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International Journal of Toxicology, 2020
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of Polyaminopropyl Biguanide (polyhexamethylene biguanide hydrochloride), which functions as a preservative in cosmetic products. The Panel reviewed relevant data relating to the safety of this ingredient and concluded that Polyaminopropyl Biguanide is safe in cosmetics in the ...
Wilbur Johnson +2 more
exaly +3 more sources
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of Polyaminopropyl Biguanide (polyhexamethylene biguanide hydrochloride), which functions as a preservative in cosmetic products. The Panel reviewed relevant data relating to the safety of this ingredient and concluded that Polyaminopropyl Biguanide is safe in cosmetics in the ...
Wilbur Johnson +2 more
exaly +3 more sources
Effect of a polyhexamethylene biguanide mouthrinse on bacterial counts and plaque
Journal of Clinical Periodontology, 2001AbstractObjectives: For various clinical applications, polyhexamethylene biguanide (PHMB) has been used for many years as an antiseptic in medicine. Little is known, however, of its antibacterial activity in the oral cavity and its ability to inhibit plaque formation.
M Rosin, Axel Kramer
exaly +3 more sources
Polyhexamethylene biguanide is a relevant sensitizer in wet wipes
Contact Dermatitis, 2014An Goossens, Olivier Aerts
exaly +4 more sources
Treatment of Acanthamoeba Keratitis with Polyhexamethylene Biguanide
Ophthalmology, 1992Polyhexamethylene biguanide (PHMB) is a polymeric biguanide disinfectant that has not previously been used in the treatment of infection. Six patients with confirmed Acanthamoeba keratitis were treated with PHMB 0.02%. All patients had uncontrolled keratitis refractory to therapy with multiple conventional antiamebic agents.
D F, Larkin, S, Kilvington, J K, Dart
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Effect of polyhexamethylene biguanide on rat liver
Toxicology Letters, 2018Polyhexamethylene biguanide (PHMB), an amphiphilic polymeric biocide, increased liver tumor incidence in male and female rats at 1000 and 1500 mg/L in drinking water, but not at 500 mg/L in previous studies. In another study, PHMB administered in diet at 4000 mg/kg was negative for hepatocellular tumors.
Aparajita, Chowdhury +9 more
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Synergism within polyhexamethylene biguanide biocide formulations
Journal of Applied Bacteriology, 1990G ilbert , P., P emberton , D. & W ilkinson , D.E. 1990. Synergism within polyhexamethylene biguanide biocide formulations. Journal of Applied Bacteriology 69
P, Gilbert, D, Pemberton, D E, Wilkinson
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Environmental Fate of Polyhexamethylene Biguanide
Bulletin of Environmental Contamination and Toxicology, 2011Polyhexamethylene biguanide (PHMB) is used as a bacteriocidal agent in a variety of applications from medical devices to pools, but is highly toxic to some aquatic species. The stability of PHMB in various environmental matrices was examined. 80% of PHMB was present in fortified creek samples after 20 days, but bound immediately to soils with the ...
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Polyhexamethylene biguanide dressings in wound management
Nursing Standard, 2011This article describes wound management using polyhexamethylene biguanide dressings in two patients experiencing multiple comorbidities. Wound bed debridement and bioburden management were important factors in achieving positive results in terms of promoting wound healing and reducing infection and malodour.
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Treatment of Nocardia asteroides Keratitis with Polyhexamethylene Biguanide
Ophthalmology, 1997Polyhexamethylene biguanide (PHMB) is a polymeric biguanide disinfectant that has been used previously in the treatment of Acanthamoeba keratitis. The authors report the first case of Nocardia asteroides keratitis treated successfully with PHMB. Further studies documenting the efficacy of PHMB against N.
J C, Lin +4 more
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