Results 61 to 70 of about 65,839 (347)

Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics

Nature Communications, 2023
Polygenic risk scores are used to improve risk prediction for common diseases but typically have reduced accuracy for individuals of non-European ancestry.
Jiacheng Miao, Hanmin Guo, Gefei Song, Zijie Zhao, Lin Hou, Qiongshi Lu   +5 more
doaj   +1 more source

Genetic susceptibility loci for cardiovascular disease and their impact on atherosclerotic plaques [PDF]

, 2018
Background: Atherosclerosis is a chronic inflammatory disease in part caused by lipid uptake in the vascular wall, but the exact underlying mechanisms leading to acute myocardial infarction and stroke remain poorly understood. Large consortia identified
Asselbergs, Folkert W, Björkegrenn, Johan L.M, de Bakker, Paul I.W, de Borst, Gert J., den Ruijter, Folkert W, Dichgans, Martin, Erdmann, Jeanette, Ford, Ian, Foroughi Asl, Hassan, Haitjema, Saskia, Hedin, Ulf, Malik, Rainer, Mokry, Michal, Pasterkamp, Gerard, Paulsson-Berne, Gabrielle, Perisic, Ljubica, Samani, Nilesh J, Sattar, Naveed, Schunkert, Heribert, Siemelink, Marten A., Stott, David J., van der Laan, Sander W., van Setten, Jessica, Worrall, Bradford B   +23 more
core   +2 more sources

The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI [PDF]

, 2012
Genome-wide association studies (GWAS) have demonstrated a significant polygenic contribution to bipolar disorder (BD) where disease risk is determined by the summation of many alleles of small individual magnitude. Modelling polygenic risk scores may be
A Bertolino, A McIntosh, A Mechelli, AM McIntosh, AM McIntosh, AM McIntosh, AM McIntosh, B Arts, C McDonald, C McDonald, CA Chaddock, CH Chen, D Arnone, D Drapier, DC Glahn, DC Nixon, DP Prata, E Perrier, E Sprooten, EA Osuch, F Wang, FY Womer, G Chakirova, G Delvecchio, H Y Tan, HC Whalley, HC Whalley, HC Whalley, HP Blumberg, HS Akiskal, HW Thermenos, HY Tan, II Gottesman, J Houenou, JA Frazier, JA Maldjian, KL Phan, KN Fountoulakis, M Hamilton, MA Cerullo, MB First, ML Phillips, ML Phillips, ML Phillips, MP Allin, N Craddock, N Craddock, N Tzourio-Mazoyer, P Burgess, P McGuffin, P Sklar, PA Bloom, PM Visscher, RC Young, S Alsabban, S Purcell, SA Papagni, SM Purcell, SM Strakowski, T Hajek, WC Drevets, Y Li   +61 more
core   +1 more source

Polygenic risk scores in familial Alzheimer disease [PDF]

Neurology, 2017
To investigate the association between a genetic risk score (GRS) and familial late-onset Alzheimer disease (LOAD) and its predictive value in families multiply affected by the disease.Using data from the National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease (National Institute on Aging-Late-Onset Alzheimer's Disease Family ...
Tosto, Giuseppe, Bird, Thomas D., Tsuang, Debby, Bennett, David A., Boeve, Bradley F., Cruchaga, Carlos, Faber, Kelley, Foroud, Tatiana M., Farlow, Martin, Goate, Alison M., Bertlesen, Sarah, Graff-Radford, Neill R., Medrano, Martin, Lantigua, Rafael, Manly, Jennifer, Ottman, Ruth, Rosenberg, Roger, Schaid, Daniel J., Schupf, Nicole, Stern, Yaakov, Sweet, Robert A., Mayeux, Richard   +21 more
openaire   +3 more sources

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Polygenic risk score analysis of pathologically confirmed Alzheimer's disease [PDF]

, 2017
Previous estimates of the utility of polygenic risk score analysis for the prediction of Alzheimer’s disease have given Area Under the Curve estimates of
Corneveaux, Escott-Price, Escott-Price, Huang, Jones, Karran, Lambert, Lee, Majounie, Marchini, Matarin   +10 more
core   +2 more sources

Genome‐Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes

Advanced Science, EarlyView.
This study explores genome‐wide by lifetime environment interactions on brain imaging phenotypes. Gene‐environment interactions explain more phenotypic variance than main effects, pinpoint regulatory variants, and reveal exposure‐specific biological pathways.
Sijia Wang, Meiyun Wang, Peng Zhang, Jingliang Cheng, Longjiang Zhang, Wenzhen Zhu, Shijun Qiu, Zuojun Geng, Guangbin Cui, Yongqiang Yu, Weihua Liao, Xi‐Nian Zuo, Hui Zhang, Bo Gao, Xiaojun Xu, Tong Han, Zhenwei Yao, Quan Zhang, Feng Liu, Qiang Xu, Jiayuan Xu, Jilian Fu, Nana Liu, Yuan Ji, Jie Tang, Lining Guo, Mengge Liu, Xiaoxiao Xiao, Xiaoxuan Liu, Wei Li, Caihong Wang, Wei Wei, Dapeng Shi, Su Lui, Zhihan Yan, Feng Chen, Jing Zhang, Wen Shen, Yanwei Miao, Dawei Wang, Jia‐Hong Gao, Yunjun Yang, Kai Xu, Junfang Xian, Bing Zhang, Xiaochu Zhang, Zhaoxiang Ye, Le Yu, Wen Qin, Meng Liang, Chunshui Yu, the CHIMGEN Consortium   +51 more
wiley   +1 more source

Predicting 10-Year Risk of Pancreatic Cancer Using a Combined Genetic and Clinical Model

Gastro Hep Advances, 2023
Background and Aims: Pancreatic cancer has the poorest 5-year survival rate of any major solid tumor, but when diagnosed at an early stage, survival rates improve. Population screening is impractical because pancreatic cancer is rare with a lifetime risk
Gillian S. Dite, Erika Spaeth, Chi Kuen Wong, Nicholas M. Murphy, Richard Allman   +4 more
doaj   +1 more source

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

Patient Perspectives on Personalized Risk Communication Using Polygenic Risk Scores to Inform Colorectal Cancer Screening Decisions

AJPM Focus
Introduction: Colorectal cancer is increasingly diagnosed in people aged
Shauna R. Goldberg, MPH, Linda K. Ko, PhD, Li Hsu, PhD, Hang Yin, MS, Charles Kooperberg, PhD, Ulrike Peters, PhD, MPH, Andrea N. Burnett-Hartman, PhD, MPH   +6 more
doaj   +1 more source