Results 1 to 10 of about 613,789 (384)

Polygenic Risk Score Prediction for Endometriosis [PDF]

Frontiers in Reproductive Health, 2021
Endometriosis is a major health care challenge because many young women with endometriosis go undetected for an extended period, which may lead to pain sensitization.
Kirstine Kloeve-Mogensen, Kirstine Kloeve-Mogensen, Palle Duun Rohde, Palle Duun Rohde, Simone Twisttmann, Marianne Nygaard, Kristina Magaard Koldby, Rudi Steffensen, Christian Møller Dahl, Dorte Rytter, Michael Toft Overgaard, Axel Forman, Lene Christiansen, Lene Christiansen, Mette Nyegaard, Mette Nyegaard   +15 more
doaj   +11 more sources

Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog [PDF]

BMJ Medicine, 2023
Objective To clarify the performance of polygenic risk scores in population screening, individual risk prediction, and population risk stratification.Design Secondary analysis of data in the Polygenic Score Catalog.Setting Polygenic Score Catalog, April ...
Harry Hemingway, Riyaz Patel, Joan K Morris, Aroon D Hingorani, Reecha Sofat, Claudia Langenberg, Nicholas J Wald, Valerie Kuan, Chris Finan, Jasmine Gratton, A Floriaan Schmidt   +10 more
doaj   +4 more sources

PRSice: Polygenic Risk Score software [PDF]

Bioinformatics, 2014
Summary: A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study.
Jack Euesden, Cathryn M. Lewis, Paul F. O’Reilly   +2 more
semanticscholar   +8 more sources

Integration of risk factor polygenic risk score with disease polygenic risk score for disease prediction [PDF]

Communications Biology
Polygenic risk score (PRS) is useful for capturing an individual’s genetic susceptibility. However, previous studies have not fully exploited the potential of the risk factor PRS (RFPRS) for disease prediction.
Hyein Jung, Hae-Un Jung, Eun Ju Baek, Shin Young Kwon, Ji-One Kang, Ji Eun Lim, Bermseok Oh   +6 more
doaj   +4 more sources

Association Between Polygenic Risk Score and Risk of Myopia [PDF]

JAMA Ophthalmology, 2019
Myopia is a leading cause of untreatable visual impairment and is increasing in prevalence worldwide. Interventions for slowing childhood myopia progression have shown success in randomized clinical trials; hence, there is a need to identify which children would benefit most from treatment intervention.To examine whether genetic information alone can ...
Neema Ghorbani‐Mojarrad, Denis Plotnikov, Cathy Williams, Jeremy A. Guggenheim   +3 more
core   +9 more sources

Twelve Variants Polygenic Score for Low‐Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background A significant proportion of individuals clinically diagnosed with familial hypercholesterolemia (FH), but without any disease‐causing mutation, are likely to have polygenic hypercholesterolemia.
Elena Olmastroni, Marta Gazzotti, Marcello Arca, Maurizio Averna, Angela Pirillo, Alberico Luigi Catapano, Manuela Casula   +6 more
doaj   +6 more sources

The Correlation between Inflammatory Biomarkers and Polygenic Risk Score in Alzheimer’s Disease [PDF]

, 2016
Plasma biomarkers to aid the early diagnosis of Alzheimer’s disease (AD) or to monitor disease progression have long been sought and continue to be widely studied.
Angharad R. Morgan, Samuel Touchard, Caroline O’Hagan, Rebecca Sims, Elisa Majounie, Valentina Escott‐Price, Lesley Jones, Julie Williams, B. Paul Morgan   +8 more
openalex   +4 more sources

A polygenic risk score for multiple myeloma risk prediction [PDF]

European Journal of Human Genetics, 2021
There is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk loci that contribute to the genetic susceptibility of MM, but have low ...
Abildgaard N., Andersen N. F., Andersen V., Avet-Loiseau H., Beider K., Buda G., Butrym A., Campa D., Canzian F., Druzd-Sitek A., Dudzinski M., Dumontet C., Gemignani F., Jamroziak K., Jurczyszyn A., Kadar K., Kruszewski M., Lesueur F., Macauda A., Marques H., Mazur G., Minvielle S., Nagler A., Orciuolo E., Pelosini M., Petrini M., Piredda C., Razny M., Reis R. M., Rymko M., Sainz J., Subocz E., Suska A., Tomczak W., Vangsted A. J., Varkonyi J., Vogel U., Watek M., Zaucha J. M., Zawirska D.   +39 more
core   +18 more sources

A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood

Nature Communications, 2022
Polygenic risk scores have potential to predict an individual’s risk of disease based on genetic markers. Here, the authors develop a polygenic risk score for hypertension and test it in a multi-ethnic cohort, finding that the score is associated with ...
Nuzulul Kurniansyah, Matthew O. Goodman, Tanika N. Kelly, Tali Elfassy, Kerri L. Wiggins, Joshua C. Bis, Xiuqing Guo, Walter Palmas, Kent D. Taylor, Henry J. Lin, Jeffrey Haessler, Yan Gao, Daichi Shimbo, Jennifer A. Smith, Bing Yu, Elena V. Feofanova, Roelof A. J. Smit, Zhe Wang, Shih-Jen Hwang, Simin Liu, Sylvia Wassertheil-Smoller, JoAnn E. Manson, Donald M. Lloyd-Jones, Stephen S. Rich, Ruth J. F. Loos, Susan Redline, Adolfo Correa, Charles Kooperberg, Myriam Fornage, Robert C. Kaplan, Bruce M. Psaty, Jerome I. Rotter, Donna K. Arnett, Alanna C. Morrison, Nora Franceschini, Daniel Levy, the NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, Tamar Sofer   +37 more
doaj   +2 more sources

PRSet: Pathway-based polygenic risk score analyses and software.

PLoS Genetics, 2023
Polygenic risk scores (PRSs) have been among the leading advances in biomedicine in recent years. As a proxy of genetic liability, PRSs are utilised across multiple fields and applications.
Shing Wan Choi, Judit García-González, Yunfeng Ruan, Hei Man Wu, Christian Porras, Jessica Johnson, Bipolar Disorder Working group of the Psychiatric Genomics Consortium, Clive J Hoggart, Paul F O'Reilly   +8 more
doaj   +2 more sources