Polygodial, the fungitoxic component from the Brazilian medicinal plant Polygonum punctatum [PDF]
Memorias do Instituto Oswaldo Cruz, 2001 Polygonum punctatum (Polygonaceae) is an herb known in some regions of Brazil as "erva-de-bicho" and is used to treat intestinal disorders. The dichloromethane extract of the aerial parts of this plant showed strong activity in a bioautographic assay ...
Tânia Maria de Almeida Alves +3 more
doaj +12 more sources
The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK [PDF]
Frontiers in Pharmacology, 2013 For a long time, the focus of trigeminal chemoperception has rested almost exclusively on TRP channels. However, two-pore domain (K2P) potassium channels have recently been identified as targets for substances associated with typical trigeminal ...
Leopoldo Raul Beltran +7 more
doaj +2 more sources
9-Deoxymuzigadial, a Sesquiterpene Isolated From Drimys brasiliensis (Winteraceae), Displays Reduced Cytotoxicity In Vitro and Modulates Leukocyte Activity and Fibrogenesis In Vivo. [PDF]
Chem BiodiversABSTRACT The aims of this study were to investigate in vitro cytotoxic potential and the effects of daily administration during the inflammatory response induced by sponge implants in mice of the sesquiterpene 9‐deoxymuzigadial (9‐DOM), isolated from Drimys brasiliensis (Winteraceae).
Ferreira BA +7 more
europepmc +2 more sources
Polygodial and Ophiobolin A Analogues for Covalent Crosslinking of Anticancer Targets [PDF]
International Journal of Molecular Sciences, 2021 Alex Bissember +2 more
exaly +2 more sources
Screening the Tocriscreen™ bioactive compound library in search for inhibitors of Candida biofilm formation. [PDF]
APMIS, 2022 Biofilms formed by Candida species present a significant clinical problem due to the ineffectiveness of many conventional antifungal agents, in particular the azole class. We urgently require new and clinically approved antifungal agents quickly for treatment of critically ill patients.
Abduljalil H +9 more
europepmc +2 more sources
Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in Saccharomyces cerevisiae. [PDF]
Int J Mol Sci, 2021 Polygodial is a "hot" peppery-tasting sesquiterpenoid that was first described for its anti-feedant activity against African armyworms. Using the haploid deletion mutant library of Saccharomyces cerevisiae, a genome-wide mutant screen was performed to ...
Kipanga PN +9 more
europepmc +2 more sources
Microbial and metabolomic profiles of type 1 diabetes with depression: A case-control study. [PDF]
J DiabetesHighlights Type 1 diabetes (T1D) patients with depression were characterized by unique profiles of gut microbiota and serum metabolites. Phascolarctobacterium, Butyricimonas, and Alistipes could predict the risk of T1D with depression. Abstract Background Depression is the most common psychological disorder in patients with type 1 diabetes (T1D ...
Liu Z +8 more
europepmc +2 more sources
Effects of the antifeedant polygodial on plant penetration by aphids, assessed by video and electrical recording [PDF]
, 1993 Adult apterous Myzus persicae (Sulz.) discriminated within 2 min between mature Chinese cabbage (Brassica pekinensis L.) leaf halves treated with (+/-)-polygodial solution and solvent alone, and walked off leaf areas treated with polygodial faster than ...
J. A. Pickett +5 more
core +3 more sources
Polygodial, a drimane sesquiterpenoid dialdehyde purified from Drimys winteri, inhibits voltage-gated sodium channels [PDF]
, 2022 Drimys winteri J.R.Forst. & G.Forst, a South American evergreen shrub that is used by the Mapuche people for treatment of several painful conditions, contains polygodial, a lipophilic drimane-type sesquiterpene dialdehyde with known activity at transient
Cristian Paz (4219627) +3 more
core +1 more source
Metamorphosis of the invasive ascidian Ciona savignyi: environmental variables and chemical exposure [PDF]
PeerJ, 2016 In this study, the effects of environmental variables on larval metamorphosis of the solitary ascidian Ciona savignyi were investigated in a laboratory setting.
Patrick L. Cahill +3 more
doaj +2 more sources