Results 211 to 220 of about 21,069 (236)
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Uncovering the structures of modular polyketide synthases
Natural Product Reports, 2015This review covers a breakthrough in the structural biology of the gigantic modular polyketide synthases (PKS): the structural characterization of intact modules by single-particle cryo-electron microscopy and small-angle X-ray scattering.
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Type III Polyketide Synthases in Microorganisms
2012Type III polyketide synthases (PKSs) are simple homodimers of ketosynthases which catalyze the condensation of one to several molecules of extender substrate onto a starter substrate through iterative decarboxylative Claisen condensation reactions. Type III PKSs have been found in bacteria and fungi, as well as plants.
Yohei, Katsuyama, Yasuo, Ohnishi
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Heterologous expression systems for polyketide synthases
Nat. Prod. Rep., 2009Polyketide synthases are the main biochemical machinery for the production of a structurally diverse group of natural products, polyketides. Their heterologous expression enables overproduction of target compounds, generation of novel analogs, and provides a basic understanding of their reaction programs.
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The structures of type I polyketide synthases
Natural Product Reports, 2012With the recent structural characterization of each of the component enzymes of type I polyketide synthases, scientists are coming tantalizingly close to elucidating the overall architectures and mechanisms of these enormous molecular factories. This review highlights not only what has been revealed about the structures and activities of each of the ...
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ChemInform Abstract: Biosynthesis of Polyketides by trans‐AT Polyketide Synthases
ChemInform, 2010AbstractReview: 436 refs.
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The erythromycin-producing polyketide synthase
Biochemical Society Transactions, 1993P F, Leadlay +7 more
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Biosynthesis of 6‐Hydroxymellein Requires a Collaborating Polyketide Synthase‐like Enzyme
Angewandte Chemie - International Edition, 2021Russell Cox +2 more
exaly
[Polyketide antibiotics produced by polyketide synthase in streptomyces--a review].
Wei sheng wu xue bao = Acta microbiologica Sinica, 2010Polyketides have played an important role in antibiotic drug discovery with most antibacterial drugs being derived from a natural product or natural product lead. Furthermore, the biosynthetic gene clusters for numerous bioactive polyketides have been intensively studied over the past 15 years.
Minjie, Chen +4 more
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