Results 11 to 20 of about 155 (82)

Longitudinal long term follow up investigation on the carcinogenic impact of polyhexamethylene guanidine phosphate in rat models [PDF]

Scientific Reports
Polyhexamethylene guanidine phosphate (PHMG-p) is a major component in humidifier disinfectants, which cause life-threatening lung injuries. However, to our knowledge, no published studies have investigated associations between PHMG-p dose and lung ...
Sang Hoon Jeong, Hong Lee, Yoon Jeong Nam, Ja Young Kang, Hyejin Lee, Jin Young Choi, Yu-Seon Lee, Jaeyoung Kim, Yoon Hee Park, Su A. Park, Hangseok Choi, Eun-Kee Park, Yong-Wook Baek, Jungyun Lim, Suejin Kim, Cherry Kim, Ju-Han Lee   +16 more
doaj   +2 more sources

Polyhexamethylene Guanidine Phosphate Damages Tight Junctions and the F-Actin Architecture by Activating Calpain-1 via the P2RX7/Ca²⁺ Signaling Pathway [PDF]

Cells, 2019
Polyhexamethylene guanidine phosphate (PHMG-p), a member of the polymeric guanidine family, has strong antimicrobial activity and may increase the risk of inflammation-associated pulmonary fibrosis.
Sun Woo Jin, Gi Ho Lee, Hoa Thi Pham, Jae Ho Choi, Hye Gwang Jeong   +4 more
doaj   +2 more sources

Polyhexamethylene guanidine phosphate increases stress granule formation in human 3D lung organoids under respiratory syncytial virus infection

Ecotoxicology and Environmental Safety, 2022
Polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, is known to cause lung toxicity, including inflammation and pulmonary fibrosis.
Seri Choi, Sunkyung Choi, Yeongsoo Choi, Namjoon Cho, Seung-Yeon Kim, Chang Hyun Lee, Han-Jin Park, Won Keun Oh, Kee K. Kim, Eun-Mi Kim   +9 more
doaj   +1 more source

A review of current studies on cellular and molecular mechanisms underlying pulmonary fibrosis induced by chemicals [PDF]

Environmental Health and Toxicology, 2018
Several studies showed that the inflammatory and fibrotic responses induced by polyhexamethylene guanidine phosphate (PHMG-p) were similar to those observed for idiopathic pulmonary fibrosis in South Korea in 2011.
Ha Ryong Kim, Da Young Shin, Kyu Hyuck Chung   +2 more
doaj   +1 more source

Fibrinogen on extracellular vesicles derived from polyhexamethylene guanidine phosphate-exposed mice induces inflammatory effects via integrin β

Ecotoxicology and Environmental Safety, 2023
Polyhexamethylene guanidine phosphate (PHMG-p), used as a humidifier disinfectant, causes interstitial lung disease, obliterative bronchiolitis, and lung fibrosis; however, little is known about its effect on intercellular interactions.
Jun Woo Kim, Mi Ho Jeong, Hyeong Tae Yu, Yong Joo Park, Hyung Sik Kim, Kyu Hyuck Chung   +5 more
doaj   +1 more source

A Phenotypic and Genotypic Evaluation of Developmental Toxicity of Polyhexamethylene Guanidine Phosphate Using Zebrafish Embryo/Larvae

Toxics, 2020
Polyhexamethylene guanidine-phosphate (PHMG-P), a guanidine-based cationic antimicrobial polymer, is an effective antimicrobial biocide, potent even at low concentrations.
Jeongah Song, Kojo Eghan, Sangwoo Lee, Jong-Su Park, Seokjoo Yoon, Wittaya Pimtong, Woo-Keun Kim   +6 more
doaj   +1 more source

Additional file 3 of Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells

, 2022
Additional file 3. Supplementary table 2.
Lee, Hong, Jeong, Sang Hoon, Lee, Hyejin, Kim, Cherry, Nam, Yoon Jeong, Kang, Ja Young, Song, Myeong Ok, Choi, Jin Young, Kim, Jaeyoung, Park, Eun-Kee, Baek, Yong-Wook, Lee, Ju-Han   +11 more
openaire   +1 more source

Additional file 1 of Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells

, 2022
Additional file 1. Supplementary Figure 1. Clinical significance of selected genes in patient with lung adenocarcinoma.
Lee, Hong, Jeong, Sang Hoon, Lee, Hyejin, Kim, Cherry, Nam, Yoon Jeong, Kang, Ja Young, Song, Myeong Ok, Choi, Jin Young, Kim, Jaeyoung, Park, Eun-Kee, Baek, Yong-Wook, Lee, Ju-Han   +11 more
openaire   +1 more source

Additional file 2 of Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells

, 2022
Additional file 2. Supplementary Table 1.
Lee, Hong, Jeong, Sang Hoon, Lee, Hyejin, Kim, Cherry, Nam, Yoon Jeong, Kang, Ja Young, Song, Myeong Ok, Choi, Jin Young, Kim, Jaeyoung, Park, Eun-Kee, Baek, Yong-Wook, Lee, Ju-Han   +11 more
openaire   +1 more source

Comprehensive analysis of adverse outcome pathway, potency, human exposure supports carcinogenicity of polyhexamethylene guanidine phosphate in lung cancer

Ecotoxicology and Environmental Safety
In this study, we investigated the potential mechanisms by which polyhexamethylene guanidine phosphate (PHMG-p), a known respiratory irritant, may contribute to lung cancer development.
Yong Joo Park, Ha Ryong Kim, Jun Woo Kim, Jong-Hyun Lee, Younghee Kim, Jungyun Lim, Yong-Wook Baek, Kyu Hyuck Chung   +7 more
doaj   +1 more source