Safety study, anti-inflammatory and antioxidant action of drug caramel with polyhexamethylene guanidine phosphate [PDF]
International Journal of Basic and Clinical Pharmacology, 2016 Background: Among the new antiseptic medicines, most meeting modern requirements in terms of treatment of microbial invasion are one of the leading positions occupied by the polymeric guanidine compound.
Belenichev, Igor F. +2 more
core +4 more sources
Association between humidifier disinfectant use duration and lung cancer development in Korea [PDF]
Epidemiology and HealthOBJECTIVES This study was conducted to assess the association between the duration of humidifier disinfectant use and lung cancer development. METHODS We analyzed data from 3,605 applicants registered for compensation from the Korean government due to ...
Sungchan Kang +10 more
doaj +2 more sources
Assessment of the Diagnostic Value of [68Ga]Ga-FAPI-04 and [18F]FDG PET in a PHMG-p-Induced Pulmonary Fibrosis Murine Model [PDF]
DiagnosticsBackground/Objectives: Pulmonary fibrosis is a progressive and fatal lung disease with limited diagnostic and therapeutic options. Fibroblast activation protein (FAP) has emerged as a promising molecular imaging target for the non-invasive assessment of ...
So Young Kim +3 more
doaj +2 more sources
Concentration-dependent aerosol size alters regional deposition and inhalation dose translation [PDF]
Scientific ReportsInhalation toxicity assessment relies heavily on quantifying both atmospheric concentration (AC) and region-specific internal dose (ID) within the respiratory tract, especially when comparing in vivo toxicity tests with in vitro respiratory cellular ...
Yurim Choi, Ha Ryong Kim, Jung-Hwan Kwon
doaj +2 more sources
Comparison of maternal and neonatal survival exposed to humidifier disinfectants during perinatal periods: a case-series study. [PDF]
Sci Rep, 2023 A humidifier disinfectant (HD) has been prohibited by the government due to its serious effects on the human body. Several studies on the relationship between HD and lung diseases have been performed independently on children and adults.
Lee JH, Joh JS, Choi S.
europepmc +3 more sources
Polyhexamethylene Guanidine Phosphate Induces Apoptosis through Endoplasmic Reticulum Stress in Lung Epithelial Cells. [PDF]
Int J Mol Sci, 2021 Airway epithelial cell death contributes to the pathogenesis of lung fibrosis. Polyhexamethylene guanidine phosphate (PHMG-p), commonly used as a disinfectant, has been shown to be strongly associated with lung fibrosis in epidemiological and toxicological studies.
Jeong MH, Jeon MS, Kim GE, Kim HR.
europepmc +4 more sources
Enhancing Lesion Detection in Rat CT Images: A Deep Learning-Based Super-Resolution Study [PDF]
BiomedicinesBackground/Objectives: Preclinical chest computed tomography (CT) imaging in small animals is often limited by low resolution due to scan time and dose constraints, which hinders accurate detection of subtle lesions.
Sungwon Ham +13 more
doaj +2 more sources
Toxicological evidence integration to confirm the biological plausibility of the association between humidifier disinfectant exposure and respiratory diseases using the AEP-AOP framework [PDF]
Epidemiology and HealthOBJECTIVES Exposure to humidifier disinfectants has been linked to respiratory diseases, including interstitial lung disease, asthma, and pneumonia. Consequently, numerous toxicological studies have explored respiratory damage as both a necessary and ...
Ha Ryong Kim +10 more
doaj +2 more sources
Ecotoxicology and Environmental SafetyIn this study, we investigated the potential mechanisms by which polyhexamethylene guanidine phosphate (PHMG-p), a known respiratory irritant, may contribute to lung cancer development.
Yong Joo Park +7 more
doaj +3 more sources
Микрофлюидный метод как перспективная технология для синтеза антимикробных соединений [PDF]
, 2022 Objectives. The study aimed to analyze the current antiseptics and disinfectants, explore the possibility of synthesizing various antiseptics including oligohexamethylene guanidine hydrochloride (OHMG-HC) using microfluidic technology, and investigate ...
A. С. Ha, А. К. Ха
core +2 more sources