Results 191 to 200 of about 21,069 (236)
Extended polyene formation by a cryptic iterative polyketide synthase from Rhodococcus.
Chem Commun (Camb)Prasongpholchai P +7 more
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Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase [PDF]
Chemistry and Biology, 2001 Background: Modular polyketide synthases catalyse the biosynthesis of medically useful natural products by stepwise chain assembly, with each module of enzyme activities catalysing a separate cycle of polyketide chain extension.
Peter Leadlay, J Staunton
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High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei [PDF]
FEBS Journal, 2010 Despite the unique phenotypic properties and clinical importance of Penicillium marneffei, the polyketide synthase genes in its genome have never been characterized.
Kwok-Yung Yuen, James J Cai
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Biosynthesis of polyketides by trans-AT polyketide synthases
Natural Product Reports, 2016This review discusses the biosynthesis of natural products that are generated bytrans-AT polyketide synthases, a family of catalytically versatile enzymes that represents one of the major group of proteins involved in the production of bioactive polyketides.
Helfrich Eric J N, Piel Jörn
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Tolerance and Specificity of Polyketide Synthases
Annual Review of Biochemistry, 1999▪ Abstract Polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis. Like fatty acids, polyketides are assembled by successive decarboxylative condensations of simple precursors.
C, Khosla +3 more
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Biosynthesis of polyketides by trans-AT polyketide synthases
Natural Product Reports, 2010This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that have recently been recognized as one of the major group of proteins involved in the production of bioactive polyketides. 436 references are cited.
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Engineering of modular polyketide synthases to produce novel polyketides
Current Opinion in Biotechnology, 1998Polyketides are important natural products produced by Actinomycetes and other organisms via the polymerization of coenzyme A-activated carboxylic acids. Modular polyketide synthases are large multifunctional enzymes that direct the biosynthetic process using a dedicated 'module' for each polymerization reaction, which specifies the unit to be ...
, Carreras, , Santi
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Structures and Mechanisms of Polyketide Synthases
The Journal of Organic Chemistry, 2009Nearly a quarter-century ago, the advent of molecular genetic tools in the field of natural product biosynthesis led to the remarkable revelation that the genes responsible for the biosynthesis, regulation, and self-resistance of complex polyketide antibiotics were clustered in the genomes of the bacteria that produced these compounds.
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Biosynthesis of polyketides by trans-AT polyketide synthases in Burkholderiales
Critical Reviews in Microbiology, 2019Widely used as drugs and agrochemicals, polyketides are a family of bioactive natural products, with diverse structures and functions. Polyketides are produced by megaenzymes termed as polyketide synthases (PKSs). PKS biosynthetic pathways are divided into the cis-AT PKSs and trans-AT PKSs; a division based mainly on the absence of an acyltransferase ...
Hanna, Chen +10 more
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Manipulation and Analysis of Polyketide Synthases
2004Publisher Summary This chapter examines the manipulation and analysis of polyketide (PKS) synthases. PKS span a large range of medicinally important com-pounds, such as antibiotics, anticancer agents, immunosuppressants, and cholesterol-lowering agents.
Pawan, Kumar, Chaitan, Khosla, Yi, Tang
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