Results 201 to 210 of about 21,069 (236)

The Chalcone Synthase Superfamily of Type III Polyketide Synthases

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Michael B, Austin, Joseph P, Noel
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Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases

Nature, 1995
Modular polyketide synthases (PKSs) are complex multi-enzyme proteins that catalyse the bacterial biosynthesis of many pharmaceutically useful polyketides. The PKSs are organized into a series of modules, each containing the active catalytic sites required for one step in the synthesis process.
R, Pieper, G, Luo, D E, Cane, C, Khosla
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Production of a novel polyketide through the construction of a hybrid polyketide synthase

Gene, 1996
The lactone rings of the polyketides platenolide and tylactone are synthesized by condensation of acetate-, proprionate-, and butyrate-derived precursors. A hybrid tylactone/platenolide synthase was constructed to determine if the choice of substrate is programmed by the polyketide synthase and to ascertain if a substrate different than that normally ...
S, Kuhstoss, M, Huber, J R, Turner, J W, Paschal, R N, Rao   +4 more
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Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway [PDF]

FEBS Letters, 2009
Alkylresorcinol moieties of cannabinoids are derived from olivetolic acid (OLA), a polyketide metabolite. However, the polyketide synthase (PKS) responsible for OLA biosynthesis has not been identified.
Tanaka, Shinji, Fukamizu, Tomohide, Tanaka, Hiroyuki, Taguchi, Chiho, Shoyama, Yukihiro, Morimoto, Satoshi, Taura, Futoshi   +6 more
exaly   +2 more sources

Fungal type III polyketide synthases

Nat. Prod. Rep., 2014
This article covers the literature on fungal type III polyketide synthases (PKSs) published from 2005 to 2014. Since the first discovery of fungal type III PKS genes in Aspergillus oryzae, reported in 2005, putative genes for type III PKSs have been discovered in fungal genomes.
Makoto, Hashimoto, Takamasa, Nonaka, Isao, Fujii   +2 more
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Polyketide Synthases: Mechanisms and Models

2006
The modular structure of the multienzyme PKSs makes them particularly attractive targets for combinatorial biosynthesis aimed at generating novel polyketide medicines. We are beginning to understand those features of subunit organization and structure and their linking and docking elements, which are critical for productive engineering efforts ...
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Non-modular polyketide synthases in myxobacteria

Phytochemistry, 2009
Myxobacteria are prolific producers of a wide variety of secondary metabolites. The vast majority of these compounds are complex polyketides which are biosynthesised by multimodular polyketide synthases (PKSs). In contrast, few myxobacterial metabolites isolated to date are derived from non-modular PKSs, in particular type III PKSs. This review reports
Yanyan, Li, Rolf, Müller
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Building-block selectivity of polyketide synthases

Current Opinion in Chemical Biology, 2003
For the past decade, polyketide synthases have presented an exciting paradigm for the controlled manipulation of complex natural product structure. These multifunctional enzymes catalyze the biosynthesis of polyketide natural products by stepwise condensation and modification of metabolically derived building blocks.
Grace F, Liou, Chaitan, Khosla
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Biphenyl synthase, a novel type III polyketide synthase

Planta, 2006
Biphenyls and dibenzofurans are the phytoalexins of the Maloideae, a subfamily of the economically important Rosaceae. The carbon skeleton of the two classes of antimicrobial secondary metabolites is formed by biphenyl synthase (BIS). A cDNA encoding this key enzyme was cloned from yeast-extract-treated cell cultures of Sorbus aucuparia. BIS is a novel
B, Liu, T, Raeth, T, Beuerle, L, Beerhues   +3 more
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Novel applications of plant polyketide synthases

Current Opinion in Chemical Biology, 2012
The structurally and mechanistically simple type III polyketide synthases (PKSs) catalyze iterative condensations of CoA thioesters to produce a variety of polyketide scaffolds with remarkably diverse structures and biological activities. By exploiting the enzymes, we combined precursor-directed biosynthesis with nitrogen-containing substrates and ...
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