecular genetics have revolutionized our understanding of hereditary diseases, particularly polygenic (multifactorial) conditions. This comprehensive review examines the genetic basis of common polygenic diseases, including diabetes, preeclampsia, breast cancer, and factors influencing athletic performance.
Dolomatov, Sergey, Zukow, Walery, Zhukova, Anna, Smirnova, Svetlana   +3 more
core   +6 more sources

Polygenic scores, polygenic selection and spatial autocorrelation

, 2017
Tests of polygenic selection are performed using GWAS hits and an empirical simulation with random ...
Davide Piffer (630526)
openaire   +2 more sources

Potential use of clinical polygenic risk scores in psychiatry – ethical implications and communicating high polygenic risk [PDF]

Philosophy, Ethics, and Humanities in Medicine, 2019
Psychiatric disorders present distinct clinical challenges which are partly attributable to their multifactorial aetiology and the absence of laboratory tests that can be used to confirm diagnosis or predict risk.
A. C. Palk, S. Dalvie, J. de Vries, A. R. Martin, D. J. Stein   +4 more
doaj   +2 more sources

Generalisation of genomic findings and applications of polygenic risk scores [PDF]

, 2023
Polygenic Risk Scores (PRS) (also known as polygenic scores, genetic risk scores or polygenic indexes) capture genetic contributions of a multitude of markers that characterise complex traits.
Corpas, Manuel, Fatumo, Segun
core   +4 more sources

The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores [PDF]

, 2022
The process of identifying suitable genome-wide association (GWA) studies and formatting the data to calculate multiple polygenic risk scores on a single genome can be laborious.
Veitch, D, González, H, Ward, C, Kormos, A, Jagust, W, Moore, S, Mathis, C, Barnes, L, Potter, W, Hergesheimer, L, Gessert, D, Taylor-Reinwald, L, Harvey, D, Householder, E, Silverberg, N, Gunter, J, Chen, SR, Yushkevich, PA, Raman, R, Sacrey, DT, Toga, AW, Jin, C, Zimmerman, C, Landau, S, Adegoke, O, Masterman, D, Jackson, J, DeCarli, C, Masliah, E, Schwarz, C, Aisen, P, Shaw, LM, Smith, S, Senjem, M, Fox, NC, Jack, CR, Choe, M, Fletcher, E, Thomopoulos, SI, Perrin, R, Borowski, B, Weiner, MW, Beckett, L, Jahanshad, N, Cairns, NJ, Korecka, M, Franklin, E, Koeppe, RA, Fleisher, A, Hsiao, JK, Walter, S, Mahboubi, P, Tojanowki, JQ, Conti, C, Khachaturian, Z, Vemuri, P, Green, RC, Coker, G, Figurski, M, Neuhaus, J, Pizzola, J, Perrin, RJ, Forghanian-Arani, A, Bernhardt, H, Clanton, T, Okonkwo, O, Jimenez, G, Jones, D, Das, S, Sloan, B, Petersen, R, Nosheny, R, Rafii, M, Shaffer, E, Ryan, L, Kantarci, K, Trojanowki, JQ, Malone, I, Nir, TM, Tosun-Turgut, D, Reiman, EM, Chen, K, Crawford, K, Knaack, A, Donohue, M, Bernard, M, Salazar, J, Ashford, M, Ho, C, Monine, T, Miller, G, Fockler, J, Cabrera, Y, Saykin, AJ, Carrillo, M, Thompson, P, Morris, JC, Flenniken, D, Reid, R, Cloward, Matthew E., Ebbert, Mark T. W., Kauwe, John S. K., Mark T. W. Ebbert, Justin B. Miller, Matthew E. Cloward, Dayton, Louisa, Vance, Elizabeth L., The Alzheimer’s Disease Neuroimaging Initiative, Page, Madeline L., Ed Ringger, Ringger, Ed, Elizabeth L. Vance, John S. K. Kauwe, Miller, Justin B., Madeline L. Page, Alzheimer’s Disease Neuroimaging Initiative, Louisa Dayton   +116 more
core   +5 more sources

A Polygenic Approach to the Study of Polygenic Diseases [PDF]

Acta Naturae, 2012
Polygenic diseases are caused by the joint contribution of a number of independently acting or interacting polymorphic genes; the individual contribution of each gene may be small or even unnoticeable. The carriage of certain combinations of genes can determine the occurrence of clinically heterogeneous forms of the disease and treatment efficacy. This
Lvovs, D., Favorova, O., Favorov, A.
openaire   +3 more sources

Schizophrenia polygenic risk score influence on white matter microstructure [PDF]

, 2020
Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations ...
Sukhi Shergill, Elvira Bramon, Colm McDonald, Beatriz Simões, Timothea Toulopoulou, Robin Murray, Hugo Ferreira, Evangelos Vassos, Diana Prata, Fergus Kane, Sridevi Kalidindi   +10 more
core   +3 more sources

Polygenic scores in cancer

Nature Reviews Cancer, 2023
Since the publication of the first genome-wide association study for cancer in 2007, thousands of common alleles that are associated with the risk of cancer have been identified. The relative risk associated with individual variants is small and of limited clinical significance.
Yang, Xin, Kar, Siddhartha, Antoniou, Antonis C, Pharoah, Paul DP   +3 more
openaire   +2 more sources

Polygenes and polymorphism

Molecular and General Genetics MGG, 1967
Uploaded by Plazi for TaxoDros. We do not have abstracts.
P A, Parsons, S M, Hosgood, B T, Lee
openaire   +3 more sources