Results 181 to 190 of about 186,140 (231)

Strategic Acyl Carrier Protein Engineering Enables Functional Type II Polyketide Synthase Reconstitution In Vitro. [PDF]

ACS Chem Biol
Li K, Cho YI, Tran MA, Wiedemann C, Zhang S, Koweek RS, Hoàng NK, Hamrick GS, Bowen MA, Kokona B, Stallforth P, Beld J, Hellmich UA, Charkoudian LK.   +13 more
europepmc   +1 more source

Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation. [PDF]

ACS Catal
McCullough TM, Choudhary V, Akey DL, Skiba MA, Bernard SM, Kittendorf JD, Schmidt JJ, Sherman DH, Smith JL.   +8 more
europepmc   +1 more source

Extended polyene formation by a cryptic iterative polyketide synthase from Rhodococcus.

Chem Commun (Camb)
Prasongpholchai P, Tucker S, Burgess C, Jenkins R, Wilkening I, Corre C, Song L, Tosin M.   +7 more
europepmc   +1 more source

Aspergillus westerdijkiae polyketide synthase gene “aoks1” is involved in the biosynthesis of ochratoxin A [PDF]

Fungal Genetics and Biology, 2009
OchratoxinA (OTA) is a potential nephrotoxic, teratogenic, immunogenic, hepatotoxic and carcinogenic mycotoxin, produced by Aspergillus westerdijkiae NRRL 3174.
Ahmed Lebrihi, Ali Atoui
exaly   +2 more sources

High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei

FEBS Journal, 2010
Despite the unique phenotypic properties and clinical importance of Penicillium marneffei, the polyketide synthase genes in its genome have never been characterized.
Kwok-Yung Yuen, James J Cai
exaly   +2 more sources

Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase [PDF]

Chemistry and Biology, 2001
Background: Modular polyketide synthases catalyse the biosynthesis of medically useful natural products by stepwise chain assembly, with each module of enzyme activities catalysing a separate cycle of polyketide chain extension.
Peter Leadlay, J Staunton
exaly   +2 more sources

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Biosynthesis of polyketides by trans-AT polyketide synthases

Natural Product Reports, 2016
This review discusses the biosynthesis of natural products that are generated by trans -AT polyketide synthases, a family of catalytically versatile enzymes that represents one of the major group of proteins involved in the production of bioactive polyketides.
Helfrich Eric J N, Piel Jörn
openaire   +3 more sources

Tolerance and Specificity of Polyketide Synthases

Annual Review of Biochemistry, 1999
▪ Abstract  Polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis. Like fatty acids, polyketides are assembled by successive decarboxylative condensations of simple precursors.
C, Khosla, R S, Gokhale, J R, Jacobsen, D E, Cane   +3 more
openaire   +2 more sources

Biosynthesis of polyketides by trans-AT polyketide synthases

Natural Product Reports, 2010
This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that have recently been recognized as one of the major group of proteins involved in the production of bioactive polyketides. 436 references are cited.
openaire   +2 more sources

Structures and Mechanisms of Polyketide Synthases

The Journal of Organic Chemistry, 2009
Nearly a quarter-century ago, the advent of molecular genetic tools in the field of natural product biosynthesis led to the remarkable revelation that the genes responsible for the biosynthesis, regulation, and self-resistance of complex polyketide antibiotics were clustered in the genomes of the bacteria that produced these compounds.
openaire   +2 more sources