Results 1 to 10 of about 1,539 (210)

Inhibitory Potential of the Drimane Sesquiterpenoids Isotadeonal and Polygodial in the NF-kB Pathway [PDF]

Molecules
Inflammation contributes to the onset and development of many diseases, including neurodegenerative diseases, caused by the activation of microglia, leading to neurological deterioration. Nuclear factor-κB (NF-κB) is one of the most relevant pathways for
Víctor Marín, Cecilia Villegas, Ayorinde Víctor Ogundele, Jaime R. Cabrera-Pardo, Bernd Schmidt, Cristian Paz, Viviana Burgos   +6 more
doaj   +5 more sources

Investigating the Efficacy of Tasmannia lanceolata Extract in Inactivating Fungi and Prolonging the Shelf Life of Date Fruit [PDF]

Foods, 2022
Date palm (Phoenix dactylifera L.) is one of the world’s oldest cultivated plants. Post-harvest losses of date palm due to fungal contamination reached up to 50% of the total production.
Fahad Al-Asmari, Saleha Akter, Ram Mereddy, Yasmina Sultanbawa   +3 more
doaj   +6 more sources

Polygodial and Ophiobolin A Analogues for Covalent Crosslinking of Anticancer Targets. [PDF]

Int J Mol Sci, 2021
In a search of small molecules active against apoptosis-resistant cancer cells, including glioma, melanoma, and non-small cell lung cancer, we previously prepared α,β- and γ,δ-unsaturated ester analogues of polygodial and ophiobolin A, compounds capable ...
Maslivetc V, Laguera B, Chandra S, Dasari R, Olivier WJ, Smith JA, Bissember AC, Masi M, Evidente A, Mathieu V, Kornienko A.   +10 more
europepmc   +7 more sources

In Vitro and In Vivo Evaluation of the Antischistosomal Activity of Polygodial and 9-Deoxymuzigadial Isolated from Drimys brasiliensis Branches [PDF]

Molecules
In the present study, the hexane extract from branches of Drimys brasiliensis (Winteraceae) displayed potent activity against Schistosoma mansoni parasites (100% mortality of the worms at 200 μg/mL). Bioactivity-guided fractionation afforded, in addition
Eric Umehara, Rayssa A. Cajas, Gabriel B. Conceição, Guilherme M. Antar, Adriano D. Andricopulo, Josué de Moraes, João Henrique G. Lago   +6 more
doaj   +3 more sources

A re‐innervated in vitro skin model of non‐histaminergic itch and skin neurogenic inflammation: PAR2‐, TRPV1‐ and TRPA1‐agonist induced functionality [PDF]

Skin Health and Disease, 2021
Background Skin, and epidermis, is innervated by sensory nerve fibres. Interactions between them and signal transduction are only partially elucidated in physiological/pathological conditions, especially in pruritus.
N. Lebonvallet, J. W. Fluhr, C. Le Gall‐Ianotto, R. Leschiera, M. Talagas, A. Reux, A. Bataille, C. Brun, T. Oddos, J.‐P. Pennec, J.‐L. Carré, L. Misery   +11 more
doaj   +3 more sources

Botanical Control of Citrus Green Mold and Peach Brown Rot on Fruits Assays Using a Persicaria acuminata Phytochemically Characterized Extract [PDF]

Plants, 2021
Persicaria acuminata (Polygonaceae) is a perennial herb that grows in the central area of Argentina and it is commonly used by native populations to heal infected wounds and other conditions related to fungal infections.
Melina G. Di Liberto, Gisela M. Seimandi, Laura N. Fernández, Verónica E. Ruiz, Laura A. Svetaz, Marcos G. Derita   +5 more
doaj   +5 more sources

Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in Saccharomyces cerevisiae. [PDF]

Int J Mol Sci, 2021
Polygodial is a “hot” peppery-tasting sesquiterpenoid that was first described for its anti-feedant activity against African armyworms. Using the haploid deletion mutant library of Saccharomyces cerevisiae, a genome-wide mutant screen was performed to ...
Kipanga PN, Demuyser L, Vrijdag J, Eskes E, D'hooge P, Matasyoh J, Callewaert G, Winderickx J, Van Dijck P, Luyten W.   +9 more
europepmc   +2 more sources

Polygodial, a Sesquiterpene Dialdehyde, Activates Apoptotic Signaling in Castration-Resistant Prostate Cancer Cell Lines by Inducing Oxidative Stress. [PDF]

Cancers (Basel), 2022
Simple Summary Prostate cancer (PCa) is the second leading cause of cancer death in men in the United States. The emergence of resistance to androgen deprivation therapy results in castration-resistant prostate cancer (CRPC) development.
Venkatesan R, Hussein MA, Moses L, Liu JS, Khetani SR, Kornienko A, Munirathinam G.   +6 more
europepmc   +2 more sources

Biopesticide Activity from Drimanic Compounds to Control Tomato Pathogens [PDF]

Molecules, 2018
Tomato crops can be affected by several infectious diseases produced by bacteria, fungi, and oomycetes. Four phytopathogens are of special concern because of the major economic losses they generate worldwide in tomato production; Clavibacter ...
Iván Montenegro, Alejandro Madrid, Mauricio Cuellar, Michael Seeger, Juan Felipe Alfaro, Ximena Besoain, Juan Pablo Martínez, Ingrid Ramirez, Yusser Olguín, Miryam Valenzuela   +9 more
doaj   +3 more sources

Neuronal ion channel modulation by Drimys winteri compounds: Opening a new chemical space to neuropharmacology [PDF]

Neural Regeneration Research
Numerous pathological states of the nervous system involve alterations in neuronal excitability and synaptic dysfunction, which depend on the function of ion channels.
Macarena E. Meza, Oscar Ramirez-Molina, Oscar Flores, Katherine Fariña-Oliva, Pamela A. Godoy, Jorge Fuentealba, Gonzalo E. Yévenes   +6 more
doaj   +2 more sources