Results 21 to 30 of about 613,789 (384)

Polygenic risk score, healthy lifestyles, and risk of incident depression

Translational Psychiatry, 2021
Genetic factors increase the risk of depression, but the extent to which this can be offset by modifiable lifestyle factors is unknown. We investigated whether a combination of healthy lifestyles is associated with lower risk of depression regardless of ...
Zhi Cao, Hongxi Yang, Yixuan Ye, Yuan Zhang, Shu Li, Hongyu Zhao, Yaogang Wang   +6 more
doaj   +2 more sources

Using LDpred2 to adapt polygenic risk score techniques for methylation score creation [PDF]

BMC Research Notes
Objective This study sought to determine if the R package LDpred2, designed for polygenic risk score creation for genome-wide association studies using summary statistics, could be adapted for deriving DNA methylation scores from methylome-wide ...
Kristoffer Sandås, Leticia Spindola, Solveig Løkhammer, Anne-Kristin Stavrum, Ole Andreassen, Markos Tesfaye, Stéphanie Le Hellard   +6 more
doaj   +2 more sources

Stacked neural network for predicting polygenic risk score [PDF]

Scientific Reports
In recent years, the utility of polygenic risk scores (PRS) in forecasting disease susceptibility from genome-wide association studies (GWAS) results has been widely recognised.
Sun bin Kim, Joon Ho Kang, MyeongJae Cheon, Dong Jun Kim, Byung-Chul Lee   +4 more
doaj   +2 more sources

Psychosis Endophenotypes: A Gene-Set-Specific Polygenic Risk Score Analysis [PDF]

, 2023
BACKGROUND AND HYPOTHESIS: Endophenotypes can help to bridge the gap between psychosis and its genetic predispositions, but their underlying mechanisms remain largely unknown.
Alizadeh, Behrooz Z, Arranz, Maria J, Austin-Zimmerman, Isabelle, Bass, Nick, Bender, Stephan, Bhat, Anjali, Bramon, Elvira, Cahn, Wiepke, Crespo-Facorro, Benedicto, de Haan, Lieuwe, Di Forti, Marta, Genetic Risk and Outcome of Psychosis (GROUP) Study, Giegling, Ina, Gkofa, Vasiliki, Hall, Jeremy, Hall, Mei-Hua, Harju-Seppänen, Jasmine, Irizar, Haritz, Iyegbe, Conrad, Kahn, René S, Kravariti, Eugenia, Kuchenbaecker, Karoline, Lawrie, Stephen M, Lin, Kuang, Luykx, Jurjen J, Mata, Ignacio, McDonald, Colm, McIntosh, Andrew M, McQuillin, Andrew, Murray, Robin M, Pain, Oliver, Picchioni, Marco, Powell, John, Prata, Diana P, Psychosis Endophenotypes International Consortium (PEIC), Rujescu, Dan, Rutten, Bart PF, Shaikh, Madiha, Simons, Claudia JP, Stella Calafato, Maria, Thygesen, Johan H, Toulopoulou, Timothea, van Amelsvoort, Therese, van Haren, Neeltje, van Winkel, Ruud, Wang, Baihan, Weisbrod, Matthias, Zartaloudi, Eirini   +47 more
core   +9 more sources

Schizophrenia polygenic risk score and psychotic risk detection [PDF]

The Lancet Psychiatry, 2017
Michele Poletti, Eva Gebhardt, Andrea Raballo   +2 more
openalex   +5 more sources

Polygenic Risk Scores and Physical Activity [PDF]

Medicine & Science in Sports & Exercise, 2020
ABSTRACT Purpose Polygenic risk scores (PRS) summarize genome-wide genotype data into a single variable that produces an individual-level risk score for genetic liability. PRS has been used for prediction of chronic diseases and some risk factors. As PRS has been studied less for physical activity (PA), we constructed
Kujala, Urho M., Palviainen, Teemu, Pesonen, Paula, Waller, Katja, Sillanpää, Elina, Niemelä, Maisa, Kangas, Maarit, Vähä-Ypyä, Henri, Sievänen, Harri, Korpelainen, Raija, Jämsä, Timo, Männikkö, Minna, Kaprio, Jaakko   +13 more
openaire   +7 more sources

Polygenic Score Models for Alzheimer’s Disease: From Research to Clinical Applications

Frontiers in Neuroscience, 2021
The high prevalence of Alzheimer’s disease (AD) among the elderly population and its lack of effective treatments make this disease a critical threat to human health.
Xiaopu Zhou, Xiaopu Zhou, Xiaopu Zhou, Yolanda Y. T. Li, Amy K. Y. Fu, Amy K. Y. Fu, Amy K. Y. Fu, Nancy Y. Ip, Nancy Y. Ip, Nancy Y. Ip   +9 more
doaj   +1 more source

A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease

Nature Network Boston, 2023
A polygenic risk score for coronary artery disease developed using data from individuals of five different ancestries has increased accuracy across diverse populations.
A. Patel, Minxian Wang, Y. Ruan, S. Koyama, S. Clarke, Xiong Yang, C. Tcheandjieu, Saaket Agrawal, A. Fahed, P. Ellinor, P. Tsao, Yan V. Sun, Kelly Cho, P. Wilson, T. Assimes, D. V. van Heel, A. Butterworth, Krishna G. Aragam, P. Natarajan, A. Khera   +19 more
semanticscholar   +1 more source

Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists

Frontiers in Genetics, 2022
A polygenic risk score estimates the genetic risk of an individual for some disease or trait, calculated by aggregating the effect of many common variants associated with the condition.
Jennifer A. Collister, Xiaonan Liu, Lei Clifton   +2 more
doaj   +1 more source

Polygenic Risk Scores for Subtyping of Schizophrenia [PDF]

Schizophrenia Research and Treatment, 2020
Schizophrenia is a complex disorder with many comorbid conditions. In this study, we used polygenic risk scores (PRSs) from schizophrenia and comorbid traits to explore consistent cluster structure in schizophrenia patients. With 10 comorbid traits, we found a stable 4-cluster structure in two datasets (MGS and SSCCS).
Jingchun Chen, Travis Mize, Jain-Shing Wu, Elliot Hong, Vishwajit Nimgaonkar, Kenneth S. Kendler, Daniel Allen, Edwin Oh, Alison Netski, Xiangning Chen   +9 more
openaire   +4 more sources