Results 11 to 20 of about 444 (156)

Antibacterial and Antifungal Terpenes from the Medicinal Angiosperms of Asia and the Pacific: Haystacks and Gold Needles [PDF]

Molecules, 2023
This review identifies terpenes isolated from the medicinal Angiosperms of Asia and the Pacific with antibacterial and/or antifungal activities and analyses their distribution, molecular mass, solubility, and modes of action. All data in this review were
Christophe Wiart, Geethanjali Kathirvalu, Chandramathi Samudi Raju, Veeranoot Nissapatorn, Mohammed Rahmatullah, Alok K. Paul, Mogana Rajagopal, Jaya Seelan Sathiya Seelan, Nor Azizun Rusdi, Scholastica Lanting, Mazdida Sulaiman   +10 more
doaj   +2 more sources

9-Deoxymuzigadial, a Sesquiterpene Isolated From Drimys brasiliensis (Winteraceae), Displays Reduced Cytotoxicity In Vitro and Modulates Leukocyte Activity and Fibrogenesis In Vivo. [PDF]

Chem Biodivers
ABSTRACT The aims of this study were to investigate in vitro cytotoxic potential and the effects of daily administration during the inflammatory response induced by sponge implants in mice of the sesquiterpene 9‐deoxymuzigadial (9‐DOM), isolated from Drimys brasiliensis (Winteraceae).
Ferreira BA, Cassimiro IS, de Moura FBR, de Campos Lima T, Napolitano DR, Umehara E, Lago JHG, Araújo FA.   +7 more
europepmc   +2 more sources

Effect of Thermal and Freeze-Drying on the Volatile Composition of Mountain Horopito (Pseudowintera colorata) and Kawakawa (Piper excelsum). [PDF]

J Food Sci
ABSTRACT Mountain horopito (Pseudowintera colorata) and kawakawa (Piper excelsum) are plants endemic to Aotearoa|New Zealand with cultural and medicinal importance for Indigenous Māori. These plants have also become popular in food applications. Drying is an important preservation technique for extending the shelf life of herbs, which alters the ...
Ham EE, Subbaraj A, Deb-Choudhury S, Burrow K, Morton JD, Torrico DD, O'Connor C, Smith K, Realini CE.   +8 more
europepmc   +2 more sources

Polygodial and Ophiobolin A Analogues for Covalent Crosslinking of Anticancer Targets. [PDF]

Int J Mol Sci, 2021
In a search of small molecules active against apoptosis-resistant cancer cells, including glioma, melanoma, and non-small cell lung cancer, we previously prepared α,β- and γ,δ-unsaturated ester analogues of polygodial and ophiobolin A, compounds capable of pyrrolylation of primary amines and demonstrating double-digit micromolar antiproliferative ...
Maslivetc V, Laguera B, Chandra S, Dasari R, Olivier WJ, Smith JA, Bissember AC, Masi M, Evidente A, Mathieu V, Kornienko A.   +10 more
europepmc   +6 more sources

Screening the Tocriscreen™ bioactive compound library in search for inhibitors of Candida biofilm formation. [PDF]

APMIS, 2022
Biofilms formed by Candida species present a significant clinical problem due to the ineffectiveness of many conventional antifungal agents, in particular the azole class. We urgently require new and clinically approved antifungal agents quickly for treatment of critically ill patients.
Abduljalil H, Bakri A, Albashaireh K, Alshanta OA, Brown JL, Sherry L, Kean R, Nile C, McLean W, Ramage G.   +9 more
europepmc   +2 more sources

Microbial and metabolomic profiles of type 1 diabetes with depression: A case-control study. [PDF]

J Diabetes
Highlights Type 1 diabetes (T1D) patients with depression were characterized by unique profiles of gut microbiota and serum metabolites. Phascolarctobacterium, Butyricimonas, and Alistipes could predict the risk of T1D with depression. Abstract Background Depression is the most common psychological disorder in patients with type 1 diabetes (T1D ...
Liu Z, Yue T, Zheng X, Luo S, Xu W, Yan J, Weng J, Yang D, Wang C.   +8 more
europepmc   +2 more sources

Metamorphosis of the invasive ascidian Ciona savignyi: environmental variables and chemical exposure [PDF]

PeerJ, 2016
In this study, the effects of environmental variables on larval metamorphosis of the solitary ascidian Ciona savignyi were investigated in a laboratory setting.
Patrick L. Cahill, Javier Atalah, Andrew I. Selwood, Jeanne M. Kuhajek   +3 more
doaj   +2 more sources

Mode of Action of Polygodial, an Antifungal Sesquiterpene Dialdehyde [PDF]

Agricultural and Biological Chemistry, 1988
The mechanism of polygodial antifungal action was studied using Saccharomyces cerevisiae. It inhibited the incorporation of radioactive precursors into macromolecules in whole cells. However, no specificity in the inhibition of precursor incorporation was observed among various species of macromolecules, i.e., DNA, RNA, protein, and polysaccharide.
TANIGUCHI, Makoto, YANO, Yoshihisa, TADA, Etsuo, IKENISHI, Kohji, OI, Susumu, HARAGUCHI, Hiroyuki, HASHIMOTO, Kensuke, KUBO, Isao   +7 more
openaire   +2 more sources

Effect of Polygodial on the Mitochondrial ATPase of Saccharomyces cerevisiae [PDF]

Antimicrobial Agents and Chemotherapy, 2000
ABSTRACT The fungicidal mechanism of a naturally occurring sesquiterpene dialdehyde, polygodial, was investigated in Saccharomyces cerevisiae . In an acidification assay, polygodial completely suppressed the glucose-induced decrease in external pH at 3.13 μg/ml, the same as the fungicidal concentration ...
C S, Lunde, I, Kubo
openaire   +2 more sources

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

British Journal of Pharmacology, Volume 180, Issue S2, Page S145-S222, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jörg Striessnig, Eamonn Kelly, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Alex C. Conner, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, Chandy George, Steve A. N. Goldstein, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Perez‐Reyes, Leigh D. Plant, Lachlan Rash, Dejian Ren, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Joris Vriens, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Wei Fang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +72 more
wiley   +1 more source