Development of risk prediction models for depression combining genetic and early life risk factors [PDF]
Frontiers in Neuroscience, 2023 BackgroundBoth genetic and early life risk factors play important roles in the pathogenesis and progression of adult depression. However, the interplay between these risk factors and their added value to risk prediction models have not been fully ...
Tianyuan Lu +6 more
doaj +3 more sources
Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease
BMC Medicine, 2022 Background The value of polygenic risk scores (PRSs) towards improving guideline-recommended clinical risk models for coronary artery disease (CAD) prediction is controversial.
Austin King +4 more
doaj +2 more sources
Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study [PDF]
Breast Cancer Research, 2021 Background Advancements in cancer therapeutics have resulted in increases in cancer-related survival; however, there is a growing clinical dilemma. The current balancing of survival benefits and future cardiotoxic harms of oncotherapies has resulted in ...
Lathan Liou +7 more
doaj +4 more sources
Polygenic risk score: use in migraine research [PDF]
The Journal of Headache and Pain, 2018 Background The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10− 8) due to multiple testing.
Mona Ameri Chalmer +3 more
doaj +6 more sources
GenoRisk: A polygenic risk score for Alzheimer's disease [PDF]
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021 Introduction Recent clinical trials are considering inclusion of more than just apolipoprotein E (APOE) ε4 genotype as a way of reducing variability in analysis of outcomes.
Samuel P. Dickson +10 more
doaj +3 more sources
Polygenic Risk Score and Risk Factors for Gestational Diabetes
Journal of Personalized Medicine, 2022 Gestational diabetes mellitus (GDM) is a common complication of pregnancy that adversely affects maternal and offspring health. A variety of risk factors, such as BMI and age, have been associated with increased risks of gestational diabetes. However, in
M. Perišić +5 more
semanticscholar +4 more sources
Deep-learning prediction of cardiovascular outcomes from routine retinal images in individuals with type 2 diabetes [PDF]
Cardiovascular DiabetologyBackground Prior studies have demonstrated an association between retinal vascular features and cardiovascular disease (CVD), however most studies have only evaluated a few simple parameters at a time.
Mohammad Ghouse Syed +8 more
doaj +3 more sources
Schizophrenia polygenic risk score in psychosis proneness [PDF]
European Archives of Psychiatry and Clinical Neuroscience, 2023 Schizophrenia (SZ) is a complex disorder with a highly polygenic inheritance. It can be conceived as the extreme expression of a continuum of traits that are present in the general population often broadly referred to as schizotypy.
Barrantes-Vidal, Neus +7 more
core +4 more sources
Performance of polygenic scores for predicting phobic anxiety. [PDF]
PLoS ONE, 2013 Anxiety disorders are common, with a lifetime prevalence of 20% in the U.S., and are responsible for substantial burdens of disability, missed work days and health care utilization.
Stefan Walter +9 more
doaj +11 more sources
The polygenic risk for bipolar disorder influences brain regional function relating to visual and default state processing of emotional information [PDF]
NeuroImage: Clinical, 2016 Genome-wise association studies have identified a number of common single-nucleotide polymorphisms (SNPs), each of small effect, associated with risk to bipolar disorder (BD).
Danai Dima +3 more
doaj +4 more sources