Results 1 to 10 of about 423 (152)

Inhibitory Potential of the Drimane Sesquiterpenoids Isotadeonal and Polygodial in the NF-kB Pathway [PDF]

Molecules
Inflammation contributes to the onset and development of many diseases, including neurodegenerative diseases, caused by the activation of microglia, leading to neurological deterioration. Nuclear factor-κB (NF-κB) is one of the most relevant pathways for
Ayorinde VÍCTOR Ogundele, Bernd Schmidt, Cristian Paz   +2 more
exaly   +6 more sources

Investigating the Efficacy of Tasmannia lanceolata Extract in Inactivating Fungi and Prolonging the Shelf Life of Date Fruit [PDF]

Foods, 2022
Date palm (Phoenix dactylifera L.) is one of the world’s oldest cultivated plants. Post-harvest losses of date palm due to fungal contamination reached up to 50% of the total production.
Fahad Al-Asmari, Saleha Akter, Ram Mereddy, Yasmina Sultanbawa   +3 more
doaj   +2 more sources

Polygodial and Ophiobolin A Analogues for Covalent Crosslinking of Anticancer Targets. [PDF]

Int J Mol Sci, 2021
In a search of small molecules active against apoptosis-resistant cancer cells, including glioma, melanoma, and non-small cell lung cancer, we previously prepared α,β- and γ,δ-unsaturated ester analogues of polygodial and ophiobolin A, compounds capable of pyrrolylation of primary amines and demonstrating double-digit micromolar antiproliferative ...
Maslivetc V, Laguera B, Chandra S, Dasari R, Olivier WJ, Smith JA, Bissember AC, Masi M, Evidente A, Mathieu V, Kornienko A.   +10 more
europepmc   +6 more sources

Neuronal ion channel modulation by Drimys winteri compounds: Opening a new chemical space to neuropharmacology [PDF]

Neural Regeneration Research
Numerous pathological states of the nervous system involve alterations in neuronal excitability and synaptic dysfunction, which depend on the function of ion channels.
Macarena E. Meza, Oscar Ramirez-Molina, Oscar Flores, Katherine Fariña-Oliva, Pamela A. Godoy, Jorge Fuentealba, Gonzalo E. Yévenes   +6 more
doaj   +2 more sources

9-Deoxymuzigadial, a Sesquiterpene Isolated From Drimys brasiliensis (Winteraceae), Displays Reduced Cytotoxicity In Vitro and Modulates Leukocyte Activity and Fibrogenesis In Vivo. [PDF]

Chem Biodivers
ABSTRACT The aims of this study were to investigate in vitro cytotoxic potential and the effects of daily administration during the inflammatory response induced by sponge implants in mice of the sesquiterpene 9‐deoxymuzigadial (9‐DOM), isolated from Drimys brasiliensis (Winteraceae).
Ferreira BA, Cassimiro IS, de Moura FBR, de Campos Lima T, Napolitano DR, Umehara E, Lago JHG, Araújo FA.   +7 more
europepmc   +2 more sources

Screening the Tocriscreen™ bioactive compound library in search for inhibitors of Candida biofilm formation. [PDF]

APMIS, 2022
Biofilms formed by Candida species present a significant clinical problem due to the ineffectiveness of many conventional antifungal agents, in particular the azole class. We urgently require new and clinically approved antifungal agents quickly for treatment of critically ill patients.
Abduljalil H, Bakri A, Albashaireh K, Alshanta OA, Brown JL, Sherry L, Kean R, Nile C, McLean W, Ramage G.   +9 more
europepmc   +2 more sources

A re‐innervated in vitro skin model of non‐histaminergic itch and skin neurogenic inflammation: PAR2‐, TRPV1‐ and TRPA1‐agonist induced functionality [PDF]

Skin Health and Disease, 2021
Background Skin, and epidermis, is innervated by sensory nerve fibres. Interactions between them and signal transduction are only partially elucidated in physiological/pathological conditions, especially in pruritus.
N. Lebonvallet, J. W. Fluhr, C. Le Gall‐Ianotto, R. Leschiera, M. Talagas, A. Reux, A. Bataille, C. Brun, T. Oddos, J.‐P. Pennec, J.‐L. Carré, L. Misery   +11 more
doaj   +2 more sources

In Vitro and In Vivo Evaluation of the Antischistosomal Activity of Polygodial and 9-Deoxymuzigadial Isolated from Drimys brasiliensis Branches [PDF]

Molecules
In the present study, the hexane extract from branches of Drimys brasiliensis (Winteraceae) displayed potent activity against Schistosoma mansoni parasites (100% mortality of the worms at 200 μg/mL). Bioactivity-guided fractionation afforded, in addition
Eric Umehara, Rayssa A. Cajas, Gabriel B. Conceição, Guilherme M. Antar, Adriano D. Andricopulo, Josué de Moraes, João Henrique G. Lago   +6 more
doaj   +2 more sources

Antimicrobial Activity of Drimanic Sesquiterpene Compounds from Drimys winteri against Multiresistant Microorganisms [PDF]

Molecules
In this work, a group of ten sesquiterpene drimanes, including polygodial (1), isopolygodial (2), and drimenol (3) obtained from the bark of Drimys winteri F. and seven synthetic derivatives, were tested in vitro against a unique panel of bacteria, fungi,
Iván Montenegro, Rolando Pazmiño, Ileana Araque, Alejandro Madrid, Ximena Besoain, Enrique Werner, Luis Espinoza-Catalán, Andrés F. Olea, Claudio Parra, Valentina Navarrete Molina, Patricio Godoy, Yusser Olguín, Mauricio A. Cuellar   +12 more
doaj   +2 more sources

Assessment of Phytochemical Composition and Antifungal Activity of Micropropagated Drymis winteri Plants [PDF]

Plants
The search for sustainable alternatives to synthetic agrochemicals has fueled a growing interest in plant-derived bioactive compounds. Drimys winteri (canelo), a native Chilean tree of significant ethnobotanical importance, is a promising source of ...
Julia Rubio, Christian Robles-Kelly, Evelyn Silva-Moreno, Héctor Carrasco, Andrés F. Olea   +4 more
doaj   +2 more sources