Results 1 to 10 of about 444 (156)

Inhibitory Potential of the Drimane Sesquiterpenoids Isotadeonal and Polygodial in the NF-kB Pathway [PDF]

Molecules
Inflammation contributes to the onset and development of many diseases, including neurodegenerative diseases, caused by the activation of microglia, leading to neurological deterioration. Nuclear factor-κB (NF-κB) is one of the most relevant pathways for
Bernd Schmidt, Cristian Paz, Ayorinde Víctor Ogundele   +2 more
exaly   +6 more sources

Investigating the Efficacy of Tasmannia lanceolata Extract in Inactivating Fungi and Prolonging the Shelf Life of Date Fruit [PDF]

Foods, 2022
Date palm (Phoenix dactylifera L.) is one of the world’s oldest cultivated plants. Post-harvest losses of date palm due to fungal contamination reached up to 50% of the total production.
Fahad Al-Asmari, Saleha Akter, Ram Mereddy, Yasmina Sultanbawa   +3 more
doaj   +2 more sources

Semisynthetic Derivatives of Polygodial as α-Glucosidase and α-Amylase Inhibitors: In Vitro Evaluation, Molecular Docking and Molecular Dynamics Simulation [PDF]

Pharmaceutics
Background: Polygodial (9), a drimane sesquiterpene dialdehyde from Drimys winteri, has not previously been examined against carbohydrate-hydrolyzing enzymes.
Viviana Burgos, Cecilia Villegas, Carlos Sanzana, Benjamin Oporto, Bernd Schmidt, Vaderament-Alexe Nchiozem-Ngnitedem, Muhammad Javid Iqbal, Cristian Paz   +7 more
doaj   +2 more sources

Neuronal ion channel modulation by Drimys winteri compounds: Opening a new chemical space to neuropharmacology [PDF]

Neural Regeneration Research
Numerous pathological states of the nervous system involve alterations in neuronal excitability and synaptic dysfunction, which depend on the function of ion channels.
Macarena E. Meza, Oscar Ramirez-Molina, Oscar Flores, Katherine Fariña-Oliva, Pamela A. Godoy, Jorge Fuentealba, Gonzalo E. Yévenes   +6 more
doaj   +2 more sources

In Vitro and In Vivo Evaluation of the Antischistosomal Activity of Polygodial and 9-Deoxymuzigadial Isolated from Drimys brasiliensis Branches [PDF]

Molecules
In the present study, the hexane extract from branches of Drimys brasiliensis (Winteraceae) displayed potent activity against Schistosoma mansoni parasites (100% mortality of the worms at 200 μg/mL). Bioactivity-guided fractionation afforded, in addition
Eric Umehara, Rayssa A. Cajas, Gabriel B. Conceição, Guilherme M. Antar, Adriano D. Andricopulo, Josué de Moraes, João Henrique G. Lago   +6 more
doaj   +2 more sources

A re‐innervated in vitro skin model of non‐histaminergic itch and skin neurogenic inflammation: PAR2‐, TRPV1‐ and TRPA1‐agonist induced functionality [PDF]

Skin Health and Disease, 2021
Background Skin, and epidermis, is innervated by sensory nerve fibres. Interactions between them and signal transduction are only partially elucidated in physiological/pathological conditions, especially in pruritus.
N. Lebonvallet, J. W. Fluhr, C. Le Gall‐Ianotto, R. Leschiera, M. Talagas, A. Reux, A. Bataille, C. Brun, T. Oddos, J.‐P. Pennec, J.‐L. Carré, L. Misery   +11 more
doaj   +2 more sources

Antimicrobial Activity of Drimanic Sesquiterpene Compounds from Drimys winteri against Multiresistant Microorganisms [PDF]

Molecules
In this work, a group of ten sesquiterpene drimanes, including polygodial (1), isopolygodial (2), and drimenol (3) obtained from the bark of Drimys winteri F. and seven synthetic derivatives, were tested in vitro against a unique panel of bacteria, fungi,
Iván Montenegro, Rolando Pazmiño, Ileana Araque, Alejandro Madrid, Ximena Besoain, Enrique Werner, Luis Espinoza-Catalán, Andrés F. Olea, Claudio Parra, Valentina Navarrete Molina, Patricio Godoy, Yusser Olguín, Mauricio A. Cuellar   +12 more
doaj   +2 more sources

Assessment of Phytochemical Composition and Antifungal Activity of Micropropagated Drymis winteri Plants [PDF]

Plants
The search for sustainable alternatives to synthetic agrochemicals has fueled a growing interest in plant-derived bioactive compounds. Drimys winteri (canelo), a native Chilean tree of significant ethnobotanical importance, is a promising source of ...
Julia Rubio, Christian Robles-Kelly, Evelyn Silva-Moreno, Héctor Carrasco, Andrés F. Olea   +4 more
doaj   +2 more sources

Anti-Inflammatory and Analgesic Properties of Polygonum minus: Mechanistic Insights and Therapeutic Potential [PDF]

Biomedicines
Inflammation is a complex protective biological response triggered by harmful stimuli such as pathogens, chemical agents, or physical injury, and is closely associated with the development of pain and various chronic diseases.
Mohd Amir Kamaruzzaman, Ruzaidi Ruslan, Isma Liza Mohd Isa, Nur Aqilah Kamaruddin, Elvy Suhana Mohd Ramli   +4 more
doaj   +2 more sources

Application of the herbal chemical marker ranking system (Herb MaRS) to the standardization of herbal raw materials: a case study [PDF]

BMC Complementary Medicine and Therapies, 2023
Introduction Phytochemical standardization of herbal materials involves establishing consistent levels of one or more active ingredients or markers. It ensures the authenticity and quality of herbal materials, extracts, and their products.
Bruhan Kaggwa, Godwin Anywar, Edson Ireeta Munanura, Raphael Wangalwa, Henry Kyeyune, Hedmon Okella, Fadhiru Pakoyo Kamba, Ogwang Patrick Engeu   +7 more
doaj   +2 more sources