Lipid Mediators in Inflammation [PDF]
, 2016 Lipids are potent signaling molecules that regulate a multitude of cellular responses, including cell growth and death and inflammation/infection, via receptor-mediated pathways. Derived from polyunsaturated fatty acids (PUFAs), such as arachidonic acid (
Bennett, M, Gilroy, DW
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Investigating asparagine-linked glycosylation substrate : specificity and effects on protein folding [PDF]
, 2009 Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2009.Vita.Includes bibliographical references.N-linked glycosylation is a ubiquitous form of protein modification whereby a preassembled oligosaccharide is covalently attached ...
Chen, Mark M
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Small molecule inhibitors of mammalian glycosylation [PDF]
, 2022 Glycans are one of the fundamental biopolymers encountered in living systems. Compared to polynucleotide and polypeptide biosynthesis, polysaccharide biosynthesis is a uniquely combinatorial process to which interdependent enzymes with seemingly broad ...
Almahayni, K. +5 more
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Controlling Glycosyltransferase Activity: Inhibition and Enzyme Engineering [PDF]
, 2021 Glycosyltransferases (GTs) are responsible for the synthesis of a multitude of important glycosylated molecules. These enzymes catalyze the assembly of glycans and glycoconjugates through the transfer of sugar residues from activated donors onto various ...
Ghosh, Trisha +3 more
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Structures of DPAGT1 explain glycosylation disease mechanisms and advance TB antibiotic design [PDF]
, 2018 Summary: Protein N-glycosylation is a widespread post-translational modification. The first committed step in this process is catalysed by dolichyl-phosphate N-acetylglucosamine-phosphotransferase DPAGT1 (GPT/E.C. 2.7.8.15).
Barry III, Clifton E. +31 more
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Physiological Impact of Abnormal Lipoxin A 4 [PDF]
, 2015 Lipoxin A4 has been described as a major signal for the resolution of inflammation and is abnormally produced in the lungs of patients with cystic fibrosis (CF).
Fiona Ringholz +4 more
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Investigation of asparagine-linked glycosylation in archaeal and bacterial systems [PDF]
, 2011 Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, February 2011.Vita. Cataloged from PDF version of thesis.Includes bibliographical references.Asparagine-linked protein glycosylation entails the stepwise assembly of an ...
Larkin, Angelyn (Angelyn Kathryne)
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Structural and Biochemical Characterization of ArnC and ArnD: Key Enzymes in Lipid a Modification With Ara-4N and Polymyxin Resistance [PDF]
, 2023 Antibiotic resistance is an increasing global concern threatening our ability to fight bacterial infections. A key part of the innate immune response is Cationic Antimicrobial Peptides (CAMPs) that constitute an effective defense barrier against ...
Munoz-Escudero, Daniel
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Investigating asparagine-linked protein glycosylation in eukaryotic and prokaryotic systems [PDF]
, 2006 Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2006.Vita.Includes bibliographical references.N-linked protein glycosylation is characterized by the formation of a -glycosylamine linkage to an asparagine residue within the Asn-
Weerapana, Eranthie
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Lipid-Modulated, Graduated Inhibition of N‑Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress [PDF]
Protein N-glycosylation is a cotranslational modification that takes place in the endoplasmic reticulum (ER). Disruption of this process can result in accumulation of misfolded proteins, known as ER stress. In response, the unfolded protein response (UPR)
Carpenter, EP +13 more
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