Results 211 to 220 of about 31,758 (236)
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Manipulation and Analysis of Polyketide Synthases
2004Publisher Summary This chapter examines the manipulation and analysis of polyketide (PKS) synthases. PKS span a large range of medicinally important com-pounds, such as antibiotics, anticancer agents, immunosuppressants, and cholesterol-lowering agents.
Pawan, Kumar, Chaitan, Khosla, Yi, Tang
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Type III Polyketide Synthases in Microorganisms
2012Type III polyketide synthases (PKSs) are simple homodimers of ketosynthases which catalyze the condensation of one to several molecules of extender substrate onto a starter substrate through iterative decarboxylative Claisen condensation reactions. Type III PKSs have been found in bacteria and fungi, as well as plants.
Yohei, Katsuyama, Yasuo, Ohnishi
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Heterologous expression systems for polyketide synthases
Nat. Prod. Rep., 2009Polyketide synthases are the main biochemical machinery for the production of a structurally diverse group of natural products, polyketides. Their heterologous expression enables overproduction of target compounds, generation of novel analogs, and provides a basic understanding of their reaction programs.
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Hybrid Type I and II Polyketide Synthases Yield Distinct Aromatic Polyketides
Journal of the American Chemical SocietyABSTRACTBacterial aromatic polyketides are compounds with multiple aromatic rings synthesized by bacterial type II polyketide synthases (PKSs), some of which have been developed into clinical drugs. Compounds containing aromatic polyketides synthesized by a hybrid type I and type II PKSs are extremely rare.
Li Ya Zhao +8 more
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The erythromycin-producing polyketide synthase
Biochemical Society Transactions, 1993P F, Leadlay +7 more
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Lipogenesis inhibitors: therapeutic opportunities and challenges
Nature Reviews Drug Discovery, 2022Gregory R Steinberg
exaly
Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1
Nature, 2023Min Zhang, Xiaotian Liu, Hongjun Yu
exaly
Genome editing of a rice CDP-DAG synthase confers multipathogen resistance
Nature, 2023Gan Sha, Peng Sun, Xinyu Han
exaly
Molecular mechanisms and consequences of mitochondrial permeability transition
Nature Reviews Molecular Cell Biology, 2021Massimo Bonora +2 more
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Structure, substrate recognition and initiation of hyaluronan synthase
Nature, 2022Jeremi Kuklewicz +2 more
exaly